The Role of Oxidative Stress on Pathogenesis of Hypertensive Arterial Lesions in Rat Mesenteric Arteries
スポンサーリンク
概要
- 論文の詳細を見る
Examination of the mesenteric arteries of experimental hypertensive rats revealed leukocyte adhesion to the endothelium, leukocyte infiltration, deposition of fibrinoid substance in the intima, and severe medial smooth muscle cell injury. After injecting hypertensive rats with nitro-blue tetrazolium (NBT), formazan deposits which were reaction product that NBT was reduced by superoxide were observed in the endothelial and medial cells of uninjured arteries. Formazan deposition was observed in neutrophils in the lumen of the injured arteries, neutrophils adhering to their endothelium,and neutrophils that had infiltrated in the intima and media. Marked upregulation copper zinc superoxide dismutase (CuZnSOD) and manganese superoxide dismutase (MnSOD) expression was found in the endothelial cells of the arteries of hypertensive rats. Endothelial expression of inducible nitric oxide synthase (iNOS: NOS II) and endothelial nitric oxide synthase (eNOS : NOS III) was strong in the arteries of normotensive rats and decreased in the injured arteries of hypertensive rats, but slight iNOS upregulation was found in the endothelium of uninjured arteries. Deposition of 4-hydroxy-2-nonenal (4-HNE) was observe in the intima of the injured arteries of hypertensive rats. Conclusion : Hypertensive arterial disease is the result of hypertension-in-duced oxidative stress produced by neutrophils, endothelial cells, and medial smooth muscle cells as well as enzyme activity release by neutrophils activated by hypertension.
著者
-
Suzuki Keiji
Division Of Radiation Biology Department Of Radiology And Radiation Biology Graduate School Of Biome
-
MASAWA Nobuhide
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
-
ASAYAMA KOHTARO
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health
-
SAKATA Noriyuki
Department of Pathology, Fukuoka University School of Medicine
-
Sakata N
Department Of Pathology Fukuoka University School Of Medicine
-
Sakata N
Kyushu Univ. Fukuoka Jpn
-
Sakata Noriyuki
Second Department Of Pathology Fukuoka University School Of Medicine
-
Masawa Nobuhide
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
-
TAKATAMA Masamitu
Geriatrics Research Institute
-
Nakazato Kyoumi
Division of Histopathology, Department of Laboratory Sciences, Gunma University School of Health Sci
-
Suzuki K
Geriatrics Research Institute
-
Nakano Katsuya
Department Of Urology Gunma University School Of Medicine
-
Nakazato K
School Of Health Sciences Faculty Of Medicine Gunma University
-
Nakazato Kyoumi
Gunma University School Of Health Sciences
-
Nakazato Kyoumi
Division Of Histopathology Department Of Laboratory Sciences Gunma University School Of Health Scien
-
Masawa N
Department Of Pathology Dokkyo University School Of Medicine
-
Takatama M
Geriatrics Research Institute
-
Asayama Kohtaro
Department Of Pediatrics School Of Medicine University Of Occupational And Environmental Health
-
Asayama K
Department Of Pediatrics School Of Medicine University Of Occupational And Environmental Health
-
Suzuki Keiji
Division Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
-
Suzuki Keiji
Dept. Of Labo. Sciences Gunma Univ. School Of Health Sciences
-
Nakazato Kyomi
Dept. Of Labo. Sciences Gunma Univ. School Of Health Sciences
関連論文
- Castleman's Disease of the Retroperitoneum : With Special Reference to IgG4-Related Disorder
- Cyclin D1 Protein Overexpression in Extramedullary Plasmacytoma : A Clinicopathologic Study of 11 Cases
- "Follicular Variant" of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases
- B-Cell Lymphoma Associated with Sjogren's Syndrome among Japanese Patients : A Clinicopathologic and Immunohistochemical Study of 15 Cases
- Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases
- Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
- Girl with nephrotic syndrome after peripheral blood stem cell transplantation
- Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D
- Usefulness of immunohistochemistry for recognizing metastatic colorectal adenocarcinoma in infarcted lymph nodes
- Hepatic angiomyolipoma resembling an inflammatory pseudotumor of the liver : A case report
