Effect of Aging on the Development of Glucose Intolerance Induced by a Low-Carbohydrate Diet in Rats

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概要

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• The effect of aging on the development of glucose intolerance between 2 kinds of diets, a low-carbohydrate/high-fat (LC/HF) diet and a control diet was investigated. A total of 20 eight-week-old S. D. rats were randomly divided into 2 groups of 10 rats each and at 10, 20, 40, 60 and 80 weeks of age, rats were switched to either control or LC/HF diet for 7 days. At 16:00 on the day following the 7th day of feeding, rats underwent an oral glucose tolerance test (OGTT). LC/HF feeding for 7 days impaired the glucose tolerance in rats. Moreover, insulin secretion decreased with age and insulin resistance increased after 60 weeks of age when rats were fed the LC/HF diet, and fasting plasma free fatty acids (FFA) concentrations increased with age. Thus, we speculated that the age-related impairment of insulin action through the glucose fatty-acid cycle might be closely associated with the onset and development of diabetes mellitus.

• 社団法人日本薬学会の論文
• 2003-10-01

著者

• Wang Yuan

  Internal Medicine Fourth Affiliated Hospital Hebei Medical University

• QIN LI-QIANG

  Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow Un

• KANEKO TAKASHI

  Department of Environmental Health, School of Medicine, Yamanashi University

• SATO AKIO

  Department of Environmental Health, School of Medicine, Yamanashi University

• Li Jue

  Department of Environmental Health, School of Medicine, University of Yamanashi

• Wang Jing

  Department of Environmental Health, School of Medicine, University of Yamanashi

• Wang Yuan

  Department of Environmental Health, School of Medicine, University of Yamanashi

• Li Jue

  Department Of Cardiology Tongji Hospital Of Tongji University

• Li Jue

  Department Of Environmental Health School Of Medicine University Of Yamanashi:heart Lung And Blood V

• Qin Li-qiang

  Jiangsu Provincial Key Lab. Of Radiation Medicine And Protection

• Kaneko Takashi

  Department Of Environmental Health School Of Medicine Yamanashi University

• Oya Masakazu

  Department of Environmental Health, Faculty of Medicine, University of Yamanashi

• Oya Masakazu

  Department Of Environmental Health Faculty Of Medicine University Of Yamanashi

• Wang Jing

  College Of Medicine Tongji University

• Sato Akio

  Department Of Environmental Health School Of Medicine Yamanashi University

• Wang Jing

  Heart Lung And Blood Vessel Center College Of Medicine Tongji University

• Wang Jing

  Department Of Echocardiography Union Hospital Tongji Medical College Huazhong University Of Science

• Qin Li-qiang

  Department Of Nutrition And Food Hygiene School Of Radiation Medicine & Public Health Soochow Un

• Wang Yuan

  Department Of Animal Resource & Science Dankook University

• Kaneko Takashi

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Niigata University

• Sato Akio

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• Kaneko Takashi

  Department Of Applied Biological Science Science University Of Tokyo

• Wang Jing

  Department Of Biological Sciences Texas Tech University

• SATO Akio

  Department of Environmental Health, Yamanashi Medical University

• KANEKO Takashi

  Department of Environmental Health, Yamanashi Medical University

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