Clinical Importance of c-Met Protein Expression in High Grade Astrocytic Tumors
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概要
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各種神経上皮由来脳腫瘍におけるc-Met蛋白の発現状況について免疫組織学的に検討した。c-Met陽性細胞が高倍率顕微鏡視野下で全腫瘍細胞の30%以上を占めた症例はアストロサイト由来腫瘍に限られた。悪性グリオーマにおいてc-Metの発現が患者の予後判定因子になりうるかについてepidermal growth factor receptorの発現やMIB-1 labeling indexとの対比をしながら検討したところ、c-Met陽性症例では有意に生存期間が短く、c-Met免疫組織化学は他の2種の指標よりも有用であった。c-Metは分化度の高いアストロサイト系細胞に発現していたが、同蛋白は悪性グリオーマ組織中の各種サイトカインにより誘導されている可能性がある。
- 日本脳神経外科学会の論文
- 1998-12-15
著者
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YOSHIDA Kazunari
Department of Neurosurgery, Keio University School of Medicine
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KAWASE Takeshi
Department of Neurosurgery, Keio University School of Medicine
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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広瀬 雄一
足利赤十字病院 脳神経外科
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Kawase Takeshi
Department Of Chemistry Graduate School Of Science Osaka University
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SHIMAZAKI Kenji
Departments of Neurosurgery, Kawasaki Municipal Hospital
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HAYASHI Takuro
足利赤十字病院脳神経外科
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SAGOH Masachika
足利赤十字病院脳神経外科
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MURAKAMI Hideki
足利赤十字病院脳神経外科
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Yoshida Kazunari
Department Of Neurosurgery Keio University School Of Medicine
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Kojima Masaru
Department Of Pathology And Clinical Laboratories Ashikaga Red Cross Hospital Ashikaga Tochigi
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Shimazaki Kenji
Department Of Neurosurgery Keio University School Of Medicine Tokyo
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Shimazaki Kenji
Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University:(present A
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Kawase Takeshi
Department Of Neurosurgery Keio University School Of Medicine Tokyo
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Yoshida Kazunari
Department Of Neurosurgery Keio University School Of Medicine Tokyo
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Kawase Takeshi
Department Of Chemistry Faculty Of Science Osaka University
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