2α-(3-Hydroxypropyl)- and 2α-(3-Hydroxypropoxy)-1α, 25-dihydroxyvitamin D_3 Accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets
スポンサーリンク
概要
- 論文の詳細を見る
Hereditary vitamin D-resistant riekets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor, which lead to resistance to 1α, 25-dihydroxyvitamin D_3 [1α,25(OH)_2D_3]. We found that the A ring-modified analogues, 2α-(3-hydroxy-propyl)- and 2α-(3-hydroxypropoxy)-1α, 25(OH)_2D_3, (O1C3 and O2C3) can hind better than the natural hormone to the mutant VDR (R274A), which similar to the HVDRR mutant, R274L, had lost the hydrogen bond to the 1α-hydroxyl group ofα, 25(OH)_2D_3.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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Takayama H
Faculty Of Pharmaceutical Sciences Teikyo University
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Takayama Hiroaki
帝京大学 薬
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Takayama Hiroaki
Faculty Of Pharmaceutical Sciences Teikyo University
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SUHARA Yoshitomo
Department of Hygienic Sciences, Kobe Pharmaceutical University
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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KITTAKA Atsushi
Faculty of Pharmaceutical Sciences, Teikyo University
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KURIHARA Masaaki
Faculty of Pharmaceutical Sciences, Teikyo University; National Institute of HealthSciences; M. D. A
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PELEG Sara
Faculty of Pharmaceutical Sciences, Teikyo University; National Institute of HealthSciences; M. D. A
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SUHARA Yoshitomo
Faculty of Pharmaceutical Sciences, Teikyo University; National Institute of HealthSciences; M. D. A
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Suhara Yoshitomo
Department Of Hygienic Sciences Kobe Pharmaceutical University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Peleg Sara
Faculty Of Pharmaceutical Sciences Teikyo University; National Institute Of Healthsciences; M. D. An
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Suhara Y
Department Of Hygienic Sciences Kobe Pharmaceutical University
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Kittaka Atsushi
Faculty Of Pharmaceutical Sciences Teikyo University
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橘高 敦史
帝京大学薬学部薬化学教室
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Kurihara Masaaki
Faculty Of Pharmaceutical Sciences Teikyo University; National Institute Of Healthsciences; M. D. Anderson Cancer Center The University Of Texas; Faculty Of Pharmaceutical Sciences Teikyo University
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