IMPROVED TOTAL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF ARENASTATIN A, A POTENT CYTOTOXIC SPONGEAN DEPSIPEPTIDE
スポンサーリンク
概要
- 論文の詳細を見る
An efficient asymmetric synthesis of a cyclic depsipeptide arenastatin A (1) is described. 1,isolated from the marine sponge Dysidea arenaria, exhibited extremely potent cytotoxicity with IC_<50> of 5 pg/ml for KB cells, and in this context the structure-activity relationship among several stereoisomers of 1 and allied compounds has also been examined.
- 公益社団法人日本薬学会の論文
- 1995-09-15
著者
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北川 勲
Faculty of Pharmaceutical Sciences, Osaka University
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小林 資正
Faculty of Pharmaceutical Sciences, Osaka University
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北川 勲
大阪大学
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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黒須 三千夫
阪大薬
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Kobayashi M
Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North
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大藪 巨樹
Faculty Of Pharmaceutical Sciences Osaka University
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王 維奇
阪大院・薬
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王 維奇
Faculty of Pharmaceutical Sciences, Osaka University
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大薮 巨樹
Faculty of Pharmaceutical Sciences, Osaka University
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黒須 三千代
Faculty of Pharmaceutical Sciences, Osaka University
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Kobayashi M
Faculty Of Pharmaceutical Sciences Osaka University
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Kobayashi Masao
Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.
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小林 資正
Graduate School Of Pharmaceutical Sciences Osaka University
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