Synthesis and Biological Activity of a 1α, 25-Dihydroxyvitamin D_2 Analog Bearing an Amide Group in the Side-Chain
スポンサーリンク
概要
- 論文の詳細を見る
Synthesis of a 1α, 25-dihydroxyvitamin D_2 analog (3), in which the double bond in the side-chain in replaced by an amide group, is described. Condensation of a carboxylic acid (8) with an amine (6) gave an amide (9), which in turn led to 3 via several steps. The analog (3) could not bind to the chick cytosol vitamin D receptor, which indicated the importance of the hydrophobic interaction of the C(22)-C(23) double bond in 1α, 25-dihydroxyvitamin D_2 (2) with the vitamin D receptor.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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Takayama Hiroaki
Faculty Of Pharmaceutical Sciences Teikyo University
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Konno K
Teikyo Univ. Kanagawa Jpn
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Konno Katsuhiro
Faculty Of Pharmaceutical Sciences Teikyo University
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Hayashi Takaaki
Faculty Of Pharmaceutical Sciences Teikyo University
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Hayashi Takaaki
Faculty Of Integrated Arts And Sciences University Of Tokushima
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OJIMA Katsuji
Faculty of Pharmaceutical Sciences, Teikyo University
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TANABE Miyuki
Research Laboratories, Asahi Chemical Industry Corporated
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Ojima K
Faculty Of Pharmaceutical Sciences Teikyo University
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Tanabe Miyuki
Research Laboratories Asahi Chemical Industry Corporated
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