Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.

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概要

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• Aragusteroketals A (1) and C (2), two new marine steroids having dimethylketal structure, were isolated from an Okinawan marine sponge of Xestospongia sp. The chemical structures of 1 and 2 were determined on the basis of spectroscopic analysis and chemical evidence. Compounds 1 and 2 showed potent cytotoxic activity with the same IC_<50> value of 4 ng/ml against KB cells.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• Akiyama Shin-ichi

  大阪大学 薬研究

• 北川 勲

  大阪大学

• Akiyama Shin-ichi

  The Institute Of Chemotherapy Kagoshima University Faculty Of Medicine

• Aoki S

  Graduate School Of Pharmaceutical Sciences Osaka University

• KOBAYASHI Motomasa

  Faculty of Pharmaceutical Sciences, Osaka University

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• AOKI Shunji

  Faculty of Pharmaceutical Sciences, Osaka University

• Aoki Shinji

  Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi Motomasa

  Faculty Of Pharmaceutical Sciences

• Kobayashi Masao

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• HIGUCHI Kouichi

  Graduate School of Pharmaceutical Sciences, Osaka University

• Higuchi K

  Graduate School Of Pharmaceutical Sciences Osaka University

• Chen Yin-ju

  Faculty Of Pharmaceutical Sciences Osaka University

• HIGUCHI Kouichi

  Faculty of Pharmaceutical Sciences, Osaka University

• KITAGAWA Isao

  (Present address)Faculty of Pharmaceutical Sciences, Kinki niversity

• 小林 資正

  Graduate School Of Pharmaceutical Sciences Osaka University

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