4 Kopsia offcinalisより単離された新規インドールアルカロイドKopsiyunnanines A-Dの構造決定(口頭発表の部)

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Plants of the Kopsia genus (Apocynaceae) ranging from evergreen trees to shrubs are well known as fertile sources of structurally diversified indole alkaloids. There are 23 species belonging to this genus, which has a widespread distribution from southern China and Burma to northern Australia and Vanuatu and is most diverse in Peninsular Malaysia and Borneo. Among them, Kopsia officinalis Tsiang et P.T. Li (this species was amended to Kopsia arborea in the view of Dr. Middleton's latest revision) indigenous to Yunnan province in southwest of China has been reported for medicinal uses for the treatment of rheumatoid arthritis, dropsy, and tonsillitis. As a part of our ongoing program to search for novel and bioactive indole alkaloids, phytochemical research on this plant has led to the isolation of more than 40 alkaloids. Of these, several, such as arboloscine (10) and mersicarpine (11) are interesting for incorporating intriguing molecular skeletons. In this symposium, we present the structure elucidation of six unusual indole alkaloids, i.e.: the novel dimeric indole alkaloid kopsiyunnanine A (1), the novel rearranged oxindole alkaloid kopsiyunnanine B (2), three novel rhazinilam analogues kopsiyunnanine Cl (4), kopsiyunnanine C2 (5) and kopsiyunnanine C3 (6), and an unusual quebrachamine derivative kopsiyunnanine D (8) (Figure 1). In addition, one another novel alkaloid, named kopsiyunnanine E (9), which possesses a particular notable pentacyclic carbon skeleton incorporating a lactone ring, will be also introduced.
2008-09-01

4 Kopsia offcinalisより単離された新規インドールアルカロイドKopsiyunnanines A-Dの構造決定(口頭発表の部)

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