Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin
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概要
- 論文の詳細を見る
Parkinsons disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) with the presence of α-synuclein inclusions termed Lewy bodies. The aggregation of α-synuclein into oligomeric species affects neuronal viability, having a causal role in the development of PD. The neuroprotective effects of protocatechuic acid (PAc) have been reported. However, the effects of PAc on tyrosine hydroxylase (TH) and α-synuclein in rat pheochromocytoma (PC12) cells treated with 1-methyl-4-phenylpyridinium ion (MPP+) remains unclear. In this study, we demonstrated that PAc inhibited the cytotoxicity, apoptotic morphology, reduction of TH expression and abnormal oligomeration of α-synuclein in PC12 cells treated with MPP+. Taken together, our results indicate that the neuroprotective effects of PAc on PC12 cells treated with MPP+ is related to the inhibition of the oligomerization of α-synuclein.
- 日本薬学会の論文
著者
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Pu Xiao-Ping
State Key Laboratory of Natural and Biomimetic Drugs, Peking University
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XU Man
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Me
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Xu Man
Department Of Pathology First Affiliated Hospital And College Of Basic Medical Sciences Of China Med
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Zhang Hong-Ning
State Key Laboratory of Natural and Biomimetic Drugs, Peking University
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An Chun-Na
State Key Laboratory of Natural and Biomimetic Drugs, Peking University
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Guo De-An
Department of Natural Drugs, School of Pharmaceutical Science, Peking University
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Li Min
State Key Laboratory of Natural and Biomimetic Drugs, Peking University
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Li Min
State Key Lab. Of Natural And Biomimetic Drugs Peking Univ.
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Xu Man
Department of Natural Drugs, School of Pharmaceutical Science, Peking University
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