Design, Synthesis and Cytotoxicity of Novel Podophyllotoxin Derivatives
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概要
- 論文の詳細を見る
A series of novel podophyllotoxin derivatives were designed using association strategy and synthesized by coupling either podophyllotoxin (1) or 4β-amino podophyllotoxin (3) with substituted indol-3-yl-glyoxyl chlorides. Their structures were identified using spectroscopic techniques. These novel derivatives have been evaluated for cytotoxicity in vitro against four human cancer cell lines with comparison to the parent compounds 1,3 and indibulin (2). Some of the compounds (7a, 7c) showed comparable cytotoxicity to that of podophyllotoxin.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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Wang Jing
中華人民共和国
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Yu Peng-fei
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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Yang Na
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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CHEN Hong
Staff Room of Pharmacognosy, Medical College of Chinese People's Armed Police Forces
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WANG Jing
Staff Room of Pharmacognosy, Medical College of Chinese People's Armed Police Forces
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HE Chun-Xian
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering
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CAO Bo
Staff Room of Pharmacognosy, Medical College of Chinese People's Armed Police Forces
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LI Min
Staff Room of Pharmacognosy, Medical College of Chinese People's Armed Police Forces
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LEI Zhi-Yong
Staff Room of Pharmacognosy, Medical College of Chinese People's Armed Police Forces
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CHENG Mao-Sheng
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering
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Li Min
State Key Lab. Of Natural And Biomimetic Drugs Peking Univ.
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He Chun-xian
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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Chen Hong
Medical College Of Chinese People's Armed Police Forces:tianjin Key Laboratory For Biomarkers O
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Wang Jing
Medical College Of Chinese People's Armed Police Forces
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Wang Meng
School Of Pharmacy Shanghai Jiao Tong University
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Lei Zhi-yong
Staff Room Of Pharmacognosy Medical College Of Chinese People's Armed Police Forces
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Cao Bo
Medical College Of Chinese People's Armed Police Forces
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Cheng Mao-sheng
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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Wang Jing
Staff Room Of Pharmacognosy Medical Coll. Of Chinese People's Armed Police Forces
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Li Min
Staff Room Of Pharmacognosy Medical College Of Chinese People's Armed Police Forces
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Wang Jing
School of Pharmacy, Shanghai Jiao Tong University
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