Effects of Benzo[a]pyrene on Autonomic Nervous System of Coke Oven Workers

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概要

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• Objectives are to investigate the effects of benzo[a]pyrene (B[a]P) on the autonomic nervous system of coke oven workers. One hundred eightyfour coke oven workers were divided into 3 groups according to their working sites (coke oven bottom group, coke oven side group and coke oven top group), and 93 referents were recruited. B[a]P monitored by air sampling pumps as well as urinary 1-hydroxypyrene (1-OH-Py) was determined by high performance liquid chromatograph with a fluorescence detector (HPLCFD). The autonomic nervous system (ANS) function was determined by 4 tests: Valsalva Manoeuvre heart rate variation (HR-V), variation of heart rate when breathing deeply (HR-DB), variation of heart rate when instantly standing up (HR-IS, including RR30:15 and RRmax:min) and variation of blood pressure when instantly standing up (BP-IS). The B[a]P mean concentrations in coke oven bottom, coke oven side and coke oven top were 19, 185 and 1,623 ng/m^3, respectively. The levels of urinary 1-OH-Py were markedly higher in the 3 exposed groups than that in the referent group (p<0.01). No significant difference was found in each group between smokers and nonsmokers (p>0.05). Compared with referents, HR-V decreased significantly in coke oven workers (p<0.01), representing modulation of parasympathetic nervous function. However, no statistical differences were found in HR-DB, RR30:15, RRmax:min and BP-IS between the exposed groups and the control group (p>0.05). HR-V decreased with the increment of 1-OH-Py (p<0.05), and results of multiple linear stepwise regression demonstrated that external exposure level and duration of education entered the HR-V model; age was a significant factor of HR-DB and RRmax:min, but no variable was involved in RR30:15 and BP-IS regression. Benzo[a]pyrene affects the autonomic nervous function of coke oven workers mainly by downregulating the parasympathetic nervous function.

• 社団法人日本産業衛生学会の論文

著者

• Wang Fang

  Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

• Wang Jing

  Department of Environmental Health, School of Medicine, University of Yamanashi

• Wang Fang

  Department Of Electronics Engineering And Institute Of Electronics National Chiao Tung University

• Niu Qiao

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• ZHANG Ling

  Department of Physics and State Key Laboratory for Crystal Materials, Shandong University

• Song Jing

  Department Of Biochemistry The Chinese University Of Hong Kong

• Zhang Ling

  Department Of Molecular Epidemiology Medical Research Institute Tokyo Medical And Dental University

• Zhang Hong-mei

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Zhang Qin-li

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Zhao Jie

  Department Of Chemistry Faculty Of Engineering Yamagata University:department Of Applied Chemistry N

• Zhao Jie

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Gioacchino Mario

  Department Of Medicine And Science Of Ageing University 'g. D' Annuzio Of Chieti And Pesca

• Shi Ying-tao

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Wang Lin-ping

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Antonucci Andrea

  Department Of Medicine And Science Of Ageing University 'g. D' Annuzio Of Chieti And Pesca

• NIE Jie-Sheng

  Department of Occupational Health, School of Public Health, Shanxi Medical University

• LIU Hui-Jun

  Department of Occupational Health, School of Public Health, Shanxi Medical University

• XUE Cui-E

  Division of Clinical Hematology Examination, Fenyang College, Shanxi Medical University

• Xue Cui-e

  Division Of Clinical Hematology Examination Fenyang College Shanxi Medical University

• Liu Hui-jun

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Nie Jie-sheng

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Wang Jing

  Department Of Echocardiography Union Hospital Tongji Medical College Huazhong University Of Science

• Song Jing

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Zhang Ling

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Wang Fang

  Department Of Chemistry Box 8204 North Carolina State University

• Wang Fang

  Department Of Occupational Health School Of Public Health Shanxi Medical University

• Zhang Ling

  Department Of Cardiovascular Physiology Faculty Of Medicine Kagawa University

• Niu Qiao

  Department Of Occupational And Environmental Health Shanxi Medical University

• Wang Jing

  Department Of Biological Sciences Texas Tech University

• Nie Ji-Sheng

  Department of Occupational Health, School of Public Health, Shanxi Medical University

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