First Total Synthesis of a Novel Monoterpenoid Isoquinoline Alkaloid, (±)-Alangine(Communications to the Editor)
スポンサーリンク
概要
- 論文の詳細を見る
The structure including the stereochemistry of a novel monoterpenoid isoquinoline alkaloid, alangine, was confirmed by total synthesis via N-acyliminium cyclization to construct the isoquinoline skeleton and reductive cleavage of vinyl epoxide with Pd(0) catalyst.
- 社団法人日本薬学会の論文
- 2002-08-01
著者
-
Takayama Hiroaki
帝京大学 薬
-
高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
-
KITAJIMA Mariko
Graduate School of Pharmaceutical Sciences, Chiba University
-
TAKAYAMA Hiromitsu
Graduate School of Pharmaceutical Sciences, Chiba University
-
AIMI Norio
Graduate School of Pharmaceutical Sciences, Chiba University
-
ARAI Maki
Graduate School of Pharmaceutical Sciences, Chiba University
-
Kitajima Mariko
Graduate School Of Pharmaceutical Sciences Chiba University
-
Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
-
Takayama Hiromitsu
Graduate School Of Pharmaceutical Sciences Chiba University
-
Arai Maki
Graduate School Of Pharmaceutical Sciences Chiba University
-
Aimi N
Graduate School Of Pharmaceutical Sciences Chiba University
-
Aimi Norio
Graduate School Of Pharmaceutical Sciences Chiba University
-
Kitajima M
Department Of Biofunctional Molecular Chemistry Graduate School Of Pharmaceutical Sciences Chiba Uni
関連論文
- 麻薬性タイ国伝承民間薬 Mitragyna speciosa からのオピオイド活性成分の発見とその構造活性相関
- 68(P-51) タイ、マレーシア伝承薬物Mitragyna speciosa含有鎮痛性インドールアルカロイドに関する医薬化学的研究(ポスター発表の部)
- P-37 釣藤鈎アルカロイド Hirsutine および Dihydrocorinantheine の心筋活動電位に対する作用
- 29D-01 タイ薬用植物成分 Mitragynine を基礎としてデザインした 9-hydroxy corynantheidine の opioid 受容体における partial agonist 特性
- 13 マレーシア産Mitragyna speciosaに含有される鎮痛性インドールアルカロイドの化学的・薬理学的研究(口頭発表の部)
- 30C-16 釣藤鈎アルカロイド Hirsutine のオピオイド受容体拮抗作用
- II-A-2 モルヒネ代用タイ民間薬成分 mitragynine の鎮痛作用および平滑筋収縮関連の Ca^ チャネル遮断作用の解析
- P-13 タイ国薬用植物 Mitragyna speciosa 含有の鎮痛性インドールアルカロイド mitragynine の平滑筋収縮抑制作用の解析
- 48(P-15) ヒカゲノカズラ科植物Lycopodium serratum含有アルカロイド類に関する化学的研究(ポスター発表の部)
- I-074(30) 釣藤鈎アルカロイド成分リンコフィリン及びイソリンコフィリンの in vitro 海馬虚血モデルにおける神経保護作用とその機序
- 88(P-24) タイ産アカネ科植物Uncaria attenuata含有新規オキシインドールアルカロイド類の合成研究(ポスター発表の部)
- P-4 冶葛含有アルカロイドの薬理活性(第 3 報) : 心血管系作用に関する検討
- P-3 冶葛含有アルカロイドの薬理活性(第 1 報) : 毒性発現機序と抗腫瘍活性に関する検討
- 74(P-31) Una de Gato含有新規アルカロイド並びにトリテルペン類の化学的研究(ポスター発表の部)
- P-35 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- MS-I-3 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- 97(P-10) Pandanus属植物含有新規ピロリジン型アルカロイドの構造決定とバイオミメティック全合成(ポスター発表の部)
- 伝承的アヘン代用薬(Mitragyna speciosa)由来の鎮痛性インドールアルカロイドに関する化学的研究
