Cytotoxic Germacranolide Sesquiterpene from Inula cappa
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概要
- 論文の詳細を見る
A new germacranolide, inulacappolide (1), was isolated from the EtOH extract of the whole plant of Inula cappa along with 16 known compounds. The structure of inulacappolide was a rare 1(10)-saturated type of germacran-6,12-olide, identified as 2α-acetoxy-3β-hydroxy-9β-angeloyloxygermacra-4-en-6α,12-olide by spectral analysis (IR, HR-ESI/MS, ^1H-NMR, ^<13>C-NMR, HMQC, HMBC, NOESY). In vitro, it showed antiproliferative effects against human cervical cancer HeLa, human leukemia K562 and human nasopharyngeal carcinoma KB cell lines with IC_<50> values of 1.2μM, 3.8μM and 5.3μM, respectively.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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CHEN Hong
Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University
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Xie Hong-gang
Institute Of Medicinal Plant Development Chinese Academy Of Medical Sciences And Peking Union Medica
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Zhang Hong-wu
Institute Of Medicinal Plant Department Chinese Academy Of Medical Sciences And Peking Union Medical
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Zhang Hong-wu
Institute Of Medicinal Plant Development Chinese Academy Of Medical Sciences And Peking Union Medica
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Chen Hong
Medical College Of Chinese People's Armed Police Forces:tianjin Key Laboratory For Biomarkers O
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Chen Hong
Department Of Biology Shenyang Teachers' College:(present Address)biological Laboratory Sapporo
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Zou Zhong-Mei
Institute of medicinal plant Department, Chinese Academy of Medical Sciences and Peking Union Medica
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CAO Bo
Department of Pharmacology, Medical College of Chinese People's Armed Police Forces
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Zou Zhong-mei
Institute Of Medicinal Plant Development Chinese Academy Of Medical Sciences And Peking Union Medica
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Zou Zhong
Institute Of Medicinal Plants Development Chinese Academy Of Medical Sciences And Peking Union Medic
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Zou Zhong-mei
Institute Of Medicinal Plant Department Chinese Academy Of Medical Sciences And Peking Union Medical
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Cao Bo
Medical College Of Chinese People's Armed Police Forces
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Cao Bo
Department Of Hygienic Toxicology Preventive Medicine College Third Military Medical University
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