Protective Effects of Breviscapine on Ischemic Vascular Dementia in Rats(Pharmacology)

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概要

• 論文の詳細を見る

• Breviscapine, a traditional Chinese medicine, is extensively used in clinic to treat cardiovascular diseases and cerebrovascular injury. In this study, we demonstrated the effects of breviscapine on vascular dementia (VD) rats, which were mimicked by permanent occlusion of bilateral common carotid arteries. Breviscapine (2mg/kg for 14d) improved the performance of learning and memory of VD rats in Morris water maze, decreased the level of lipid peroxidation and free radicals, and attenuated the pathological alterations, such as nuclear shrink, cellular edema and irregular arrangement of pyramidal layer in the hippocampal CA_1 area. In vitro experiment, breviscapine (50μg/l) protected cortical neuron from injury and decreased intracellular calcium overloading induced by H_2O_2 (10mM). The results suggest that breviscapine has therapeutic effect on cerebral ischemia and vascular dementia.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• WANG Wei

  Department of Mechanical Engineering, Chiba University

• Xiong Zhe

  Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

• Wang Fang

  Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

• Xiong Zhe

  Department Of Pharmacology Tongji Medical College Huazhong University Of Science And Technology

• Wang Fang

  Inst. Of Geology And Geophysics Chinese Acad. Of Sci. Beijing Chn

• Wang Fang

  Department Of Electronics Engineering And Institute Of Electronics National Chiao Tung University

• CHEN Jianguo

  Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University

• Chen Jianguo

  Department Of Epidemiology Medical Research Institute Tokyo Medical And Dental University

• Chen Jianguo

  Department Of Pharmacology Tongji Medical College Huazhong University Of Science And Technology:hube

• Liu Chao

  Department Of Computer Science National Chung-hsing University

• Xiong Zhe

  Dep. Of Pharmacology Tongji Medical Coll. Huazhong Univ. Of Sci. And Technol.

• LI Cailian

  Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

• WANG Jianzhi

  Hubei Provincial Key Laboratory for Neural Diseases

• Li Cailian

  Department Of Pharmacology Tongji Medical College Huazhong University Of Science And Technology

• Wang Wei

  Department Of General Surgery Shanghai Chang Zheng Hospital Second Military Medical University

• Wang Fang

  Department Of Chemistry Box 8204 North Carolina State University

• Wang Wei

  Department Of Cardiology Shanghai Xuhui Central Hospital

• Wang Wei

  Department Of Biology Graduate School Chinese Academy Of Sciences Beijing

• Wang Wei

  Department Of Biochemistry Hainan Medical College

• Liu Chao

  Department Of Pharmacology Tongji Medical College Huazhong University Of Science And Technology

• WANG Wei

  Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology:Hubei Provincial Key Laboratory for Neural Diseases

• Wang Wei

  Department of Anesthesiology, China-Japan Friendship Hospital, the Chinese Ministry of Health, Beijing, China

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