In Vitro and in Vivo Antifungal Activities of the Eight Steroid Saponins from Tribulus terrestris L. with Potent Activity against Fluconazole-Resistant Fungal(Pharmacology)
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概要
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Antifungal activity of natural products is being studied widely. Saponins are known to be antifungal and antibacterial. We have isolated eight steroid saponins from Tribulus terrestris L., namely TTS-8, TTS-9, TTS-10, TTS-11, TTS-12, TTS-13, TTS-14 and TTS-15. TTS-12 and TTS-15 were identified as tigogenin-3-O-β-D-xylopy-ranosyl(1→2)-[β-D-xylopyranosyl(1→3)]-β-D-glucopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-galactopy-ranoside and tigogenin-3-O-β-D-glucopyranosyl(1→2)-[β-D-xylopyranosyl(1→3)]-β-D-glucopyranosyl(1→4)-β-D-galactopyranoside, respectively. The in vitro antifungal activities of the eight saponins against six fluconazole-resistant yeasts, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida krusei, and Cryptococcus neoformans were studied using microbroth dilution assay. The results showed that TTS-12 and TTS-15 were very effective against several pathogenic candidal species and C. neoformans in vitro. It is noteworthy that TTS-12 and TTS-15 were very active against fluconazole-resistant C. albicans (MIC_<80>=4.4, 9.4μg/ml), C. neoformans (MIC_<80>=10.7, 18.7μg/ml) and inherently resistant C. krusei (MIC_<80>=8.8, 18.4μg/ml). So in vivo activity of TTS-12 in a vaginal infection model with fluconazole-resistant C. albicans was studied in particular. Our studies revealed TTS-12 also showed in vivo activities against fluconazole-resistant yeasts. In conclusion, steroid saponins TTS-12 and TTS-15 from Tribulus terrestris L. have significant in vitro antifungal activity against fluconazole-resistant fungi, especially TTS-12 also showed in vivo activity against fluconazole-resistant C. albicans.
- 社団法人日本薬学会の論文
- 2005-12-01
著者
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GAO Ping
Department of Prosthodontics, Dental College and Hospital of Tianjin Medical University
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ZHANG Jun
Department of Pharmacology, Tokyo Medical University
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Sun Hui
Department Of Orhopeadics Mount Sinai School Of Medicine
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Wang Yan
Department Of Electrical Engineering National Cheng Kung University
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Cao Yong
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Cao Yong
School Of Pharmacy Second Military Medical University
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Gao Ping
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Gao Ping
School Of Pharmacy Second Military Medical University
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Gao Ping
Department Of Oncology Biomedical Research Center Osaka University Graduate School Of Medicine
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Sun Hui
Department Of Biotechnology College Of Food Science Shanghai Fisheries University
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XU Zheng
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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An Mao
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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YAN Lan
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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CHEN Hai
Department of Natural Products Chemistry, College of Pharmacy, Second Military Medical University
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JIA Xin
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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JIANG Yuan
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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Jiang Yuan
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Jiang Yuan
School Of Pharmacy Second Military Medical University
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WANG Yan
School of Pharmacy, Second Military Medical University
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Wang Yan
Department Of Cardiovascular Sciences Oita University School Of Medicine
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Zhang Jun
Department Of Chemistry Korea University
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An Mao-mao
Department Of Clinical Pharmacology Chinese People's Liberation Army General Hospital
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An Mao
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Yan Lan
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Jia Xin
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Chen Hai
Department Of Natural Products Chemistry College Of Pharmacy Second Military Medical University
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Xu Zheng
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Cao Yong-Bing
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Jian Yuan
School Of Pharmacy Second Military Medical University
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Wang Yan
School Of Pharmacy Second Military Medical University
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Cao Yong
Department Of Chemistry Fudan University
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Zhang Jun
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Cao Ying
School Of Pharmacy Second Military Medical University
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Wang Yan
Dep. Of Pharmacognosy School Of Pharmacy Second Military Medical Univ. Chn
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Sun Hui
Department Of Anatomy And Cell Biology Indiana University School Of Medicine
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Xu Zheng
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Zhang Jun
Department Of Cardiology Renmin Hospital Of Wuhan University Wuhan Cardiovascular Research Institute
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Zhang Jun
Department Of Bioengineering And Robotics Graduate School Of Engineering Tohoku University
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Xu Zheng
Department Of Orthopaedic Surgery University Of California At San Francisco
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Cao Yong-bing
School Of Pharmacy Second Military Medical University
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Gao Ping-hui
School Of Pharmacy Second Military Medical University
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Zhang Jun-dong
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Xu Zheng
Department Of Biochemistry And National Laboratory Of Pharmaceutical Biotechnology Nanjing Universit
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Wang Yan
Department Of Biology Graduate University Of Chinese Academy Of Sciences
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An Mao
Department Of Clinical Pharmacology Chinese People's Liberation Army General Hospital
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Zhang Jun
Department Of Anesthesiology Huashan Hospital Fudan University
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