Potent Homophthalimide-Type Inhibitors of B16F10/L5 Mouse Melanoma Cell Invasion
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概要
- 論文の詳細を見る
Recently, we developed a series of novel and potent aminopeptidase inhibitors with a homophthalimide skeleton. Among them, N-(2,6-diethylphenyl)homophthalimide (PIQ-22) possesses a specific aminopeptidase-inhibiting activity more potent than that of bestatin or actinonin, as assayed in terms of hydrolysis of L-alanine 4-methylcoumaryl-7-amide (Ala-AMC) by human acute lymphoblastic leukemia MOLT-4 cells. We show here that PIQ-22 and its 2,6-dimethylphenyl derivative (PIQ-11) are more potent inhibitors of tumor cell invasion than bestatin and actinonin in a Matrigel assay using mouse melanoma B16F10/L5 cells.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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藤本 康弘
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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小磯 邦子
東大分生研
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Takayama Hiroaki
帝京大学 薬
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KAGECHIKA Hiroyuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Kagechika Hiroyuki
Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Hashimoto Y
Univ. Tokyo Tokyo Jpn
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KOISO Yukiko
Institute of Molecular and Cellular Biosciences, University of Tokyo
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Hashimoto Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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KOMODA Masato
Institute of Molecular and Cellular Biosciences University of Tokyo
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FUJIMOTO Yasuyuki
Institute of Molecular and Cellular Biosciences University of Tokyo
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TAKAYAMA Hisae
Institute of Molecular and Cellular Biosciences University of Tokyo
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KADOYA Shizuo
Institute of Molecular and Cellular Biosciences University of Tokyo
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MIYATA Keizo
Institute of Molecular and Cellular Biosciences University of Tokyo
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KATO Fuminori
R&D Group for Pharmaceuticals, Central Research Institute, Ishihara Sangyo Kaisha Ltd.,
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KATO Masanari
R&D Group for Pharmaceuticals, Central Research Institute, Ishihara Sangyo Kaisha Ltd.,
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Hashimoto Yuichi
Institute Of Molecular & Cellular Biosciences University Of Tokyo
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Komoda M
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Kadoya S
Research Institute Of Daiichi Seiyaku Co. Ltd.
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Kato F
R&d Group For Pharmaceuticals Central Research Institute Ishihara Sangyo Kaisha Ltd.
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Kato Masanari
R&d Group For Pharmaceuticals Central Research Institute Ishihara Sangyo Kaisha Ltd.
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Fujimoto Y
Department Of Biochemistry Hokkaido College Of Pharmacy
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