An Immunohistochemical Analysis of Gastric B-cell Lymphomas : Stromal Cells Exhibit Peculiar Histogenesis in Gastric B-cell Lymphomas
スポンサーリンク
概要
- 論文の詳細を見る
Anti-Hellcobacter pylori (HP) therapy succeeded in regressing gastric B-cell lymphomas (gBL) with a close relation to infestation of HP, although the exact mechanism of anti-HP therapy in gBL has not yet been clarified. In order to see a part of the mechanism, this study analyzed stromal cells in 34 gBL cases comprised of 11 cases of mucosa-associated lymphold tissue (MALT) type and 24 cases of diffuse large B-cell lymphoma (DLBL) by means of immunohistochemistry of CD3, CD5, CD79a, CD68, CD21, S100 protein, thymidine phosphorylase (TP) and inducible nitric oxide synthase (iNOS). Numerous CD68-positive stromal cells were seen in 9 cases of MALT type and 22 cases of DLBL. Many dendritic cells (DC) expressed TP and formed an ill-defined meshwork in the background in 8 cases of MALT type and 17 cases of DLBL. In most cases, transition of CD68-positive stromal cells to DC expressing TP was recognized. There was more or less intermingling of CD3-positive T-cells in all cases. Expression of iNOS was seen in some stromal cells and glandular epithelial cells, but only in 3 cases of MALT type. In the germinal center (GC) colonization of MALT type there were CD21-positive follicular DC, CD68-positive stromal cells, TP-ex pressing DC and iNOS-expressing cells ; whereas in that of DLBL the meshwork of CD21-positive follicular DC was destroyed and the stromal cells did not express TP or iNOS. Then, a peculiar co-existence of intermingling T-cells, CD68-positive stromal cells, DC expressing TP forming an ill-defined meshwork, and lymphoma cells were recognized in gBL. A small number of stromal cells and glandular epithelial cells expressed iNOS and prepared a nitric oxide-rich micro-environment for growth and transformation of MALT type lymphoma cells. This peculiar histogenesis of gBL was thought to explain a part of the mechanism of the anti-HP therapy against gBL.
- 日本組織細胞化学会の論文
- 2003-11-02
著者
-
村田 長芳
鹿児島医療技術専門学校
-
村田 長芳
鹿児島大学 第1外科
-
Hasui Kazuhisa
The Second Department of Anatomy, Kagoshima University Faculty of Medicine
-
Li Fang
Department of Pathology, China Medical University
-
Jia Xin-Shan
Department of Pathology, China Medical University
-
Nakagawa Masanori
Department of Neurology and Gerontology, Research Institute for Neurological Diseases and Geriatrics
-
Nakamura Takao
Kagoshima institute of Preventive Medicine
-
Yonezawa Suguru
The Second Department of Pathology, Kagoshima University Faculty of Medicine
-
Izumo Shuji
Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Kagoshi
-
Akiyama Shin-ichi
The Institute of Chemotherapy, Kagoshima University Faculty of Medicine
-
Sato Eiichi
Kagoshima University
-
Murata Fusayoshi
The Second Department of Anatomy, Kagoshima University Faculty of Medicine
-
Akiyama Shin-ichi
大阪大学 薬研究
-
Jia Xin-shan
鹿児島大学 2解剖
-
Jia Xin-shan
Department Of Pathology China Medical University
-
Nakagawa Masanori
京都府立医科大学 神経内科学
-
Nakagawa Masanori
Third Department Of Internal Medicine Kagoshima University Faculty Of Medicine
-
Akiyama Shin-ichi
The Institute Of Chemotherapy Kagoshima University Faculty Of Medicine
-
Akiyama Shin-ichi
The Institute Of Cancer Research Kagoshima University
-
佐藤 英一
宇宙科学研究所
-
Aoki S
Graduate School Of Pharmaceutical Sciences Osaka University
-
Izumo S
Division Of Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Diseases Kagoshima
-
Izumo Shuji
Division Of Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Diseases Kagoshima
-
Izumo Shuji
Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Disease Kagoshima University
-
Nakagawa Masanori
Department Of Neurology And Gerontology Research Institute For Neurological Diseases And Geriatrics
-
Murata F
Kagoshima Medical Technology College
-
Murata Fusayoshi
Department Of Anatomy Kagoshima University Faculty Of Medicine
-
Nakamura T
Nagoya City Univ. Nagoya Jpn
-
Aoki Shinji
Research Laboratory Taisho Pharmaceutical Co. Ltd.
