Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai
スポンサーリンク
概要
- 論文の詳細を見る
Camptothecin-derived compounds are widely used for clinical treatment of human cancer. They are synthesized from natural camptothecin, which is obtained by extraction from intact plants. For the feasible production of camptothecin, tissue cultures of Ophiorrhiza liukiuensis and O. kuroiwai, an interspecies hybrid of O. liukiuensis and O. pumila, have been investigated. The aseptic plants and hairy roots of O. liukiuensis and O. kuroiwai were established in addition to the previously-established O. pumila. The camptothecin production by O. kuroiwai was better than that by O. liukiuensis. 10-Methoxycamptothecin was accumulated in tissue cultures of O. liukiuensis and O. kuroiwai but not in O. pumila. Methyl jasmonic acid slightly enhanced the production of camptothecin in the O. liukiuensis hairy roots. These results indicate that the tissue cultures of O. liukiuensis and O. kuroiwai would be the feasible ways for production of camptothecin and related alkaloids.
- 日本植物細胞分子生物学会の論文
- 2004-12-01
著者
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Takayama H
Faculty Of Pharmaceutical Sciences Teikyo University
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Takayama Hiroaki
帝京大学 薬
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Takayama Hiroaki
Faculty Of Pharmaceutical Sciences Teikyo University
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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KITAJIMA Mariko
Graduate School of Pharmaceutical Sciences, Chiba University
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TAKAYAMA Hiromitsu
Graduate School of Pharmaceutical Sciences, Chiba University
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AIMI Norio
Graduate School of Pharmaceutical Sciences, Chiba University
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SUDO Hiroshi
Graduate School of Pharmaceutical Sciences, Chiba University
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SAITO Kazuki
Graduate School of Pharmaceutical Sciences, Chiba University
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ASANO Takashi
Graduate School of Pharmaceutical Sciences, Chiba University
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WATASE Ikumi
Graduate School of Pharmaceutical Sciences, Chiba University
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YAMAZAKI Mami
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamazaki Mami
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Yamazaki Mami
Graduate School Of Pharmaceutical Sciences Chiba University
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Asano Takashi
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Kitajima Mariko
Graduate School Of Pharmaceutical Sciences Chiba University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Takayama Hiromitsu
Graduate School Of Pharmaceutical Sciences Chiba University
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Sudo Hiroshi
Graduate School Of Pharmaceutical Sciences Chiba University
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Aimi N
Graduate School Of Pharmaceutical Sciences Chiba University
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Aimi Norio
Graduate School Of Pharmaceutical Sciences Chiba University
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Saito Kazuki
Graduate School Of Pharmaceutical Sciences Chiba University
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Watase Ikumi
Graduate School Of Pharmaceutical Sciences Chiba University
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Yokoya M
Chiba Univ. Chiba Jpn
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Saito Kazuki
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Sudo H
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Kitayama Masahiko
Institute Of Life Science Ehime Women's College
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Yamazaki Mami
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Saito Kazuki
Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U
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Kabashima Misako
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
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Kitajima M
Department Of Biofunctional Molecular Chemistry Graduate School Of Pharmaceutical Sciences Chiba Uni
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