- Lymph node lesion in infectious mononucleosis showing geographic necrosis containing cytologically atypically B-cells. A case report
- Threshold values of visceral fat and waist girth in Japanese obese children
- Criteria for medical intervention in obese children : A new definition of 'Obesity disease' in Japanese children
- The Role of Oxidative Stress on Pathogenesis of Hypertensive Arterial Lesions in Rat Mesenteric Arteries
- Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: A clinicopathological and immunohistological study of 21 cases
- Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation
- Two pedigrees of hereditary prostate cancer
- Expression of Thyroid Transcription Factor-1(TTF-1)in Human C Cells and Medullary Thyroid Carcinomas
- EXPRESSION OF THYROID TRANSCRIPTON FACTOR-1(TTF-1)IN HUMAN LUNG TUMOR
- Thyroglobulin : A Master Regulator of Follicular Function via Transcriptional Suppression of Thyroid Specific Genes (Symposium IRegulation of Endocrine Function)
- Thyroid Transcription Factor-1 (TTF-1) (Recent Progress In Gene Histochemistry)
- Differential Image Analysis of Proliferating Cell Nuclear Antigen (PCNA) Expression Level during Experimental Thyroid Carcinogenesis
- Increased Chromosome Instability and Accumulation of DNA Double-strand Breaks in Werner Syndrome Cells
- Biochemical Markers for in Situ Detection of DNA Double Strand Breaks in Cultured Mammalian Cells
- Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages
- Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
- Involvement of Reactive Oxygen Species (ROS) in the Induction of Genetic Instability by Radiation
- Radiation-Induced Chromosome Damage in G_1 Phase Cells as Breaks in Permature Chromosome Condensation (PCC) and Its Biological Meaning
- High prevalence of eosinophilia in growth hormone-deficient children
- Pathologic Evidence of Microvascular Rarefaction in the Brain of Renal Hypertensive Rats
- The pathogenesis of cerebrovascular lesions in hypertensive rats
- Pathology of a dissecting intracranial aneurysm
- JTII-28 CYTOLOGIC FEATURES OF NEUROENDOCRINE TUMORS OF THE LUNG-ESPECIALLY IN LARGE CELL NEUROENDOCRINE CARCINOMA
- Missense Mutation (C1263R) in the Thyroglobulin Gene Causes Congenital Goiter with Mild Hypothyroidism by Impaired Intracellular Transport
- Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer
- Dissecting aneurysms involving both anterior cerebral artery and aorta
- Imprint Cytology of Large B-cell Lymphoma with High Content of Epithelioid Cells : A Report of Two Cases
- Immunohistochemical Localization of Cellular Glutathione Peroxidase in Adult Rat Tissues by Use of Newly Prepared Polyclonal Antibodies
- Immunohistochemical Localization of Copper-Zinc and Manganese Superoxide Dismutases in Human Tissues
- Immunohistochemical localization of superoxide dismutase (SOD) in the background lesions of diisopropanolnitrosamine (DIPN) induced rat thyroid tumor
- The alteration of retinal superoxide dismutase(SOD) in streptozotocin(STZ)-induced diabetic rats : Immunohistochemical study
- IMMUNOHISTOCHEMICAL LOCALIZATION OF COPPER-ZINC AND MANGANESE SUPEROXIDE DISMUTASES IN RAT TISSUES
- Transurethral Balloon Laser Thermotherapy: Effects of a Directionally Shielded Balloon in Canine Prostates
- Formation of advanced glycation end-productmodified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human S
- Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions
- X-Ray Microanalysis at High Accelerating Voltage Detecting Aluminum Accumulation in Mouse Kidney after Short-Term Aluminum Administration
- P4-47 Energy dispersive X-ray microanalysis of Al in mouse kidney after short period oral administration
- Phosphorylated ATM Foci as a Biochemical Marker for DNA Double Strand Breaks
- INTER-LABORATORY VALIDATION STUDY OF THE SKIN^2 DERMAL MODEL ZK1100 AND MTT CYTOTOXICITY ASSAY KITS
- Immunohistochemical Localization and Quantitative Analysis of Superoxide Dismutases in Fetal and Neonatal Rat Tissues : Fluorescence Microscopy Image Analysis
- Learning of Virtual Words Utilized in Negotiation Process between Agents (Special Section of Papers Selected from ITC-CSCC'99)
- Multiple Ant Colonies Algorithm Based on Colony Level Interactions