- P-38 アカネ科植物由来伝承薬の含有インドールアルカロイドに関する化学的研究 : Uncaria 属と Mitragyna 属を中心に
- カンプトテシン系アルカロイドの化学
- 48(P05) アカネ科チャボイナモリの細胞培養によるカンプトテシン類の生産とその関連化合物の合成研究(ポスター発表の部)
- P-23 タイ薬用植物Mitragyna speciosaに含有されるインドールアルカロイド類の構造と化学合成及び薬理学的研究(ポスター発表の部)
- New Corymine-Related Indole Alkaloids from Hunteria zeylanica in Thailand
- P-21 南タイ産キョウチクトウ科植物より得られる新規インドールアルカロイド類の構造研究(ポスター発表の部)
- A NEW CLASS OF TWO DIMERIC INDOLE ALKALOIDS, CORYZEYLAMINE AND DEFORMYLCORYZEYLAMINE, FROM THE LEAVES OF HUNTERIA ZEYLANICA IN THAILAND
- Novel Indole Alkaloids from the Leaves of Rauwolfia sumatrana JACK. in Thailand
- HUNTERIOSIDE, FIRST BIOSE BOUND MONOTERPENOID INDOLE ALKALOID FROM HUNTERIA ZEYLANICA
- Two New Dimeric Indole Alkaloids from Tabernaemontana subglobosa MERR. from Taiwan
- A Nuclear Magnetic Resonance Study on the Eleven Stereoisomers of Heteroyohimbine-Type Oxindole Alkaloids
- 7 生合成考察に基づくフマンテニン型及びゲルセジン型ゲルセミウム属アルカロイド類の化学合成(口頭発表の部)
- The Structure of Garcinone E
- On the Alkaloidal Constituents of Aconitum sanyoense NAKAI var. tonense NAKAI
- 4 Kopsia offcinalisより単離された新規インドールアルカロイドKopsiyunnanines A-Dの構造決定(口頭発表の部)
- 19 新規三量体型インドールアルカロイドpsychotrimineの全合成(口頭発表の部)
- P-32 多量体型pyrrolidinoindolineアルカロイドの探索と合成研究(ポスター発表の部)
- Kopsiyunnanines F and isocondylocarpines : new tubotaiwine-type alkaloids from Yunnan Kopsia arborea
- Flavonols from Bauhinia malabarica
- New Iridoids from Gelsemium Species
- Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis
- Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens
- New heteroyohimbine-type oxindole alkaloid from the leaves of Thai Mitragyna hirsuta
- P-27 ゲルセミウム属植物含有新規インドールアルカロイドの探索と腫瘍細胞殺傷作用(ポスター発表の部)
- Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)
- P-258 GELSEIRIDONE AND GELSEFURANIDINE, NEW TYPE OF MONOTERPENOID INDOLE ALKALOIDS ISOLATED FROM Gelsemium elegans Benth
- 味認識装置による漢方処方の味の評価に関する研究(第2報)葛根湯に関する検討
- Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai
- New Oleanan-Type Triterpene and Cincholic Acid Glycosides from Peruvian "Una de Gato" (Uncaria tomentosa)
- A New 9-Methoxyyohimbine-Type Indole Alkaloid from Mitragyna africanus
- 釣藤散,釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として
- Novel Oxidaiton of Vitamin D_2 by an Electrochemical Method
- m-Chloroperbenzoic Acid Oxidation of Corynanthe-Type Indole Alkaloid, Mitragynine, Afforded Unusual Dimerization Products
- New Oxindole Alkaloids and Iridoid from Carolina jasmine (Gelsemium sempervirens AIT. f.)
- Ten New Lycopodium Alkaloids Having the Lycopodane Skeleton Isolated from Lycopodium serratum THUNB.
