Characterisation of Apoptosis in myb-Transformed Hematopoietic Cell (MTHC-A) Lines : TNF-α-Induced Apoptosis and Prevention by cAMP#
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概要
- 論文の詳細を見る
Myb-transformed haematopoietic cell (MTHC) lines have been developed and clones selected based on their ability to respond to tumor necrosis factor (TNF)-α. MTHC-A cells underwent apoptosis in response to TNF-α (MTHC-A). The apoptotic effect of TNF-α in MTHC-A was mimicked by a specific inhibitor of protein kinase A (PKI 5-24) and by the tyrosine kinase inhibitor genistein, suggesting that phosphorylation of tyrosine and PKA activity were important in protecting MTHC from apoptosis. Agents that elevate intracellular levels of cAMP, e.g. cholera toxin and dibuteryl cAMP, protected MTHC-A from the apoptotic effects of TNF-α, and also reduced the apoptotic effects of PKI and genistein. MTHC-A thus provides a useful model for investigating the role of TNF-mediated apoptosis in regulation of the myeloid lineage of cells. [<I>J Clin Exp Hematop 53(2) : 115-120, 2013</I>]
著者
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KANEKO Yuko
Department of Internal Medicine, Keio University School of Medicine
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Masawa Nobuhide
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Fukasawa Ichio
Department Of Obstetrics And Gynecology Dokkyo Medical University School Of Medicine
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Sorimachi Kenji
Department of Obstetrics and Gynecology, Dokkyo Medical University
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Sorimachi Kenji
Department of Chemistry, Faculty of Engineering, Gunma University
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Waring Paul
Faculty of Chemistry, Australian National University
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J Hapel
Department of Haematology, Division of Science and Design, University of Canberra
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Kaneko Yuko
Department of Anatomic Diagnostic Pathology, Dokkyo Medical University
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Kaneko Yuko
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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Masawa Nobuhide
Department of Anatomic Diagnostic Pathology, Dokkyo Medical University
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