Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases
スポンサーリンク
概要
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Atypical lymphoplasmacytic immunoblastic proliferation (ALPIB) is a rare lymphoproliferative disorder (LPD) associated with autoimmune disease (AID). To further clarify the clinicopathologic, immunohistological, and genotypic findings of ALPIB in lymph nodes associated with well-documented AIDs, 9 cases are presented. These 9 patients consisted of 4 patients with systemic lupus erythematosus, 3 patients with rheumatoid arthritis, and one case each with Sjögrens syndrome and dermatomyositis. All 9 patients were females aged from 25 to 71 years with a median age of 49 years. Four cases presented with lymphadenopathy as the initial manifestation. In 4 patients, immunosuppressive drugs were administered before the onset of lymph node lesion. However, none of the 9 patients received methotrexate therapy. The present 9 cases were characterized by : (i) prominent lymphoplasmacytic and B-immunoblastic infiltration ; (ii) absence of pronounced arborizing vascular proliferation ; (iii) absence of CD10+ “clear cells” ; (iv) presence of hyperplastic germinal center in 7 cases ; (v) immunohistochemistry, flow cytometry, and polymerase chain reaction demonstrated a reactive nature of the T- and B-lymphocytes ; and (vi) on in situ hybridization, there were no Epstein-Barr virus -infected lymphoid cells in any of the 9 cases. Overall 5-year survival of our patients was 83%. The combination of clinical, immunophenotypic, and genotypic findings indicated that the present 9 cases can be regarded as having an essentially benign reactive process. Finally, we emphasized that ALPIB should be added to the differential diagnostic problems of atypical LPDs, particularly lymph node lesions of IgG4-related diseases.
- 2010-11-01
著者
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Nakamura Naoya
Department of Pathology, Tokai University School of Medicine
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NAKAMURA Shigeo
Department of Clinical Pathology, Aichi Cancer Center Hospital
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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IGARASHI Tadahiko
Department of Hematological Oncology, Gunma Cancer Center Hospital
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MASAWA Nobuhide
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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Nakamura S
Department Of Pathology Nagoya University School Of Medicine
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Nakamura Shigeo
国立がんセンター中央病院 血液内科
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Nakamura Shigeo
群馬県立がんセンター 病理検査
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Kojima M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Nakagawa Shun-ichi
鈴鹿中央総合病院(厚生連)
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Muta K
Department Of Pathology School Of Medicine Fukuoka University
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Igarashi Tadahiko
Department Of Hematological Oncology Gunma Cancer Center Hospital
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Igarashi Tadahiko
Division Of Hematology And Oncology National Cancer Center Hospital East
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ITOH Hideaki
Department of Surgery, University of Occupational and Environmental Health, School of Medicine
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Kume M
Department Of Hematology Sapporo Hokuyu Hospital
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Kasai Masaharu
東海大学 医学部
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石井 英昭
Department Of Pathplogy And Clinical Laboratories Maebashi Red Cross Hospital
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Nakamura Shigeo
名古屋大学 医学系研究科血液・腫瘍内科学
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Nakamura Shigeo
Department Of Pathology Nagoya University School Of Medicine
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Kasai M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kikuchi M
Murakami Karindoh Hospital
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Kikuchi Masahiro
福岡大学 医学部内科学第一
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Kato M
Department Of Internal Medicine & Molecular Science Nagoya City University Graduate School Of Me
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Nakamura Shigeo
Department Of Pathology Nagoya University Graduate School Of Medicine
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Tsukamoto Norihumi
Department of Medicine and Clinical Science, Gunma University School of Medicine
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Matsuda Hazuki
Department of Anatomic Diagnostic Pathology, Dokkyo University School of Medicine
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Kobayashi Satsuki
Department of Internal Medicine, Toho Hospital
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Ueki Kazue
Department of Internal Medicine, Toho Hospital
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Irisawa Hiroyuki
Division of Hematological Oncology, Gunma Cancer Hospital
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Murayama Kayoko
Division of Hematological Oncology, Gunma Cancer Hospital
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Kume Masaaki
Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine
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Kume Masaaki
Department Of Internal Medicine Iii Akita University School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kikuchi Masahiro
Department Of Internal Medicine National Miyakonojo Hospital
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Kume Masaaki
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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Kami Masahiro
Division Of Hematology/oncology Kameda General Hospital
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Kasai Masanobu
First Department Of Internal Medicine Nagoya University School Of Medicine
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Masawa Nobuhide
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Nakamura Shigeo
Department Of Pathology And Clinical Laboratories Nagoya University Hospital
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Nakamura Naoya
Department Of Otorhinolaryngology Faculty Of Medicine University Of Tokyo
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Nakamura S
Department Of Anatomic And Molecular Pathology Aichi Cancer Center Hospital
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Kami Masahiro
Stem Cell Transplant Unit National Cancer Center Hospital
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Tsukamoto Norihumi
Department Of Medicine And Clinical Science Gunma University School Of Medicine
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Masawa N
Department Of Pathology Dokkyo University School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Itoh Hideaki
Department Of Biochemistry Akita University School Of Medicine
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Murayama Kayoko
Department Of Hematological Oncology Gunma Cancer Center Hospital
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Ueki Kazue
Department Of Internal Medicine Toho Hospital
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Kobayashi Masahide
The Department Of Hematology Hamamatsu West Medical Center
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Matsuda Hazuki
Department Of Anatomic Diagnostic Pathology Dokkyo University School Of Medicine
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Murayama Kayoko
Division Of Hematological Oncology Gunma Cancer Hospital
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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Nakamura Satoko
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Irisawa Hiroyuki
Division Of Hematological Oncology Gunma Cancer Hospital
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Kobayashi Satsuki
Department Of Internal Medicine Toho Hospital
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Nakamura Shigeo
Department Of Cardiovascular Diseases. Kokura National Hospital
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Nakamura Shigeo
Department Of Pathology Nagoya University
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Kojima Masaru
Departments Of Pathology And Clinical Laboratories
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NAKAMURA Shigeo
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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