Soyfood Intake in the Prevention of Breast Cancer Risk in Women : A Meta-Analysis of Observational Epidemiological Studies
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概要
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Many studies have suggested that the intake of soy products may protect against the occurrence of breast cancer because of the considerable amount of isoflavones they contain. To review the results of the observational studies, we performed this meta-analysis of the relevant literature. We searched Medline for reports that examined the association between soyfood consumption (or isoflavone intake) and breast cancer risk from January 1966 to April 2006. The random-effects model was used to estimate the pooled relative risk (RR). Twenty-one independent studies (14 case-control studies and 7 cohort studies) were included in the final analysis. The pooled RR of breast cancer for soyfood intake was 0.75 with a 95% CI of 0.59-0.95. As the main types of soyfood in Japan and China, tofu and miso showed clear protective effects. Isoflavone intake resulted in a 20% decrease in risk (RR=0.81, 95% CI 0.67-0.99). The pooled RR varied little according to study stratification. When the studies published in Japanese and Chinese were added, the inverse associations between soyfood, tofu and breast cancer risk became slightly stronger. The weak association of miso was possibly due to the high concentration of salt in miso soup. In the present analysis, we did not find strong evidence for publication bias in the combination of the studies. This meta-analysis supported the hypotheses that soyfood intake may be associated with a decreased risk of breast cancer due to the isoflavones. Further epidemiological studies need to be conducted with more comprehensive information about the soyfood, and more accurate assessment of the isoflavones.
著者
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HOSHI KAZUHIKO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi
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Wang Pei-yu
Department Of Social Medicine And Health Education School Of Public Health Peking University
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QIN Li-Qiang
School of Radiology and Public Health, Soochow University
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XU Jia-Ying
School of Radiology and Public Health, Soochow University
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Qin Li-qiang
Jiangsu Provincial Key Lab. Of Radiation Medicine And Protection
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Wang P‐y
Department Of Social Medicine And Health Education School Of Public Health Peking University
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Wang Pei-yu
中華人民共和国
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Hoshi Kazuhiko
Department Of Obstetrics And Gynecology School Of Medicine University Of Yamanashi
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Hoshi Kazuhiko
Department Of Obstetrics And Gynecology
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Xu Jia-ying
Department Of Nutrition And Food Hygiene School Of Radiation Medicine And Public Health Soochow Univ
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Wang Pei-yu
Department Of Preventive Medicine And Health Education School Of Public Health Beijing University
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WANG Pei-Yu
Department of Environmental Health, Yamanashi Medical University
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