EBV^+ B-cell Lymphoproliferative Disorder Associated with Subsequent Development of Burkitt Lymphoma in a Patient with Idiopathic CD4^+ T-lymphocytopenia
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概要
- 論文の詳細を見る
We report here a case of idiopathic CD4+ T-lymphocytopenia (ICL) associated with Epstein-Barr virus (EBV)+ lymphoproliferative disorder (LPD) terminating in Burkitt lymphoma (BL). A 33-year-old Japanese male was admitted to the hospital showing severe CD4+ lymphocytopenia and neutropenia that was diagnosed as ICL in 1993. Twenty months after the onset of disease, right cervical lymphadenopathy was detected. Biopsy of the specimen showed reactive lymph node hyperplasia and interfollicular B-cell hyperplasia. Ninety-one months later, polypoid tumors were resected from the bilateral nasal cavities and were diagnosed as BL. Immunohistological studies suggested the reactive nature of the initial lymph node biopsy specimen. Polymerase chain reaction (PCR) analyses of immunoglobulin heavy-chain gene (IgH) demonstrated a polyclonal pattern in the initial lymph node lesion. However, the subsequent BL demonstrated a clonal band in the PCR assay for the IgH gene. As demonstrated in human immunodeficiency virus (HIV)-patients, clonal expansion of EBV infected B-cells in the initial lymph node lesion may progress to BL in this patient. The present case did not associate with severe opportunistic infections during the course of disease. EBV+ BL may be the first manifestation of severe immunodeficiency of the ICL in this patient. [J Clin Exp Hematopathol 48(2) : 55-59, 2008]
- 日本リンパ網内系学会の論文
- 2008-11-01
著者
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Nakamura Naoya
Department of Pathology, Tokai University School of Medicine
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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SAKURAI Shinji
Department of Tumor Pathology, Gunma University Graduate School of Medicine
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Sakurai Shinji
Department Of Tumor Pathology Graduate School Of Medicine Gunma University
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MORITA Yukio
Gunma Prefectural Institute of Public Health and Environmental Sciences
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SUGIHARA Shiro
Department of Pathology, Gunma Health Foundation
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Nakamura Naoya
Department Of Pathology Tokai University School Of Medicine
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SHIMANO Shun-ichi
Department of Internal Medicine, Keiaido Hospital
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Nakamura Naoya
Department Of Otorhinolaryngology Faculty Of Medicine University Of Tokyo
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Morita Yukio
Gunma Prefectural Institute Of Public Health And Environmental Science
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Sugihara Shiro
Department Of Pathology Gunma Cancer Center
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Sakurai Shinji
Department Of Chemistry And Material Engineering Faculty Of Engineering Shinshu University
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Shimano Shun-ichi
Department Of Internal Medicine Keiaido Hospital
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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