Involvement of Peroxiredoxin I in Protecting Cells from Radiation-Induced Death
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概要
- 論文の詳細を見る
Peroxiredoxin I (Prx-I), a key member of the peroxiredoxin family, reduces peroxides and equivalents through the thioredoxin system. Our previous work has shown that expression of Prx-I in mammalian cells increases following ionizing radiation (IR), indicating that Prx-I actively responds to IR-induced reactive oxygen species (ROS) and suggesting that Prx-I plays an important role in protecting cells from IR-induced death. To test this hypothesis, we suppressed the expression of Prx-I in SW480 cells by RNA interference. Our results show that IR induces the expression of Prx-I in SW480 cells in a dose- and time-dependent manner. The recombinant siRNA vector targeting Prx-I dramatically reduced the expression of Prx-I in SW480 cells. When Prx-I was knocked down in SW480 cells, the cells exhibited a decreased growth rate, a reduced antioxidant capability following IR and became more sensitive to IR-induced apoptosis. Together, our results demonstrate that Prx-I plays an important role in protecting cells from IR-induced cell death, which might be through scavenging IR-induced ROS in the cells.
- 日本放射線影響学会の論文
- 2005-09-30
著者
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Wang Yan
Department Of Electrical Engineering National Cheng Kung University
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Wang Yan
Department Of Medical Genetics Third Military Medical University
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WANG Fengchao
Institute of Combined Injury, Third Military Medical University
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ZHANG Bo
Combined Injury Institute of Third Military Medical University, State Key Laboratory of Trauma, Burn
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SU Yongping
Combined Injury Institute of Third Military Medical University, State Key Laboratory of Trauma, Burn
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AI Guoping
Combined Injury Institute of Third Military Medical University, State Key Laboratory of Trauma, Burn
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WANG Tao
Combined Injury Institute of Third Military Medical University, State Key Laboratory of Trauma, Burn
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WANG Fengchao
Combined Injury Institute of Third Military Medical University, State Key Laboratory of Trauma, Burn
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Wang Yan
Department Of Cardiovascular Sciences Oita University School Of Medicine
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Zhamg Bo
Institute Of Combined Injury State Key Laboratory Of Trauma Burns And Combined Injury Third Military
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Ai Guoping
State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre
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Su Yongping
State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre
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Wang Fengchao
Combined Injury Institute Of Third Military Medical University State Key Laboratory Of Trauma Burns
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Wang Tao
Cold And Arid Regions Environmental And Engineering Res. Inst. Chinese Acad. Sci. Lanzhou Chn
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Wang Yan
Department Of Biology Graduate University Of Chinese Academy Of Sciences
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