Immunohistochemical Analysis of the Pathogenicity of Helicobacter pylori Infection : Excess Nitric Oxide Induced Indirectly by Lewis X and Y is the Cause of the Pathogenicity of Helicobacter pylori Infestation in the Stomach
スポンサーリンク
概要
- 論文の詳細を見る
Inducible nitric oxide synthase (iNOS) is expressed in the germinal centers (GCs) of mucosa-associated lymphoid tissue (MALT) and regional lymph nodes (RLNs) in the stomachs of patients with Helicobacter pylori (HP)-related ulcer. This study used immunohistochemistry to deduce how the iNOS was expressed and what the iNOS induced on the MALT in four cases. HP bodies were labeled with anti-HP, anti-Lewis X and Y, and anti-IgH antibodies in the surface mucous coat and in the glands. Lewis X or V was detected in regenerative, metaplastic and atrophic glandular epithelial cells and GCs of RLNs. The expression of iNOS was recognized again in some glandular epithelial cells and in the GCs of the MALT and RLNs. The developed MALT included many IgM+ CD5- cells in the background of an ordinary mucosal immunity. Pseudonodular growth of the IgM+ CD5- cells was recognized in one case. It is suggested that Lewis X and Y from HP bodies induced iNOS in the GCs. Dominant IgM+ CD5- cells in the MALT suggested that excess nitric oxide (NO) produced by iNOS disturbed anti-HP B-cell immunity development in the GCs. As NO is also a mutagen, the IgM+ CD5- B-cells' pseudonodular growth might explain MALT-type lymphomagenesis.
- 日本組織細胞化学会の論文
著者
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村田 長芳
鹿児島医療技術専門学校
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Hasui Kazuhisa
The Second Department of Anatomy, Kagoshima University Faculty of Medicine
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Jia Xin-Shan
Department of Pathology, China Medical University
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Nakamura Takao
Kagoshima institute of Preventive Medicine
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Yonezawa Suguru
The Second Department of Pathology, Kagoshima University Faculty of Medicine
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Izumo Shuji
Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Kagoshi
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Murata Fusayoshi
The Second Department of Anatomy, Kagoshima University Faculty of Medicine
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Jia Xin-shan
鹿児島大学 2解剖
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Jia Xin-shan
Department Of Pathology China Medical University
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Nakagawa Masanori
京都府立医科大学 神経内科学
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Nakagawa Masanori
Third Department Of Internal Medicine Kagoshima University Faculty Of Medicine
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YASHIKI Shinji
Department of Virology, Kagoshima University School of Medicine
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JIA Xin
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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NAKAGAWA MASANORI
The Third Department of Internal Medicine, Kagoshima University Faculty of Medicine
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Izumo S
Division Of Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Diseases Kagoshima
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Izumo Shuji
Division Of Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Diseases Kagoshima
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Izumo Shuji
Molecular Pathology And Genetic Epidemiology Center For Chronic Viral Disease Kagoshima University
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Nakagawa Masanori
Department Of Neurology And Gerontology Research Institute For Neurological Diseases And Geriatrics
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Murata F
Kagoshima Medical Technology College
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Murata Fusayoshi
Department Of Anatomy Kagoshima University Faculty Of Medicine
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Sato Eiichi
The Second Department of Pathology
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Nakamura T
Nagoya City Univ. Nagoya Jpn
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Yonezawa S
Dept. Hum. Pathol. Grad. Sch. Med. Dent. Sci. Kagoshima Univ.
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Murata Fusayoshi
Departments Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sc
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Jia Xin
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Yashiki S
Department Of Virology Faculty Of Medicine Kagoshima University
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Nakamura T
Kagoshima Institute Of Preventive Medicine
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Hasui K
Division Of Persistent & Oncogenic Viruses Center For Chronic Viral Diseases Department Of Infec
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Yashiki Shinji
Department Of Virology
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Nakagawa Masanori
The Third Department Of Internal Medicine Kagoshima University
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Nakagawa Masanori
The Third Department Of Internal Medicine Kagoshima University School Of Medicine Kagoshima
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