Interaction of Arenastatin A with Porcine Brain Tubulin
スポンサーリンク
概要
- 論文の詳細を見る
Arenastatin A, isolated from the Okinawan marine sponge Dysidea arenaria, is an antimitotic depsipeptide containing a 16-membered ring. Interaction of the compound with tubulin was investigated by the use of [^3H]arenastatin A and other microtubule disruptors. Scatchard analysis indicated the presence of one binding site for arenastatin A per tubulin heterodimer with a dissociation constant (K_d) of 1.8×10^<-6> M. Rhizoxin was a competitive inhibitor of arenastatin A binding, and vinblastine also inhibited arenastatin A binding in a partially competitive manner. Arenastatin A had no inhibitory effect on colchicine binding to tubulin.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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小磯 邦子
東大分生研
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Hashimoto Yuichi
Univ. Tokyo Tokyo Jpn
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IWASAKI Shigeo
Institute of Molecular and Cellular Biosciences, The University of Tokyo
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KOBAYASHI Motomasa
Faculty of Pharmaceutical Sciences, Osaka University
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KOISO Yukiko
Institute of Molecular and Cellular Biosciences, University of Tokyo
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WANG Weiqi
Faculty of Pharmaceutical Sciences, Osaka University
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MORITA Koji
Institute of Environmental Systems, Faculty of Engineering, Kyushu University
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Kobayashi Motomasa
Faculty Of Pharmaceutical Sciences
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Iwasaki S
Institute Of Molecular And Cellular Biosciences The University Of Tokyo
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Wang Weiqi
Faculty Of Pharmaceutical Sciences Osaka University
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OHYABU Naoki
Faculty of Pharmaceutical Sciences, Osaka University
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Ohyabu N
Faculty Of Pharmaceutical Sciences Osaka University
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Ohyabu Naoki
Faculty Of Pharmaceutical Sciences Osaka University
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Iwasaki S
Univ. Tokyo Tokyo
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Morita Koji
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Morita Koji
Institute Of Environmental Systems Faculty Of Engineering Kyushu University
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Iwasaki Shigeo
Institute Of Molecular And Cellular Biosciences (imcb) The University Of Tokyo
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IWASAKI Shigeo
Institute of Molecular and Cellular Bioscience, The University of Tokyo
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