The First Synthesis of 24,24-Difluoro-1α-hydroxyvitamin D_3 by Means of Radical Deoxygenation of Alcohols
スポンサーリンク
概要
- 論文の詳細を見る
The first synthesis of the title compound 4,a novel analog of 1α-hydroxyvitamin D (α-calcidiol) that might be therapeutically useful, is described. A key feature in the synthesis is the radical deoxygenation of the diol 21,which was prepared according to the previously reported procedure starting from 17. The resulting deoxygenated product 22 with the desired side-chain moiety was finally led to 4 in a conventional manner. Some aspects of the unusual reactivity of 25-OH on radical deoxygenation are also discussed.
- 社団法人日本薬学会の論文
- 1996-01-15
著者
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Takayama H
Faculty Of Pharmaceutical Sciences Teikyo University
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Takayama Hiroaki
Faculty Of Pharmaceutical Sciences Teikyo University
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Maki S
(present Address)department Of Applied Physics And Chemistry The University Of Electro-communication
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Kondo F
Faculty Of Pharmaceutical Sciences Teikyo University
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KONNO Katsuhiro
Faculty of Pharmaceutical Sciences, Teikyo University
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KONDO Fumihiro
Faculty of Pharmaceutical Sciences, Teikyo University
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MAKI Shojiro
Faculty of Pharmaceutical Sciences, Teikyo University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Kondo Fumihiro
Faculty Of Pharmaceutical Sciences Teikyo University
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Konno K
Teikyo Univ. Kanagawa Jpn
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Konno Katsuhiro
Faculty Of Pharmaceutical Sciences Teikyo University
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