The Effects of Commercial whole Milk on the Prostate Carcinogenesis in Rats with or without Induction by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
スポンサーリンク
概要
- 論文の詳細を見る
Prostate cancer has become the most common male cancer in Western countries and the incidence of this disease is increasing steadily in developing countries including China. The aim of the present study was to determine whether milk consumption promotes the development of prostate carcinogenesis in rats since milk consumption is considered to be a risk factor in some epidemiological studies. In the present study, we compared the prostate carcinogenesis in rats fed on commercial whole milk and artificial milk with or without induction by amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP). The atrophic changes became more serious in the ventral prostate in the milk groups with or without PhIP administration than in the corresponding artificial milk groups. In the ventral prostate, the incidence of prostatic intraepithelial neoplasia (PIN) also was significantly higher in the milk group than in the artificial milk group irrespective of PhIP administration. The rats given PhIP, either fed on milk or artificial milk, showed significantly higher incidences of PIN and adenocarcinoma in the ventral prostate, and dysplasia in the seminal vesicle. The present study suggests that commercial whole milk is likely to promote the development of prostate, especially ventral prostate, carcinogenesis in rats.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
-
Wang Pei-yu
Department Of Social Medicine And Health Education School Of Public Health Peking University
-
QIN LI-QIANG
Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow Un
-
XU JIA-YING
Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow Un
-
SATO AKIO
Department of Environmental Health, School of Medicine, Yamanashi University
-
Li Jue
Department of Environmental Health, School of Medicine, University of Yamanashi
-
Wang Jing
Heart, Lung and Blood Vessel Center, College of Medicine, Tongji University
-
Li Jue
Department Of Cardiology Tongji Hospital Of Tongji University
-
Li Jue
Department Of Environmental Health School Of Medicine University Of Yamanashi:heart Lung And Blood V
-
Qin Li-qiang
Jiangsu Provincial Key Lab. Of Radiation Medicine And Protection
-
Wang Jing
College Of Medicine Tongji University
-
Sato Akio
Department Of Environmental Health School Of Medicine Yamanashi University
-
Wang P‐y
Department Of Social Medicine And Health Education School Of Public Health Peking University
-
Wang Pei-yu
中華人民共和国
-
Xu Jia-ying
Department Of Nutrition And Food Hygiene School Of Radiation Medicine And Public Health Soochow Univ
-
Wang Pei-yu
Department Of Preventive Medicine And Health Education School Of Public Health Beijing University
-
Wang Jing
Heart Lung And Blood Vessel Center College Of Medicine Tongji University
-
Qin Li-qiang
Department Of Nutrition And Food Hygiene School Of Radiation Medicine & Public Health Soochow Un
-
Sato Akio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
-
SATO Akio
Department of Environmental Health, Yamanashi Medical University
-
WANG Pei-Yu
Department of Environmental Health, Yamanashi Medical University
関連論文
- Soyfood Intake in the Prevention of Breast Cancer Risk in Women : A Meta-Analysis of Observational Epidemiological Studies
- One-Day Dietary Restriction Changes Hepatic Metabolism and Potentiates the Hepatotoxicity of Carbon Tetrachloride and Chloroform in Rats
- The Effects of Commercial whole Milk on the Prostate Carcinogenesis in Rats with or without Induction by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats
- The Effects of Nocturnal Life on the Circadian Patterns of Sex Hormones in Young Healthy Men
- Effect of Repeated Intake of Disaccharides on Glucose Metabolism and Insulin Secretion in Healthy Adults - Comparison between Sucrose and Maltose
- Partition Coefficients for Gasoline Additives and Their Metabolites