- Gluco-indole Alkaloids from Nauclea cadamba in Thailand and Transformation of 3α-Dihydrocadambine into the Indolopyridine Alkaloid, 16-Carbomethoxynaufoline (Communications to the Editor)
- Uncaria属オキシインドール類の構造と化学--DFTの応用を中心として (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 天然資源と医薬品開発3)
- Camptothecin-related Alkaloids from Culture Medium of Hairy Roots of Ophiorrhiza pumila
- Collision-Induced Dissociation Actualized the H^+-Promoted Reaction as Observed in Vitro ; Harman Formation from β-Carboline-Type Monoterpenoid Glucoindole Alkaloids
- 未利用薬用資源植物から創薬シード分子を探す
- Synthesis and Absolute Configuration of a New 3, 4-Dihydro-β-carboline-Type Alkaloid, 3, 4-Dehydro-5(S)-5-carboxystrictosidine, Isolated from Peruvian Una de Gato (Uncaria tomentosa)
- Isolation and Structure Elucidation of Two New Alkaloids, Pandamarilactonine-C and -D, from Pandanus amaryllifolius and Revision of Relative Stereochemistry of Pandamarilactonine-A and -B by Total Synthesis(Communications to the Editor)
- First Total Synthesis of a Novel Monoterpenoid Isoquinoline Alkaloid, (±)-Alangine(Communications to the Editor)
- Formation of an Unusual Dimeric Compound by Lead Tetraacetate Oxidation of a Corynanthe-Type Indole Alkaloid, Mitragynine
- 生合成経路を模擬したアルカロイド合成 : 最近の話題から
- Co-occurrence of Harman and β-Carboline-type Monoterpenoid Glucoindole Alkaloids in Una de Gato (Uncaria tomentosa)
- A New Type of Stilbene-Related Secondary Metabolite, Idenburgene, from Cryptocarya idenburgensis
- A New Gluco Indole Alkaloid, 3,4-Dehydro-5-carboxystrictosidine, from Preruvian Una de Gato (Uncaria tomentosa)
- Triterpenoids from Thai Medicinal Plant, Willughbeia firma
- First Synthesis of Neoalangiside, a New Tetrahydroisoquinoline-monoterpene Glucoside with Oxygen Functions at Unusual C1,C2 Positions
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- タイ薬用植物成分 mitragynine の抗侵害受容作用に関与するオピオイド受容体サブタイプ
- DEEPER INSIGHTS INTO THE STEREOSTRUCTURE OF STRICTOSAMIDE TETRAACETATE AND METHYLISOALANGISIDE TETRAACETATE, THE KEY REFERENCE MOLECULES IN MONOTERPENOID INDOLE- AND ISOQUINOLINE GLUCOALKALOIDS
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- A Novel Reaction of Cyanate with Dehydroascorbate
- STRUCTURE AND SYNTHESIS OF A NEW CHIRAL β-CARBOLINE FOUND IN CULTURED CELL CLUMPS OF RAUWOLFIA SERPENTINA AND RHAZYA STRICTA
- BIOMIMETIC SYNTHESIS OF NAUCLEA INDOLE ALKALOIDS, NAUCLEIDINAL, AND 3-EPI-NAUCLEIDINAL, BY STEREOSELECTIVE REARRANGEMENT OF STRICTOSAMIDE AND THE VINCOSIDE LACTAM AGLYCONES
- ISOLATION OF ALKALOIDS FROM CULTURED HYBRID CELLS OF RAUWOLFIA SERPENTINA x RHAZYA STRICTA
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
- Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on Acute Inflammation in Experimental Animals
- Biological Activities of 2α-Substituted Analogues of 1α, 25-Dihydroxyvitamin D_3 in Transcriptional Regulation and Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation(Medicinal Chemistry)
- 生物活性リコポジウムアルカロイドの探索と不斉合成
- Potent Homophthalimide-Type Inhibitors of B16F10/L5 Mouse Melanoma Cell Invasion
- 2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropoxy)-1α, 25-dihydroxyvitamin D_3 Accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets
- ものとり屋の全合成
- Chemical studies on monoterpenoid indole alkaloids from medicinal plant resources Gelsemium and Ophiorrhiza
- A new prenylated dihydrochalcone from the leaves of Artocarpus lowii
- Two New Aspidosperma Indole Alkaloids from Yunnan Kopsia arborea
- The botanical origin of kratom (Mitragyna speciosa ; Rubiaceae) available as abused drugs in the Japanese markets
- Message from the chief editor
- Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
- P-234 FIRST TOTAL SYNTHESIS OF (-)-SUBINCANADINE A AND ent-SUBINCANADINE B, NOVEL PENTACYCLIC INDOLE ALKALOIDS, FOUND IN ASPIDOSPERMA SUBINCANUM
- Analytical method of heparan sulfates using high-performance liquid chromatography turbo-ionspray ionization tandem mass spectrometry
- Co-occurrence of Harman and β-Carboline-type Monoterpenoid Glucoindole Alkaloids in Una de Gato (Uncaria tomentosa)
- Triterpenoids from Thai Medicinal Plant, Willughbeia firma
- Isolation of Lignans and Ionone-Type Sesquiterpenes from Leaves of Okinawan Pandanus Tectorius.(Natural Medicine Note)
- Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius
- Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum
- Camptothecin-related Alkaloids from Culture Medium of Hairy Roots of Ophiorrhiza pumila(Natural Medicine Note)