Associations Between Polymorphisms in the Glucocorticoid-Receptor Gene and Cardiovascular Risk Factors in a Chinese Population
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概要
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Background: Glucocorticoid is an important regulator of energy homeostasis. Glucocorticoid receptor (GR) gene polymorphisms that contribute to variability in glucocorticoid sensitivity have been identified. We explored the associations of single-nucleotide polymorphisms (SNPs) of the GR gene with traditional cardiovascular risk factors in the Chinese Han population.<BR>Methods: We recruited 762 consecutive adults who underwent a regular physical examination at Beijing Xuanwu Hospital. Blood pressure, glucose, lipid levels (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides), body mass index (BMI), and waist-to-hip ratio were measured. Fourteen tag SNPs and 5 functional SNPs were selected and genotyped using the high-throughput Sequenom genotyping platform. Differences between genotypes/alleles for each SNP were adjusted for sex and age and tested using a general linear model procedure. Various models of inheritance, including additive, dominant, and recessive, were tested.<BR>Results: Among the 19 SNPs examined, 5 markers were associated with cardiovascular risk factors. The rs41423247 GG genotype and the rs7701443 AA genotype were associated with higher BMI and systolic blood pressure (P < 0.0004), and the rs17209251 GG genotype was associated with higher systolic blood pressure (P < 0.0004). Lower systolic blood pressure, total cholesterol, and LDL cholesterol were observed among rs10052957 A allele carriers (P < 0.0004), and lower plasma glucose and LDL-cholesterol concentrations were observed among rs2963156 TT carriers (P < 0.0004).<BR>Conclusions: Polymorphism of the GR gene was associated with cardiovascular risk factors and may contribute to susceptibility to cardiovascular disease.
著者
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Liu You-qin
Physical Examination Center Beijing Xuanwu Hospital Capital Medical University
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He Yan
Department Of Biology Genetics Institute The Plant Molecular And Cellular Biology Program University
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Zhang Ling
Department Of Cardiovascular Physiology Faculty Of Medicine Kagawa University
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Zhang Jie
Department Of Anesthesia The First Affiliated Hospital Of Zhengzhou University
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LIU You-Qin
Physical Examination Center, Beijing Xuanwu Hospital, Capital Medical University
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Wu Li-Juan
Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University
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Yan Yu-Xiang
Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University
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Wang Wei
Department of Anesthesiology, China-Japan Friendship Hospital, the Chinese Ministry of Health, Beijing, China
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Dong Jing
Physical Examination Center, Beijing Xuanwu Hospital, Capital Medical University
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Shao Shuang
Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University
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