Association of High Proliferation in Adult T-cell Leukemia Cells With Apoptosis, and Expression of p53 Protein in Acute Type ATL
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概要
- 論文の詳細を見る
Proliferation, apoptosis and p53 protein expression in adult T-cell leukemia (ATL) cells were investigated. Twenty peripheral blood tissue specimens (PBTS) comprising 7 cases of acute type ATL, 7 cases of chronic type ATL and 6 other leukemias were examined by means of antigen retrieval and the polymer method employing anti-Ki67 antigen (MIB-1), anti-cleaved caspase-3, anti-single stranded DNA and three kinds of anti-p53 protein antibodies including DO7. Most acute and chronic cases of ATL included more than 10% MIB-1-positive proliferating leukemia cells and more than 1% cleaved caspase-3-positive apoptotic cells. Some cells which were positive for both MIB-1 and anti-cleaved caspase-3 antibody were observed in acute type ATL. Nuclear deposition of p53 protein labeled by DO7 was often found in acute type (p < 0.05). Within the medium-sized population of ATL cell nuclei, DO7-positive ATL cells had a smaller nuclear area factor (long axis x short axis) than DO7-negative ATL cells. A few proliferating ATL cells entered apoptosis, and the appearance of a subclone of ATL cells with nuclear deposition of p53 protein labeled by DO7 characterized acute type. [J Clin Exp Hematopathol 48(1) : 1-10, 2008]
- 2008-05-01
著者
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UTSUNOMIYA Atae
Department of Hematology, Imamura Bun-in Hospital
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村田 長芳
鹿児島医療技術専門学校
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村田 長芳
鹿児島大学 第1外科
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Murata Fusayoshi
Kagoshima Univ.
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UTSUNOMIYA Atae
Jiaikai Imamura Hospital Branch Hospital
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WANG Jia
Divsion of Persistent & Oncogenic Viruses (Center for Chronic Viral Diseases), Field of Infection an
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HASUI Kazuhisa
Divsion of Persistent & Oncogenic Viruses (Center for Chronic Viral Diseases), Field of Infection an
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JIA Xinshan
Department of Pathology, China Medical University
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MATSUYAMA Takami
Department of Immunology, Field of Infection and Immunity, Course of Health Research, Kagoshima Univ
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Utsunomiya A
Department Of Hematology Imamura-bunin Hospital
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Utsunomiya Atae
Department Of Hematology Imamura Bun-in Hospital
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Murata F
Kagoshima Medical Technology College
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Murata Fusayoshi
Department Of Anatomy Kagoshima University Faculty Of Medicine
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Murata Fusayoshi
Kagoshima Medical Technology College
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Murata Fusayoshi
Departments Of Structural Cell Biology Kagoshima University Graduate School Of Medical And Dental Sc
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Matsuyama Takami
Division Of Immunology Department Of Infection And Immunity Graduate School Of Medical And Dental Sc
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Matsuyama Takami
Department Of Immunology Faculty Of Medicine Kagoshima University
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Wang Jia
Division Of Persistent & Oncogenic Viruses Center For Chronic Viral Diseases Department Of Infec
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Hasui K
Division Of Persistent & Oncogenic Viruses Center For Chronic Viral Diseases Department Of Infec
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Jia Xinshan
Department Of Pathology China Medical University
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