Effect of Pore Former on the Properties of Casted Film Prepared from Blends of Eudragit^[○!R] NE 30D and Eudragit^[○!R] L30 D-55

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概要

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• The casted films of aqueous dispersions of Eudragit^[○!R] NE30 D and Eudragit^[○!R] L30 D-55 containing pore former were prepared. The study investigated the influence of pore former on basic model drug clarithromycin release, water uptake and water vapor permeability from casted film prepared from the blends of neutral polymer dispersion of Eudragit^[○!R] NE30 D and enteric polymer dispersion of Eudragit^[○!R] L30 D-55. This study was concluded that pore former hydroxypropyl methyl cellulose, lactose, polyethylene glycol (PEG) and polyvinyl pyrrolidon (PVP) was released at the beginning of the release process, the rate and extent of water uptake of the polymeric films were much higher in phosphate buffer pH 6.8 than in pH 5.0 and the concentration of pore former have a significant influence on the permeability to water vapour.

• 公益社団法人日本薬学会の論文
• 2007-08-01

著者

• Wang Jing

  Department of Environmental Health, School of Medicine, University of Yamanashi

• Wang Yan

  Department Of Electrical Engineering National Cheng Kung University

• Wang Jing

  中華人民共和国

• Wang Yan

  Department Of Cardiovascular Sciences Oita University School Of Medicine

• Wang Jing

  Medical College Of Chinese People's Armed Police Forces

• Wang Meng

  School Of Pharmacy Shanghai Jiao Tong University

• Wang Jing

  Department Of Echocardiography Union Hospital Tongji Medical College Huazhong University Of Science

• ZHANG Xiangrong

  Department of Pharmaceutics, Shenyang Pharmaceutical University

• WANG Yanjiao

  Department of Pharmaceutics, Shenyang Pharmaceutical University

• LI Sanming

  Department of Pharmaceutics, Shenyang Pharmaceutical University

• Wang Yan

  Dep. Of Pharmacognosy School Of Pharmacy Second Military Medical Univ. Chn

• Zhang Xiangrong

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Wang Yan

  Department Of Biology Graduate University Of Chinese Academy Of Sciences

• Wang Yanjiao

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Li Sanming

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Wang Jing

  Department Of Biological Sciences Texas Tech University

• Wang Jing

  School of Pharmacy, Shanghai Jiao Tong University

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