Histological Variety of Localized Lymphoid Hyperplasia of the Large Intestine : Histopathological, Immunohistochemical and Genotypic Findings of 16 Cases
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概要
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Previous reports emphasized that localized lymphoid hyperplasia (LLH) of the large intestine is usually histologically characterized by large lymphoid follicles with striking enlarged germinal centers, and a narrow surrounding mantle zone and marginal zone (MZ). To clarify the histological varieties of LLH of the large intestine, 16 such cases have been studied. The present study demonstrated histological diversity of the LLH of the large intestine including (i) reactive follicular hyperplasia (RFH) (n=8), (ii) RFH with progressive transformation of the germinal center (PTGC) (n=3), (iii) RFH with MZ hyperplasia (n=3) and (iv) RFH with PTGC and MZ hyperplasia (n=2). Overall histomorphological findings of the present series appear quite different from previous descriptions of LLH of the large intestine. The present study showed histological variety of the LLH of the large intestine. Moreover, LLH of the large intestine should be differentiated from extranodal marginal zone B-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma as well as follicular lymphoma. Immunohistological studies demonstrated the reactive nature of all 16 lesions. However, three cases showing RFH demonstrated immunoglobulin heavy chain gene rearrangement by polymerase chain reaction study in 12 cases examined. It remains unclear whether these three cases showing RFH could be a sign of the prelymphomatous stage (incipient follicular lymphoma) or representing merely an exaggeration of normal B-cell clonal response in the germinal centers. [J Clin Exp Hematopathol 49(1) : 15-21, 2009]
- 2009-05-01
著者
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Nakamura Naoya
Department of Pathology, Tokai University School of Medicine
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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MOTOORI Tadashi
Department of Pathology, Kitasato University, Kitasato Institute Medical Center Hospital
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Kojima M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Muta K
Department Of Pathology School Of Medicine Fukuoka University
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ITOH Hideaki
Department of Surgery, University of Occupational and Environmental Health, School of Medicine
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Kume M
Department Of Hematology Sapporo Hokuyu Hospital
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Kasai Masaharu
東海大学 医学部
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石井 英昭
Department Of Pathplogy And Clinical Laboratories Maebashi Red Cross Hospital
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Kasai M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kikuchi M
Murakami Karindoh Hospital
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Kikuchi Masahiro
福岡大学 医学部内科学第一
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Kato M
Department Of Internal Medicine & Molecular Science Nagoya City University Graduate School Of Me
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HOSHI Kazue
Department of Pathology, Kameda General Hospital
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ENOMOTO Yasunari
Department of Diagnostic Pathology, Nara Prefectural Medical School
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JOHSHITA Takashi
Department of Pathology, Toho Hospital
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NAKAMINE Hirokazu
Division of Pathology and Immunology, Kansai University for Health Science
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Hoshi Kazue
Department Of Pathology Kameda General Hospital
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Kume Masaaki
Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine
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Kume Masaaki
Department Of Internal Medicine Iii Akita University School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kikuchi Masahiro
Department Of Internal Medicine National Miyakonojo Hospital
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Kume Masaaki
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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Kami Masahiro
Division Of Hematology/oncology Kameda General Hospital
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Kasai Masanobu
First Department Of Internal Medicine Nagoya University School Of Medicine
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Motoori Tadashi
Department Of Pathology Kitasato University Kitasato Institute Medical Center Hospital
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Motoori Tadashi
Department Of Pathology Kitasato University
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Joshita Takashi
Department Of Pathology Toho Hospital
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Johshita Takashi
Department Of Laboratory Medicine Gunma University School Of Medicine
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Nakamine Hirokazu
Division Of Pathology And Immunology Kansai University For Health Science
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Nakamura Naoya
Department Of Otorhinolaryngology Faculty Of Medicine University Of Tokyo
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Kami Masahiro
Stem Cell Transplant Unit National Cancer Center Hospital
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Johshita Takashi
Department Of Pathology Toho Hospital
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Itoh Hideaki
Department Of Biochemistry Akita University School Of Medicine
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Kobayashi Masahide
The Department Of Hematology Hamamatsu West Medical Center
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Nakamura Naoya
Department Of Hematology Niigata University Graduate School Of Medical And Dental Sciences
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Enomoto Yasunari
Department Of Diagnostic Pathology Nara Prefectural Medical School
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Kojima Masaru
Departments Of Pathology And Clinical Laboratories
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MOTOORI TADASHI
Department of Otolaryngology, Kurume University School of Medicine
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