Comparison of the Radiobiological Effect of Carbon Ion Beam Therapy and Conventional Radiation Therapy on Cervical Cancer
スポンサーリンク
概要
- 論文の詳細を見る
Little clinical evidence has been provided to show the minimization of radiation resistance of tumors using high linear energy transfer radiation. We therefore investigated the radiobiological and molecular pathological aspects of carbon beam therapy. A total of 27 patients with squamous cell carcinoma (SCC) of the cervix were treated using a carbon beam and 50 control patients with SCC of the cervix using a photon beam. The expression of Ki-67, p53, and p27 proteins before radiotherapy and 5 and 15 days after therapy initiation were investigated using immunohistochemistry. Similar changes were observed in Ki-67 labeling index (LI) and p53 LI during carbon and photon beam therapies. However, for carbon beam therapy, the mean p27 LI significantly decreased from 25.2% before treatment to 18.6% on the 5th day after treatment initiation, followed by a significant increase to 36.1% on the 15th day. In contrast, for photon beam therapy, the p27 LI consistently decreased from the initial 19.9% to 13.7% on the 15th day. Histological effects were observably stronger under carbon than photon beam therapy, though no statistically significant difference was observed (p=0.07 on the 5th day and p=0.10 on the 15th day). The changes in p27 LI under carbon beam therapy were significantly different from those under photon beam therapy, which suggests important molecular differences in the radio-biological response between therapies. Further investigation is required to elucidate the clinical relevance of these putative changes and optimize the relative biological effectiveness of carbon beam to X-ray.
- 日本放射線影響学会の論文
- 2008-09-16
著者
-
NAKANO Takashi
Department of Physics, Kyoto University
-
OHNO Tatsuya
Department of Radiation Oncology, Gunma University Graduate school of Medicine
-
SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University Graduate school of Medicine
-
Ohno Tatsuya
放射線医学総合研究所重粒子医科学センター病院
-
Ohno Tatsuya
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
-
Nakano T
Centrifuge Project Team Nasda
-
Nakano Takashi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
-
Nakano Takashi
Department Of Anatomy Aichi Medical University
-
OKA Kuniyuki
Department of Medical Examination, Mito Saiseikai General Hospital
-
Suzuki Yoshiyuki
Department Of Hepatology Toranomon Hospital
-
Suzuki Yoshiyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
-
Nonaka Tetsuo
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
-
Nonaka Tetsuo
Department Of Radiology Gunma Cancer Center
-
Ohno Tatsuya
Department Of Radiation Oncology Graduate School Of Medicine Gunma University
-
Suzuki Yoshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
-
Oka Kuniyuki
Department Of Pathology Mito Saiseikai General Hospital
-
Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
関連論文
- Effective Potential in the Strong-Coupling Lattice QCD with Next-to-Next-to-Leading Order Effects(Nuclear Physics)
- CT-based 3D Dose-Volume Parameter of the Rectum and Late Rectal Complication in Patients with Cervical Cancer Treated with High-Dose-Rate Intracavitary Brachytherapy
- Current Advancement in Radiation Therapy for Uterine Cervical Cancer
- Protective Effect of Urinary Trypsin Inhibitor on the Development of Radiation-Induced Lung Fibrosis in Mice
- Efficacy of platinum analogue for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization with epirubicin
- The Efficacy of Interferon-beta Monotherapy for Elderly Patients with Type C Hepatitis of Genotype 2
- Potential of laparoscopy in chronic liver disease with hepatitis B and C viruses
- Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus
- Hepatocarcinogenesis Following HCV RNA Eradication by Interferon in Chronic Hepatitis Patients
- The Efficacy of Short-Term Interferon-Beta Therapy for Type C Cirrhotic Patients with Genotype 2a and Low Virus Load
- Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine
- Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma : a pilot study of patients with hepatitis B virus-related cirrhosis
- Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection
- Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter
- Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C
- Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis
- Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan
- Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001
- Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment
- Factors contributing of ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C
- Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis
- Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection
- Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy
- Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation
- Influence of Histological Subtype on Survival after Combined Therapy of Surgery and Radiation in WHO Grade 3 Glioma
- Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure : Morphologic and morphometric analyses
- Intracavitary Combined with CT-guided Interstitial Brachytherapy for Locally Advanced Uterine Cervical Cancer: Introduction of the Technique and a Case Presentation
- B-Cell Lymphoma Associated with Sjogren's Syndrome among Japanese Patients : A Clinicopathologic and Immunohistochemical Study of 15 Cases
- Radiation-induced ICAM-1 Expression via TGF-β1 Pathway on Human Umbilical Vein Endothelial Cells; Comparison between X-ray and Carbon-ion Beam Irradiation
- LATE RECTAL BLEEDING AND GENITOURINARY MORBIDITY AFTER HIGH DOSE RATE BRACHYTHERAPY COMBINED WITH HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY FOR LOCALIZED PROSTATE CANCER
- Effectiveness of combination therapy of splenectomy and long-term interferon in patients with hepatitis C virus-related cirrhosis and thrombocytopenia
- Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma : differences between young and elderly patients
- Changes in viral loads of lamivudine-resistant mutants during entecavir therapy
- Efficacy and anticarcinogenic activity of interferon for hepatitis C virus-related compensated cirrhosis in patients with genotype 1b low viral load or genotype 2
- Evaluation of long-term biochemical responses to combination therapy of interferon plus ribavirin in those infected with hepatitis C virus genotype 1b and high baseline viral load
- Efficacy of lamivudine therapy in elderly patients with chronic hepatitis B infection
- Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy
- A randomized, double-blind, controlled trial of natural interferon-β therapy for e-antigen-negative chronic hepatitis B patients with abnormal transaminase levels
- Nutritional Status of Lactating Mothers and Their Breast Milk Concentration of Iron, Zinc and Copper in Rural Vietnam
- Phosphorous-31 Magnetic Resonance Spectroscopy of Cervical Cancer Using Transvaginal Surface Coil
- Correlation between the temperature of molten state and the SH intensity of 30BaO・15TiO_2・55GeO_2 crystallized glass
- Comparison of the Radiobiological Effect of Carbon Ion Beam Therapy and Conventional Radiation Therapy on Cervical Cancer
- An improved procedure of electron microscopic in situ hybridization for detecting adenovirus DNA
- High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load
- Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine
- Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus
- Application of Mechanical Restitution : Variation of Inotropic Effects of Vagal Stimulation or Verapamil Administration During Irregular Cardiac Rhythm
- Pneumocystis jiroveci pneumonia as an atypical presentation of X-linked agammaglobulinemia
- Deformation capacity of large diameter high strength bolts with waisted shank subjected to axial tensile force
- Primary Breast Lymphoma Successfully Treated with Combination Therapy Including Local Radiation Therapy: A Report of Two Cases
- The Role of Radiation Therapy for Stage IIIB Non-Small Cell Lung Cancer : Impact of Clinical Nodal Stage on Survival
- Status of Japanese Radiation Oncology
- The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Iliac Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer: A Dosimetric Study
- Plasma Aldosterone Concentrations Are Not Related to the Degree of Angiotensin-Converting Enzyme Inhibition in Essential Hypertensive Patients
- Hepatitis G virus infection after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma
- Nucleotide sequences of hepatitis GB virus C. Identification of highly conserved domains in the 5' noncoding region and detection by polymerase chain reaction
- Clinical features of hepatitis B virus genotype A in Japanese patients
- Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load
- Growth Cone Collapse and Neurite Retractions : An Approach to Examine X-irradiation Affects on Neuron Cells
