Thyroid Transcription Factor-1 (TTF-1) (Recent Progress In Gene Histochemistry)
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概要
- 論文の詳細を見る
Thyroid transcription factor 1 (TTF-1), as noted earlier, is a "thyroid specific" transcription factor that is a homeodomain-containing protein responsible for transcriptional activation of thyroid-specific genes, thyroglobulin (Tg), thyroperoxidase (TPO), and thyrotropin receptor (TSHr) genes, in thyroid follicular cells. Little is known about the histological localization or distribution of TTF-1 protein and mRNA, even though many papers on TTF-1 have been published in the past ten years. Therefore, we decided to examine the expression of TTF-1mRNA in normal and neoplastic thyroid tissues using immunohistochemistry and in situ hybridization as well as molecular techniques such as Northern blot and RT-PCR. In addition, extrathyroidal expression of TTF-1 was also investigated in some organs. In this paper, we reviewed literature and discussed the role of TTF-1 in thyroid hormonogenesis, and presented its precise localization or distribution in normal and neoplastic thyroid tissues. In addition, extrathyroidal expression of TTF-1 is briefly discussed.
- 日本組織細胞化学会の論文
著者
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Katoh Ryohei
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, Facult
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Kawaoi Akira
Department of Pathology, Yamanashi Medical University
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Kawaoi A
Department Of Pathology Yamanashi Medical University
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Kawaoi Akira
山梨医科大学 病理
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Kawaoi A
Yamagata Medical Univ. School Of Medicine Yamagata
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Kawaoi Akira
米国
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Katoh R
Yamanashi Medical Univ.
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Katoh Ryohei
Department Of Pathology Interdisciplinary Graduate School Of Medicine And Engineering University Of
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Katoh Ryohei
Department Of Pathology Faculty Of Medicine University Of Yamanashi
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Katoh Ryohei
Department Of Human Pathology Faculty Of Medicine University Of Yamanashi
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Kawaoi Akira
Department Of Pathology Nihon University School Of Medicine
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MIYAGI Eri
Department of Pathology, Yamanashi Medical University
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Suzuki Koichi
Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and
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SUZUKI Koichi
Second Department of Pathology, Yamanashi Medical College
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Suzuki Koichi
米国
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Suzuki K
Geriatrics Research Institute
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Kawaoi A
Yamanashi Medical Univ. Yamanashi Jpn
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Kawaoi Akira
2nd Department Of Pathology Yamanashi Medical University
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Miyagi Eri
Department Of Pathology Yamanashi Medical University
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Kato Ryohei
Second Department Of Pathology Yamanashi Medical University
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Suzuki Koichi
Cell Regulation Section Metabolic Disease Branch National Institute Of Diabetes And Digestion And Ki
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