- Metabolic Interactions between Organic Solvents - with Highly and Poorly Metabolized Compounds
- Partition Coefficients and Hepatic Metabolism in vitro of 1-and 2-Bromopropanes
- Assessment of the health effects of trichloroethylene
- Benzene-Associated Leukemia and its Risk Assessment
- Effect of Aging on the Development of Glucose Intolerance Induced by a Low-Carbohydrate Diet in Rats
- Prevalence of Peripheral Arterial Disease and Risk Factors for the Low and High Ankle-Brachial Index in Chinese Patients with Type 2 Diabetes
- PE-440 Prevalence of Peripheral Arterial Disease and Risk Factors for Ankle-brachial Index in Chinese Patients with Type 2 Diabetes(Diabetes/Obesity/Metabolic syndrome-5 (H) PE74,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of t
- Promoting Effects of Milk on the Development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced Mammary Tumors in Rats
- PE-281 Ankle Brachial Index as Atherosclerosis Marker in Chinese High Cardiovascular Risk Patients(Peripheral circulation-5 (H) PE47,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-264 Ankle-brachial index as a predictor of All-Cause and Cardiovascular Disease Mortality in Chinese Patients with High Cardiovascular Risk(Peripheral circulation/Vascular disease(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of
- Evaluation of Medical Treatment for Peripheral Arterial Disease in Chinese High-Risk Patients
- Evaluation of the brain uptake properties of [1-^C]labeled hexanoate in anesthetized cats by means of positron emission tomography
- Prevalence and Risk Factors of the Rural Adult People Prehypertension Status in Liaoning Province of China
- PE-516 Investigation on Correlative Risk Factors and Epidemic Characteriazation of Hypertension among Rural Adult Groups in Liaonong Province(Hypertension, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-515 Prevalence and Risk Factors of the Rural Adult People Prehypertension Status in Liaoning Province of China(Hypertension, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-117 The Preventive Effect of Fastigial Nucleus Stimulation on the Oxidative Damage from Myocardial Infarction in Rats(Acute myocardial infarction, basic-3 (IHD) PE20,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanes
- Investigation of Blood Lipid Levels and Statin Interventions in Outpatients With Coronary Heart Disease in China : The China Cholesterol Education Program (CCEP)
- The Predictive Value of Brachial-Ankle Pulse Wave Velocity in Coronary Atherosclerosis and Peripheral Artery Diseases in Urban Chinese Patients
- Sensitivity and Specificity of Ankle-Brachial Index for Detecting Angiographic Stenosis of Peripheral Arteries
- Prevalence, Awareness, Treatment, and Control of Hypertension in Rural Adults from Liaoning Province, Northeast China
- PE-514 Pulse Pressure and Mean Arterial Pressure to Identify Individuals with Stroke among Uncontrolled Hypertensive Subjects of Chinese Rural Areas(Hypertension, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Mechanical Property Reinforcement of Denture Base Resin with Glass Fiber
- The Association between Ankle-Brachial Index and Cardiovascular or All-Cause Mortality in Metabolic Syndrome of Elderly Chinese
- Effect of Statins and Calcium Channel Blockers on All-Cause Mortality and Cardiovascular and Cerebrovascular Disease Mortality in 958 Chinese Hospitalized Patients with Peripheral Arterial Disease after 13 Months of Follow-up
- Risk Factors of Peripheral Arterial Disease and Relationship Between Low Ankle-Brachial Index and Mortality From All-Cause and Cardiovascular Disease in Chinese Patients With Type 2 Diabetes
- Differential Control of Systolic and Diastolic Blood Pressure : Factors Associated With Lack of Blood Pressure Control in Rural Community of Liaoning Province, China
- The Minerals and Heavy Metals in Cow's Milk from China and Japan
- Grafting Organic and Biomolecules on H-Terminated Porous Silicon from a Diazirine