-
Yonezawa S
Dept. Hum. Pathol. Grad. Sch. Med. Dent. Sci. Kagoshima Univ.
-
Murata Fusayoshi
Departments Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sc
-
Sato Eiichi
岩手医科大学共通教育センター物理学科
-
佐藤 英一
宇宙航空研究開発機構 宇宙科研
-
Nakamura T
Kagoshima Institute Of Preventive Medicine
-
Hasui K
Division Of Persistent & Oncogenic Viruses Center For Chronic Viral Diseases Department Of Infec
-
Nakagawa Masanori
Department Of Astrophysics Nagoya University
-
Li Fang
Department Of Endocrinology Shanghai Tenth Hospital Affiliated To Tongji University
-
Li Fang
Department Of Pathology China Medical University
-
Nakagawa Masanori
The Third Department Of Internal Medicine Kagoshima University School Of Medicine Kagoshima
-
Li Fang
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University
関連論文
- Preparation of Gel-Core-Solid Lipid Nanoparticle: A Novel Way to Improve the Encapsulation of Protein and Peptide
- P1-66 胃底腺壁細胞におけるリン酸化エズリン分布の電顕免疫組織化学的検討(消化管,一般演題,第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー) 第39回日本臨床分子形態学会総会 合同学術集会)
- IB-30 胃酸分泌に関する細胞骨格の局在動態(細胞間結合,一般演題発表,第46回日本組織細胞化学会総会・学術集会)
- IB-7 壁細胞における酸分泌と膜移行変化(消化管,一般演題発表,第46回日本組織細胞化学会総会・学術集会)
- IB-30 Immunohistochemical analysis of gastric-acid secretion(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- IB-07 Acid secretion and transformation of gastric parietal cell(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Immunohistochemical Detection of the Cytoskeletal Components in Gastric Parietal Cells
- S1-2 Sialomucin, sulfomucin of alimentary tract cell and ultrastructure of mucous secreting cells(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- S1-2 消化管粘液分泌細胞のシアロムチン/スルフォムチンと超微構造(ムチン,シンポジウム1,第45回日本組織細胞化学会総会・学術集会)
- Immunohistochemical Analysis of Cell Proliferation and Suppression of Ameloblastoma with Special Reference to Plexiform and Follicular Ameloblastoma
- Expression of Mucins in the Human Fetal and Neonatal Stomach
- P-10-B Cytoskeletal components of gastric parietal cell(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY AND THE 35TH ANNUAL MEETING OF THE CLINICAL ELECTRON MICROSCOPY SOCIETY OF JAPAN)
- An Immunohistochemical Analysis of Gastric B-cell Lymphomas : Stromal Cells Exhibit Peculiar Histogenesis in Gastric B-cell Lymphomas
- P-10-B 胃底腺壁細胞における細胞骨格系(消化管,ポスター発表,第44回日本組織細胞化学会 第35回日本臨床電子顕微鏡学会 合同学術集会)
- 30-II-11 右頬粘膜部に発生した偽肉腫様癌腫の免疫組織化学的、超微形態学的検討(口腔,一般口演,第44回日本組織細胞化学会 第35回日本臨床電子顕微鏡学会 合同学術集会)
- 30-II-06 周辺性エナメル上皮腫の電子顕微鏡学的観察(口腔,一般口演,第44回日本組織細胞化学会 第35回日本臨床電子顕微鏡学会 合同学術集会)
- W2-4 今 高圧凍結の時(凍結技法の基礎と免疫組織化学への応用,ワークショップ2,第44回日本組織細胞化学会 第35回日本臨床電子顕微鏡学会 合同学術集会)
- An Immunohistochemical Analysis of Peripheral Blood Tissue Specimens from Leukemia Cells : Leukemic Cells of Adult T-cell Leukemia/Lymphoma Express p40Tax Protein of Human T-cell Lymphotropic Virus Type 1 When Entering Reproliferation
- Cytochemical investigation of gastric gland component cells with high-pressure freezing followed by freeze-substitution and hydrophilic resin embedding
- 細胞生物学講座 複合糖質の局在と機能
- P4-33 C1/S transition transcription factors in Adult T-cell leukemia/lymphoma
- Facial Muscular Atrophy in a Myasthenia Gravis Patient
- An Unbiased Search for Molecular Clouds in the Southern Galactic Warp
- The Small Heat Shock Protein αB-Crystallin Inhibits Differentiation-Induced Caspase 3 Activation and Myogenic Differentiation(Molecular and Cell Biology)
- A Functional Role of Intracellular Loops of Human Multidrug Resistance Protein 1
- P-54 ANALYSIS OF MOLECULAR MECHANISM OF MRP1 BY AGOSTEROL A, A MDR REVERSING SPONGEAN STEROL
- The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression
- Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
- Lembehsterols A and B, Novel Sulfated Sterols Inhibiting Thymidine Phosphorylase, from the Marine Sponge Petrosia strongylata
- Reversal of P-Glycoprotein and Multidrug-Resistance Protein-Mediated Drug Resistance in KB Cells by 5-0-Benzoylated Taxinine K.
