Expression of the Parkinsons Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation

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概要

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• Neural stem cells (NSCs) arise through neurogenesis, and comprise all newly-formed neurons in the central and peripheral nervous systems. DJ-1 is associated with autosomal recessive familial Parkinsons disease (PD). The relationship between DJ-1 and NSC proliferation may shed light on the underlying pathogenesis of, and potential treatments for, PD. To investigate the relationship between DJ-1 and NSCs, embryonic cortical NSCs were isolated and cultured from E14 fetal rats. Immunocytochemistry, flow cytometry, and immunohistochemistry were applied to evaluate DJ-1 expression in proliferating NSCs. We found that DJ-1 was co-expressed with nestin, a marker of progenitors, during NSC proliferation from days 1—7. The present results suggest that DJ-1 is co-expressed with nestin in NSCs during proliferation.

著者

• Pu Xiao-Ping

  State Key Laboratory of Natural and Biomimetic Drugs, Peking University

• Yan Hui

  State Key Research Laboratory of Natural and Biomimetic Drugs, Peking University

• Pu Xiao-Ping

  State Key Research Laboratory of Natural and Biomimetic Drugs, Peking University

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• Expression of the Parkinsons Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation
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