- A Simple Method for Covalent Immobilization of Proteins on Porous Silicon Surfaces
- Excitation of Baroreceptors Depresses A- and C-Components of the Somato-Cardiac Sympathetic Reflex in Anesthetized Rats
- Hand Dermatitis among Factory Workers in Beijing
- Inhibition of 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis by α-Linolenic Acid and Docosahexanoic Acid in Sprague-Dawley Rats
- Biological Monitoring of Exposure to Organic Solvent Vapors II. Simulation Studies using a Physiological Pharmacokinetic Model for m-Xylene
- Biological Monitoring of Exposure to Organic Solvent Vapors I. A Physiological Simulation Model of m-Xylene Pharmacokinetics in Man
- STUDIES ON THE UTILIZATION OF GRAPE PART V. COLOR CHANGE OF CONCORD GRAPE JUICE BY VARIOUS TREATMENTS AND STORAGE
- STUDIES ON THE UTILIZATION OF GRAPE PART IV. PRODUCTION OF GRAPE JUICE FOR DRINK (2)
- STUDIES ON THE UTILIZATION OF GRAPE PART III. INVERSION OF SUCROSE BY GRAPE JUICE
- STUDIES ON THE UTILIZATION OF GRAPE PART II. PRODUCTION OF GRAPE JUICE FOR DRlNK
- STUDIES ON THE UTILIZATION OF GRAPE PART I. COMPOSITION OF GRAPE JUICES
- Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk
- Uterotrophic effects of cow milk in immature ovariectomized Sprague-Dawley rats
- Reflex Modulation of Catecholamine Secretion and Adrenal Sympathetic Nerve Activity by Acupuncture-Like Stimulation in Anesthetized Rat
- Stimulation of saphenous afferent nerve produces vasodilatation of the vasa nervorum via an axon reflex-like mechanism in the sciatic nerve of anesthetized rats
- The nitric oxide synthase inhibitor L-NAME reduces inhibitory components of somato-vesical parasympathetic reflexes in the rat
- Blood flow in the sciatic nerve is regulated by vasoconstrictive and vasodilative nerve fibers originating from the ventral and dorsal roots of the spinal nerves
- Prevalence of Risk Factors for Cardiovascular Disease and Their Associations with Diet and Physical Activity in Suburban Beijing, China
- Two new triterpenoid saponins from rhizome of Anemone raddeana Regel
- Long-lasting facilitation and depression of periurethral skeletal muscle following acupuncture-like stimulation in anesthetized rats
- The influence of afferent inputs from skin and viscera on the activity of the bladder and the skeletal muscle surrounding the urethra in the rat
- Fabrication of 3D Co_3O_4 Homoarchitectures via a Novel Template-assisted Coprecipitation Process
- Two Types of Cytochrome P-450s for Benzene Metabolism and Their Role in Benzene Myelotoxicity (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Zirconocene Coupling Route to 1, 2-Disilacyclobutanes
- SUGARS IN THE ACID HYDROLYZATES OF POLYSACCHARIDES PART IV. ISOLATION OF LAMINARIBIOSE FROM HYDROL
- Somatic regulation of autonomic functions in anesthetized animals : Neural mechanisms of physical therapy including acupuncture
- SUGARS IN THE ACID HYDROLYZATES OF POLYSACCHARIDES PART III. ISOLATION OF KOJIBIOSE (2-0-α-D-GLUCOPYRANOSYL-D-GLUCOSE) AND β, β-TREHALOSE FROM HYDROL
- Mercury Resistance and R Plasmids in E. coli Isolated from an Aquatic Environment
- Impairment of Glucose Tolerance in Normal Adults Following a Lowered Carbohydrate Intake
- Somatocardiovascular reflexes in anesthetized rats with the central nervous system intact or acutely spinalized at the cervical level
- The Nonlinear Magnetic Susceptibility of YIG in the High Frequency Magnetic Field near the Curie Temperature
- Relaxation Time of Spin System in K_2CuF_4 near T_c Determined by Magnetic Susceptibility Measurement in High Frequency magnetic Field
- The inhibitory role of nitric oxide (NO) in the somatocardiac sympathetic C-reflex in anesthetized rats
- ACTH Secretion during Sleep in a Patient with Nelsons Syndrome
- Numerical analysis of three dimensional velocity profile of highly viscous Newtonian fluid in an agitated vessel with paddle impeller.
- Sediment erosion revealed by study of Cs isotopes derived from the Fukushima Dai-ichi nuclear power plant accident