- The expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor is correlated to angiogenesis in breast cancer
- Expression of Thymidine Phosphorylase in Human Gastric Carcinoma
- Association of High Proliferation in Adult T-cell Leukemia Cells With Apoptosis, and Expression of p53 Protein in Acute Type ATL
- Severe congestive heart failure with cardiac liver cirrhosis 10 years after orthotopic liver transplantation for familial amyloidotic polyneuropathy
- The Severity of Minamata Disease Declined in 25 Years : Temporal Profile of the Neurological Findings Analyzed by Multiple Logistic Regression Model
- Inhibitory Effect of α-Tocopherol on Methylmercury-Induced Oxidative Steress
- Clinical Investigation of the Lesions Responsible for Sensory Disturbance in Minamata Disease
- Parkinsonian Symptoms as an Initial Manifestation in a Japanese Patient with Acquired Immunodeficiency Syndrome and Toxoplasma Infection
- Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells
- P-226 NOVEL POLYKETIDES, SHIMALACTONES A AND B, FROM A MARINE-DERIVED FUNGUS EMERICELLA VARIECOLOR GF10
- P-98 CORTISTATINS A, B, C, AND D, ANTI-ANGIOGENIC STEROIDAL ALKALOIDS, FROM THE MARINE SPONGE CORTICIUM SIMPLEX
- P-63 SYNTHETIC STUDIES OF BASTADIN 6, AN ANTI-ANGIOGENIC SUBSTANCE FROM MARINE SPONGE
- Sesquiterpene Aminoquinones, from a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells
- Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells
- ASSESSMENT OF MITOCHONDRIAL GENE IN PROLIFERATIVE VITREORETINAL TISSUES FROM PATIENTS WITH FAMILIAL DIABETES MELLITUS
- Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells
- Statistically Significant Differences in the Number of CD24 Positive Muscle Fibers and Satellite Cells between Sarcoglycanopathy and Age-Matched Becker muscular Dystrophy Patients
- Developmental expression of mucin-associated antigens in human gastric mucosa(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- P-408 ヒト大腸癌の高肝転移株および低肝転移株と肝類洞内皮細胞の相互作用における超微形態学的検討
- Marine Natural Products. XXXVI. Biologically Active Polyacetylenes, Adociacetylenes A, B, C, and D, from an Okinawan Marine Sponge of Adocia sp.
- Cytochemistry of gastric parietal cell with high-pressure freezing followed by freeze-substitution
- Histochemical, immunohistochemical, and ultrastructural studies of gingival fibromatosis : a case report
- P4-03 Basal cell adenocarcinoma and basal cell adenoma of the salivary gland : an immunohistochemical and ultrastructual study
- P4-02 Histopathological and immunohistochemical studies of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster tongue carcinogenesis
- P3-11 Ontogeny of rat stomach : immunohistochemical analysis of constitutional cells
- P3-10 Immunohistochemical investigation of gastric parietal cell at the active and the resting phases of acid secretion
- Immunohistochemical Analysis of the Pathogenicity of Helicobacter pylori Infection : Excess Nitric Oxide Induced Indirectly by Lewis X and Y is the Cause of the Pathogenicity of Helicobacter pylori Infestation in the Stomach
- A-18 胃底腺各構成細胞の鑑別染色について(消化器1,一般演題(口演発表),第41回 日本組織細胞化学会総会・学術集会)
- PP731 血管新生因子(Thymidine Phosphorylase)肝転移における接着, 浸潤に与える影響
- 高圧凍結の組織化学への応用
- P I-51 顆粒白血球硫酸化プロテオグリカンの局在
- P I-45 摂食および絶食期における胃底腺壁細胞のプロトンポンプと細胞骨格
- Fabry 病および神崎病におけるリソゾーム内蓄積物質の免疫組織電顕およびレクチン組織電顕的解析
- 分泌および休止相における胃底腺壁細胞 -高圧凍結・凍結置換法を用いた免疫組織化学-
- 話題 解剖学・細胞生物学/高圧凍結技法--新しい生体構造の観察法
- The assessment of cell proliferation during 9, 10-dimethyl-1, 2-benzanthracene-induced hamster tongue carcinogenesis by means of histone H3 mRNA in situ hybridization