- Immunological alterations found in mesothelioma patients and supporting experimental evidence
- Randomized contolled clinical trial of lymphoblastoid interferon-α for chronic hepatitis C
- Incidence of the appearance of the red color sign on esophageal varices and its predictive factors : long-term observations of 359 patients with cirrhosis
- Twice-daily administration of interferon-beta for chronic hepatitis C is not superior to a once-daily regimen
- Interferon therapy for flare-up of hepatitis B virus infection after emergence of lamivudine-induced YMDD motif mutant
- Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration
- Distinction between chronic hepatitis and liver cirrhosis in patients with hepatitis C virus infection. Practical discriminant function using common laboratory data
- Increased response rate to interferon therapy after a second course in hepatitis C patients who show relapse after the initial course
- Hepatic vascular side effects of styrene maleic acid neocarzinostatin in the treatment of hepatocellular carcinoma
- Fluctuation patterns of HCV-RNA serum level in patients with chronic hepatitis C
- A Device for Simultaneous Application of Sclerotherapy and Endoscopic Ligation for Management of Esophageal Varices
- Clinical and virological features of chronic hepatitis C carriers with normal alanine aminotransferase levels despite positive serum HCV-RNA after interferon therapy
- Theory of XPS and BIS Spectra in Ce_2O_3 and CeO_2
- Nanotransportation system for cholera toxin in Vibrio cholerae 01
- The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Iliac Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer : A Dosimetric Study
- Ceramide Induces Myogenic Differentiation and Apoptosis in Drosophila Schneider Cells
- Heavy-ion-induced bystander killing of human lung cancer cells : Role of gap junctional intercellular communication
- Direct visualization and quantification of the anticancer agent, cis-diamminedichloro-platinum(II), in human lung cancer cells using in-air microparticle-induced X-ray emission analysis
- Development of calcium releasing activity induced by inositol trisphosphate and cyclic ADP-ribose during in vitro maturation of sea urchin oocytes
- Geographical Variation in Seed Weight of Plantago asiatica L.
- Endobrouchial metastasis of breast cancer 5 years after breast-conserving therapy
- Effectiveness of Carbon-ion Beams for Apoptosis Induction in Rat Primary Immature Hippocampal Neurons
- Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas
- Heavy-Ion Microbeam Irradiation Induces Bystander Killing of Human Cells
- A LET-Dependent Decrease in the Apoptotic Response of Normal Human Fibroblast Cultures to Isosurvival Doses of γ-Rays and Energetic Heavy Ions
- Aggressive clinical course of giant cell tumor arising from thoracic vertebra after a long latent period
- The Daily Course of Transpiration Rate and Stomatal Conductance of Polygonum cuspidatum in Mt. Fuji.
- BACTERIAL DENSITY AND DISTRIBUTIONS OF FLUORIDE AND CALCIUM IN HUMAN DENTAL PLAQUE
- A Multicenter Study on the Prevalence of Psychiatric Disorders among New Referrals for Epilepsy in Japan
- Nuclear Translocation of Gold Labeled-testosterone-bovine Serum Albumin Conjugate through the Nuclear Double Membranes in Rat Spermatids
- Connective tissue configuration in the human liver hilar region with special reference to the liver capsule and vascular sheath
- Exposure of Normal Human Fibroblasts to Heavy-Ion Radiation Promotes Their Morphological Differentiation
- Clinical features of measles in immunocompromised children
- Secondary Malignant Fibrous Histiocytoma Following Radiation Therapy for Carcinoma of the Uterine Cervix: Report of Two Cases
- Intracavitary Combined with CT-guided Interstitial Brachytherapy for Locally Advanced Uterine Cervical Cancer : Introduction of the Technique and a Case Presentation
- Acute disseminated encephalomyelitis in a boy with elevated plasma levels of thrombin-antithrombin III complex
- An anomalous muscle linking superior and inferior rectus muscles in the orbit
- Posterior Aspect of the Orbital Septum Is Reinforced by Ligaments
- Electrostatic Interactions between Surfactants and Water Soluble Dyes at the Air/Water Interface as Studied by Second Harmonic Interferometry
- Quarkyonic Matter in Lattice QCD at Strong Coupling
- Radiation-induced ICAM-1 Expression via TGF-β1 Pathway on Human Umbilical Vein Endothelial Cells ; Comparison between X-ray and Carbon-ion Beam Irradiation