Antidepressant Effects of a Plant-Derived Flavonoid Baicalein Involving Extracellular Signal-Regulated Kinases Cascade
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概要
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Depression and related mood disorders are among the worlds greatest public health problems. Previous studies have demonstrated that baicalein (Bai), one plant-derived active flavonoid, exhibits neuroprotection against ischemic brain injury and stimulates the levels of phosphorylation of extracellular signal-regulated kinase (pERK) and brain-derived neurotrophic factor (BDNF) expression in vivo. In this study, the antidepressant-like effects of baicalein was investigated using acute and chronic animal models of depression. The results showed that acute application of Bai at doses of 1, 2 and 4 mg/kg by intraperitoneal injection (i.p.) significantly reduced the immobility time in the forced swimming test (FST) and tail suspending test (TST) of mice. In addition, the chronic application of Bai by i.p. for 21 d also reduced the immobility time and improved locomotor activity in chronic unpredictable mild stress (CMS) model rats. Furthermore, it was shown that Bai reversed the reduction of extracellular ERKs phosphorylation and the level of BDNF expression in the hippocampus of CMS model rats. These results suggest that Bai produce an antidepressant-like effect and this effect is at least partly mediated by hippocampal ERK-mediated neurotrophic action.
著者
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Xiong Zhe
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Jiang Bo
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Wu Peng-Fei
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Tian Jia
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Shi Liang-Liang
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Gu Jun
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Hu Zhuang-Li
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Fu Hui
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Wang Fang
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Chen Jian-Guo
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
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Jiang Bo
Department Of Chemistry Xuzhou Normal University Key Laboratory Of Biotechnology For Medicinal Plant
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Xiong Zhe
Department Of Pharmacology Tongji Medical College Huazhong University Of Science And Technology
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Wang Fang
Department Of Electronics Engineering And Institute Of Electronics National Chiao Tung University
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Gu Jun
Department Of Computer Science Science & Technology University Of Hong Kong
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Wang Fang
Department Of Chemistry Box 8204 North Carolina State University
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