CT-based 3D Dose-Volume Parameter of the Rectum and Late Rectal Complication in Patients with Cervical Cancer Treated with High-Dose-Rate Intracavitary Brachytherapy

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概要

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• This study evaluated the efficacy of computed tomography (CT)-based three-dimensional (3D) dose-volume parameters of the rectum as predictor for late rectal complication (LRC) in cervical cancer patients treated with radiotherapy alone. Eighty-four patients treated with a combination of external radiotherapy and high-dose-rate intracavitary brachytherapy between January 2000 and December 2004 were retrospectively analyzed. Brachytherapy was prescribed with standard 2D planning. Patients underwent pelvic CT at brachytherapy. The external rectal wall was contoured on the CT images, and the minimum doses delivered to 0.1cc, 1cc, and 2cc of the most irradiated rectal volumes were calculated with dose-volume histograms. The International Commission of Radiation Units and Measurements (ICRU) rectal point dose was also calculated by conventional method. Total dose (external radiotherapy plus brachytherapy) to the rectum was transformed to the biologically equivalent dose in 2-Gy fractions with α/β of 3 Gy (D0.1cc, D1cc, D2cc and DICRU). The relationships between these dosimetric parameters and the incidence of LRC were analyzed. The 5-year overall actuarial rate of LRC was 26.4%. The values of D0.1cc, D1cc, and D2cc were significantly higher in patients with LRC than in those without (p < 0.001), but the difference in the values of DICRU was not statistically significant (p = 0.10). The rate of LRC increased significantly with increasing D0.1cc, D1cc, and D2cc (p = 0.001). However, no positive dose-response relationship was observed between DICRU and the rate of LRC (p = 0.42). The present study has suggested that CT-based 3D dose-volume parameters of the rectum may be effective for predicting LRC.

• 2010-03-16

著者

• NAKANO Takashi

  Department of Physics, Kyoto University

• KATO Shingo

  Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences

• TRAN Dang

  Department of Gynecology, Ho Chi Minh City Cancer Hospital

• OHNO Tatsuya

  Gunma University Heavy Ion Medical Center, Gunma University Graduate School of Medicine

• KIYOHARA Hiroki

  Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences

• OHKUBO Yu

  Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences

• KAMADA Tadashi

  Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences

• 鎌田 正

  放射線医学総合研究所重粒子医科学センター病院

• 鎌田 正

  北海道大学医学部放射線科

• 鈴木 和美

  Showa College of Pharmaceutical Sciences

• Ohno Tatsuya

  放射線医学総合研究所重粒子医科学センター病院

• Kanai T

  Department Of Accelerator And Medical Physics National Institute Of Radiological Sciences

• Kanai Tatsuaki

  茨城県立医療大学 放射線技術科学科

• Suzuki Kazutoshi

  放射線医学総合研究所分子イメージング研究センター

• KANAI Tatsuaki

  NIRS

• Suzuki K

  Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.

• Tran Dang

  Department Of Gynecology Ho Chi Minh City Cancer Hospital

• Nakano T

  Centrifuge Project Team Nasda

• Nakano Takashi

  Department Of Anatomy Aichi Medical University

• Nakano Takashi

  Department Of Radiology And Radiation Oncology Gunma University Graduate School Of Medicine

• Suzuki K

  Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear

• Kato Hirotoshi

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Kanai Tatsuaki

  Department Of Accelerator And Medical Physics Research Center For Charged Particle Therapy National

• Kanai Tatsuaki

  Department Of Medical Physics National Institute Of Radiological Sciences

• Kato Shingo

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Ohno Tatsuya

  Gunma University Heavy Ion Medical Center Gunma University Graduate School Of Medicine

• Kato Hirotoshi

  Division Of Radiation Medicine National Institute Of Radiological Sciences

• Kamata Tadashi

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Suzuki Kazutoshi

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Suzuki Kazutoshi

  Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National

• Suzuki K

  Molecular Imaging Center National Institute Of Radiological Sciences

• Ohkubo Yu

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Nonaka Tetsuo

  Department Of Radiation Oncology Gunma University Graduate School Of Medicine

• Nonaka Tetsuo

  Department Of Radiology Gunma Cancer Center

• Ohta Toshie

  Radgenomics Research Group National Institute Of Radiological Sciences

• Kanai Tatsuaki

  Div. Acce. Res. Natl. Inst. Radiol Sci.

• Kamada Tadashi

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Tanaka Naritaka

  Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine

• Ohno Tatsuya

  Department Of Radiation Oncology Graduate School Of Medicine Gunma University

• Kato Shingo

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Kato Hiroyuki

  Department Of Radiation Oncology Gunma University Graduate School Of Medicine

• Kamada Tadashi

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

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