Promoting Effects of Milk on the Development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced Mammary Tumors in Rats
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概要
- 論文の詳細を見る
To assess the effect of milk on the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors, 48 female Sprague-Dawley rats treated with DMBA were divided into 3 groups and given 1 of 3 test solutions for 20 weeks as their drinking liquid: milk, estrone sulfate solution or tap water. The milk group showed a significantly great incidence (75%) in tumor development compared with the water group (38%) and was comparable to the estrone sulfate group (69%). Mean tumor number per rat in the milk group was significantly higher than that in the water group (p=0.009). We classified the mammary tumors into three histological types: intraductal papilloma, fibroadenoma, and adenocarcinoma. Although the percent of intraductal papilloma and fibroadenoma was almost same among the three groups, malignant tumor was found only in the milk and estrone sulfate groups. In conclusion, our results indicate that milk as well as estrone sulfate promotes the development of DMBA-induced mammary tumors in rat and could be associated with the occurrence of adenocarcinoma.
- 日本組織細胞化学会の論文
著者
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Katoh Ryohei
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, Facult
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Wang Pei-yu
Department Of Social Medicine And Health Education School Of Public Health Peking University
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Katoh Ryohei
Department Of Human Pathology Faculty Of Medicine University Of Yamanashi
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Katoh Ryohei
Department Of Human Pathology University Of Yamanashi Interdisciplinary Graduate School Of Medicine
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Ma De-Fu
Department of Social Medicine & Health Education, School of Public Health, Peking University
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Zhou Hong
Department of Social Medicine & Health Education, School of Public Health, Peking University
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Wang Pei-yu
中華人民共和国
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Ma De-fu
Department Of Social Medicine & Health Education School Of Public Health Peking University:depar
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Wang Pei-yu
Department Of Social Medicine & Health Education School Of Public Health Peking University
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Wang Pei-yu
Department Of Preventive Medicine And Health Education School Of Public Health Beijing University
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Zhou Hong
Department Of Child Adolescent And Women's Health School Of Public Health Peking University
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Wang Pei‐yu
Department Of Social Medicine And Health Education School Of Public Health Peking University Key Lab
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Zhou Hong
Department Of Anatomy And Molecular Histology Interdisciplinary Graduate School Of Medicine And Engi
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WANG Pei-Yu
Department of Environmental Health, Yamanashi Medical University
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