B-Cell Lymphoma Associated with Sjogren's Syndrome among Japanese Patients : A Clinicopathologic and Immunohistochemical Study of 15 Cases
スポンサーリンク
概要
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To clarify the clinicopathological findings of B-cell lymphoma associated with Sjögrens syndrome (SJS) among Japanese Patients, 15 individuals with this disease were studied. The patients, 14 females and one male, ranged in age from 41 to 73 years with a median age of 56 years. These lymphomas arose not only in the salivary gland (n=4) but also in other mucosal extranodal sites (n=5). Histologically, six cases were marginal zone B-cell lymphoma (MZBL) of the mucosa-associated lymphoid tissue (MALT) type, three cases were diffuse large B-cell lymphoma (DLBCL) + MALT type lymphoma, two cases were nodal MZBL and one case each was small lymphocytic lymphoma, Burkitts lymphoma, CD10+ DLBCL and DLBCL + nodal MZBL. Using in situ hybridization, numerous Epstein-Barr virus+ tumor cells were detected only in the case of Burkitt lymphoma. There were no human-herpes type 8+ tumor cells in any of the 15 cases. There was no API2-MALT1 fusion transcript in any of the eight cases examined. B-cell lymphoma associated with SJS also frequently affected extranodal organs in patients from Japan as well as from patients in Western countries. The majority of B-cell lymphomas in patients with SJS also appear to be low-grade MZBLs or high-grade lymphomas probably derived from MZBL both in Western countries and in Japan. [J Clin Exp Hematopathol 49(2) : 89-95, 2009]
- 2009-11-01
著者
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SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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INAGAKI Hiroshi
Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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SHIMIZU Ken
Department of Pathology, Saitama Social Insurance Hospital
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MASAWA Nobuhide
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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Kojima M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Muta K
Department Of Pathology School Of Medicine Fukuoka University
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ITOH Hideaki
Department of Surgery, University of Occupational and Environmental Health, School of Medicine
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Kume M
Department Of Hematology Sapporo Hokuyu Hospital
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Kasai Masaharu
東海大学 医学部
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石井 英昭
Department Of Pathplogy And Clinical Laboratories Maebashi Red Cross Hospital
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Kasai M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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ISODA Atsushi
Department of Hematology, National Hospital Organization Nishigunma National Hospital
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Kikuchi M
Murakami Karindoh Hospital
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Kikuchi Masahiro
福岡大学 医学部内科学第一
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Kato M
Department Of Internal Medicine & Molecular Science Nagoya City University Graduate School Of Me
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Isoda Atsushi
Department Of Hematology National Hospital Organization Nishigunma National Hospital
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Isoda Atsushi
Department Of Hematology National Nishigunma Hospital
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SHIMIZU Kazuhiko
Department of Pathplogy and Clinical Laboratories, Ashikaga Red Cross Hospital
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Tsukamoto Norihumi
Department of Medicine and Clinical Science, Gunma University School of Medicine
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Kume Masaaki
Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine
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Kume Masaaki
Department Of Internal Medicine Iii Akita University School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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YOKOHAMA Akihiko
Department of Medicine and Clinical Science, Gunma University School of Medicine
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NISHIKAWA Masahumi
Department of Pathology and Clinical Laboratories, National Tochigi Hospital
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MURAYAMA Kayoko
Department of Hematological oncology, Gunma Cancer Center Hospital
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MIYANAGA Tomomi
Division of Pathology, Gunma University School of Medicine
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YOSHIDA Katsue
Department of Pathology and Clinical Laboratories, Kiryu Welfare General Hospital
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Kikuchi Masahiro
Department Of Internal Medicine National Miyakonojo Hospital
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Kume Masaaki
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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Kami Masahiro
Division Of Hematology/oncology Kameda General Hospital
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Kasai Masanobu
First Department Of Internal Medicine Nagoya University School Of Medicine
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Masawa Nobuhide
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Masawa Nobuhide
First Department Of Pathology Dokkyo University School Of Medicine
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Shimizu Kazuhiko
Department Of Pathology Saitama Social Insurance Hospital
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Shimizu Kazuhiko
Department Of Anatomy And Developmental Biology Graduate School Of Medicine Tokyo Women's Medic
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Suzuki Yoshiyuki
Department Of Hepatology Toranomon Hospital
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Suzuki Yoshiyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Yoshida Katsue
Department Of Pathology And Clinical Laboratories Kiryu Welfare General Hospital
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Kami Masahiro
Stem Cell Transplant Unit National Cancer Center Hospital
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Tsukamoto Norihumi
Department Of Medicine And Clinical Science Gunma University School Of Medicine
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Masawa N
Department Of Pathology Dokkyo University School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Itoh Hideaki
Department Of Biochemistry Akita University School Of Medicine
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Inagaki Hiroshi
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Murayama Kayoko
Department Of Hematological Oncology Gunma Cancer Center Hospital
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Miyanaga Tomomi
Division Of Pathology Gunma University School Of Medicine
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Kobayashi Masahide
The Department Of Hematology Hamamatsu West Medical Center
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Nishikawa Masahumi
Department Of Pathology And Clinical Laboratories National Tochigi Hospital
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Inagaki Hiroshi
Department Of Pathology Nagoya City University Graduate School Of Medicine
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Suzuki Yoshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Inagaki Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Yokohama Akihiko
Department Of Medicine And Clinical Science Gunma University School Of Medicine
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Shimizu Ken
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
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Yokohama Akihiko
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Kojima Masaru
Departments Of Pathology And Clinical Laboratories
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SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University, Graduate School of Medicine
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Inagaki Hiroshi
Department of Cardiology, Soka Municipal Hospital
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