- Expression of epithelial growth factor receptor and its two ligands, transforming growth factor-alpha and epithelial growth factor, in normal and neoplastic squamous cells in the vulva : an immunohistochemical study
- Expression of Mucin 1(MUC1)in Benign, Premalignant and Malignant Vulvar Tumors
- LYSOSOMAL GLYCOGEN STORAGE DISEASE WITHOUT ACID MALTASE DEFICIENCY : LECTIN HISTOCHEMICAL STUDIES
- Logistic Model Analysis of Neurological Findings in Minamata Disease and the Predicting Index
- Adult onset limb-girdle type mitochondrial myopathy with a mitochondrial DNA np8291 A-to-G substitution
- Facioscapulohumeral Muscular Dystrophy: Clinical Diversity and Genetic Abnormalities in Japanese Patients
- Nationwide Survey of Neurologic Manifestations of Acquired Immunodeficiency Syndrome in Japan
- A Hemophiliac with Human Immunodeficiency Virus (HIV)-1-Associated Dementia Complex
- IMMUNOHISTOCHEMICAL STUDY OF CYTOCHROME C OXIDASE WITH A MONOCLONAL ANTIBODY IN MITOCHONDRIAL MYOPATHY
- Molecular Analysis of Hereditary Deficiency of the Third Component of Complement (C3) in TWO Sisters
- Phenotypes of X-linked Charcot-Marie-Tooth disease and altered trafficking of mutant Connexin 32 (GJB1)
- Differences in Substrate Specificity among Glutathione Conjugates (GS-X) Pump Family Members: Comparison between Multidrug Resistance-associated Protein and a Novel Transporter Expressed on a Cisplatin-resistant Cell Line (KCP-4)
- Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
- Obesity affects expression of progesterone receptors and node metastasis of mammary carcinomas in postmenopausal women without a family history
- Histological and biological characteristics of microinvasion in mammary carcinomas 【less than or equal】 2 cm in diameter
- Immunohistochemical studies on expression of human vascular smooth muscle myosin heavy chain isoforms in normal mammary glands, benign mammary disorders and mammary carcinomas
- Novel Neuronal Nitric Oxide Synthase(nNOS)Selective Inhibitor, Aplysinopsin-Type Indole Alkaloid, from Marine Sponge Hyrtios erecta
- Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.
- Influence of N-Terminal Peptide and Oligosaccharide on the Clearance of t-PA
- Endogenous Tumor Necrosis Factor Inhibits the Cytotoxicity of Exogenous Tumor Necrosis Factor and Adriamycin in Pancreatic Carcinoma Cells
- Reversal of Tumor Necrosis Factor Resistance in Tumor Cells by Adriamycin via Suppression of Intracellular Resistance Factors
- Absorption of Ibuprofen Coated by Anhydrous Silicic Acid
- Refinement of a locus for autosomal dominant hereditary motor and sensory neuropathy with proximal dominancy (HMSN-P) and genetic heterogeneity
- 高圧凍結 : 過去,現在,未来
- 固定法 3.高圧凍結
- 高圧凍結:過去, 現在そして未来
- Influence of Sugar Chain on Fibrin Affinity of Recombinat t-PA
- Marine Natural Products. XXXVIII. Absolute Stereostructures of Altohyrtins A, B, and C and 5-Desacetylaltohyrtin A, Potent Cytotoxic Macrolides, from the Okinawan Marine Sponge Hyrtios altum
- Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients
- Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus
- Cytotoxicity of Neutrophil-Induced Superoxide to Isolated Pancreatic Acinar Cells
- Is temporal slow wave on EEG a useful diagnostic tool in vascular depression?
- II-C-02 Reduced expression of excitatory amino acid transporter-2 (EAAT-2) and activation of microglia in the cerebral cortex of AIDS patients(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- SET-REPRESENTATION OF A QUIVER AND RELATIONSHIP WITH LINEAR-REPRESENTATION