Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton
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概要
- 論文の詳細を見る
Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/platelet-derived endothelial cell growth factor(TP/PD-ECGF)was assessed. Among them, 2-(2, 6-diethylphenyl)-7-nitro-1, 2, 3, 4-tetrahydroisoquinoline-1, 3-dione(9)was found to be a more potent inhibitor than the classical inhibitor, 5-nitrouracil(1). Lineweaver-Burk plot analysis indicated that 9 shows mixed-type competitive inhibition of TP/PD-ECGF, while 1 is a competitive inhibitor.
- 公益社団法人日本薬学会の論文
- 2001-07-01
著者
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Hashimoto Yuichi
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Kita Tetsuya
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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TAKAHASHI Hiroyasu
Institute of Molecular and Cellular Biosciences, University of Tokyo
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Takahashi Hiroyasu
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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