- Cooperative Search Based on Pheromone Communication for Vehicle Routing Problems(Special Section of Papers Selected from ITC-CSCC'97)
- Familial Prostate Cancer in Four Brothers
- Significance of Measurement of Prostate Specific Antigen (PSA) in Familial Prostate Cancer Lines
- Superoxide Dismutase Is Induced During Rat Pancreatic Acinar Cell Injury
- Immunochemical and Immunohistochemical Studies on Distribution of Elastin Fibres in Human Atherosclerotic Lesions using a Polyclonal Antibody to Elastin-derived Hexapeptide Repeat
- Conformational Analysis and Preparation of Polyclonal Antibody for the Domain 26A of Human Elastin
- Preparation of Polyclonal Antibody Against Elastin Hexapeptide Sequence and Its Recognition Site
- Retarded Fibronexus Formation and Cell Attachment on Type V Collagen
- Morphological Aspects of Superoxide Dismutase-1 Mutation in Amyotrophic Lateral Sclerosis and its Transgenic Mouse Model (Symposium VIIHistochemistry for Neuroscience Research)
- Plasma Levels of Orexin-A and Leptin in Obese Children
- Type V hyperlipoproteinemia in systemic lupus erythematosus
- Clinical Utility of Serum E_2 Assayed by Means of a High-Sensitivity Kit in Children
- Growth Hormone Deficiency and Empty Sella Syndrome Diagnosed Because of Failure to Catchup When on Treatment for Hypothyroidism
- Changes in Serum Leptin Concentration During Behavioral Therapy in Obese Children
- Metabolism of High Density Lipoprotein Cholesterol in Kawasaki Disease: Multiple Regression Analysis
- Changes in Serum High-Density Lipoprotein Subfraction Cholesterol in the First Four Weeks of Life
- Immunohistochemical Demonstration of Metallothionein in the Rat Epididymis and Spermatic Cord(Endocrinology)
- Stimulative Effect of Transforming Growth Factor-β on Collagen Synthesis by Human Prostatic Stromal Cells In Vitro
- Pathogenesis of Lactobacillus Casei Cell Wall Extract-Induced Cardiovasculitis
- Immunohistochemical staining with newly developed metallothionein fragment antibodies against NH_2-terminal, middle-regional and COOH-terminal peptides in rabbits
- Metallothionein and Metallothioneinn mRNA Expression in Mice Treated with Cadmium, Copper, and Mercury
- Metallothionein in the Thyroid Gland
- Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases
- Adhesion Molecule and Cytokines of Hypertensive Rat Arteries
- P4-06 Basigin expression in esophageal carcinoma
- A-26 Basigin expression in esophageal carcinoma
- P-49 Aging Changes and Dysplasia with Aging of the Esophageal Mucosa
- Effects of Advanced Glycation End-products on the Proliferation and Fibronectin Production of Smooth Muscle Cells
- METALLOTHIONEIN IN HUMAN SEMINAL PLASMA
- In vivo Insulin Sensitivity and Insulin Binding to Erythrocytes in Children : Insulin Resistance in Obese Children
- 113 SERUM OF OXIDISED LDL LEVEL IN OBESE CHILDREN
- 135 OREXIN A STIMULATES CATECHOLAMlNE SYNTHESIS THROUGH OREXIN RECEPTOR 1 IN BOVINE ADRENAL MEDULLARY CELLS
- 235 A NOVEL MUTATION (P168L) AT EXON 5 OF PHEX GENE IN A CASE WITH X-LINKED HYPOPHOSPHATEMIC RECKETS
- 61 DECREASED SERUM ADIPONECTIN LEVEL IN OBESE CHILDREN
- 174 STUDY OF CORTISOL SECRETION IN CULTURED ADRENOCORTICAL ADENOMA CELLS FROM A PATIENT WITH CUSHING'S SYNDROME
- Pharmacokinetics and dosing of arbekacin in preterm and term newborn infants
- Metallothionein (MT) 1/2 expression in MT 1/2 and MT 3 knock-out mice and Long-Evans Cinnamon (LEC) rats
- Lymph Node Lesion of Acute Infectious Mononucleosis in the Elderly : A Case Report
- 139 NEONATAL MANIPULATIONS OF OXYTOCIN ALTER OXYTOCIN AND VASOPRESSIN IMMUNOREACTIVE CELLS IN THE PARAVENTRICULAR HYPOTHALAMIC NUCLEUS OF PRAIRIE VOLE IN A GENDER-SPECIIFIC
- Epithelioid Cell Granulomatous Response of Waldeyer's Ring among Japanese : A Clinicopathological and Immunohistochemical Study of 16 Cases
- Presence of Immunoglobulin Heavy Chain Rearrangement in So-Called IgG4-Related Plasma Cell Granuloma of the Eyelid
- Characterisation of Apoptosis in myb-Transformed Hematopoietic Cell (MTHC-A) Lines : TNF-α-Induced Apoptosis and Prevention by cAMP#
- Epithelioid Cell Granulomatous Response of Waldeyer's Ring among Japanese : A Clinicopathological and Immunohistochemical Study of 16 Cases
- Pathogenesis of Focal Cytoplasmic Necrosis of the Smooth Muscle Cells in Hypertensive Rat Arterial Media