meso-DNAs with Homopurine Sequences : Analysis of Their Interaction with Natural DNAs
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概要
- 論文の詳細を見る
Two homopurine sequences of meso-DNAs (DNAs having an alternating sequence of 2-deoxy-L-ribose and 2-deoxy-D-ribose in their suger moieties), d(LADG)_5 and d(LGDA)_5,were prepared. Both d(LADG)_5 and d(LGDA)_5 interacted with the corresponding complementary natural DNAs, d(DCDT)_5 and d(DTDC)_5,respectively. In the interactions, pH-dependent duplex/triplex selectivity was observed, i.e., meso-d(Pu)_<10> formed a duplex at pH 7.5 and a triplex at pH 5.0 with the complementary D-d(Py)_<10>. The meso-d(Pu)_<10>/D-d(Py)<10> complex showed a CD spectrum similar in shape to that of the natural complex, suggesting that meso/natural complexes form right-handed helices. At pH 7.5,ethidium bromide intercalated into both d(LADG)_5/d(DCDT)_5 and d(LGDA)_5/d(DTDC)_5 duplexes. A clear difference between d(LADG)_5/d(DCDT)_5 and d(LGDA)_5/d(DTDC)_5 was observed at pH 5.0. Addition of ethidium bromide did not affect the formed d(LADG)_5/d(DCDT)_5 triplex, and ethidium bromide did not interacalate into the triplex. On the other hand, d(LGDA)_5 did not form a triplex with d(DTDC)_5 in the presence of ethidium bromide even at pH 5.0,but it formed a duplex. Ethidium bromide intercalated into the duplex at pH 5.0.
- 公益社団法人日本薬学会の論文
- 1996-05-15
著者
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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SHUDO Koichi
Faculty of Pharmaceutical Sciences, The University of Tokyo
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Shudo Koichi
Faculty Of Pharmaceutical Science Kyushu University
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IWANAMI Naoko
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Iwanami Naoko
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Shudo Koichi
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Hashimoto Yuichi
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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