Vascular Endothelial Growth Factor Expression in the Rat Uterus and Placenta throughout Pregnancy
スポンサーリンク
概要
- 論文の詳細を見る
To elucidate the physiological roles during pregnancy of vascular endothelial growth factor (VEGF), we examined the temporal and spatial expression of VEGF protein and mRNA in the rat uterine and placental tissues throughout pregnancy. The uterine tissue of nonpregnant rats, pregnant rats, and the rat placental tissue were examined by Northern blotting, in situ hybridizatjon and immunohistochemistry. Northern analysis revealed the existence of VEGF mRNA in the uterus and placenta regardless of the stage of estrous cycle or pregnancy. The results of in situ hybridization and histochemistry for nonpregnant rat specimens showed that VEGF mRNA and protein accumulated in myometrial smooth muscle cells, glandular epithelial cells, stromal cells, and endometrial epithelial cells during each stage of the estrous cycle. The level of accumulation increased in all but the myornetrial smooth muscle cells on estrus, and further increased during pregnancy. Furthermore fetal compartments such as trophoblasts, trophoblast giant cells, vitelline epithelial cells, and amnion were labeled more strongly than the maternal compartment. In conclusion, the spatial expression of VEGF was relatively constant in rat maternal uterus during the estrous cycle and during pregnancy; however, there was a temporal change of VEGF expression.
- 日本組織細胞化学会の論文
著者
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HOSHI KAZUHIKO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi
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Watanabe Akio
Department of Biological Production, Faculty of Bioresource Sciences, Akita Prefectural University
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Kawaoi Akira
Department of Pathology, Yamanashi Medical University
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Kawaoi A
Department Of Pathology Yamanashi Medical University
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Kawaoi Akira
山梨医科大学 病理
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Kawaoi A
Yamagata Medical Univ. School Of Medicine Yamagata
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Kawaoi Akira
米国
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Katoh Ryohei
2nd Department Of Pathology Yamanashi Medical University
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Watanabe Akio
2nd Department Of Pathology Yamanashi Medical University
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Kawaoi Akira
Department Of Pathology Nihon University School Of Medicine
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Yasumtizu Takehiko
Department of Obstetrics and Gynecology, Yamanashi Medical University
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Shibuya Masabumi
Institute of Medical Science, Univetsity of Tokyo
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Hoshi Kazuhiko
Department Of Obstetrics And Gynecology
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Yasumizu T
Yamanashi Medical Univ. Yamanashi Jpn
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Kawaoi A
Yamanashi Medical Univ. Yamanashi Jpn
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Kawaoi Akira
2nd Department Of Pathology Yamanashi Medical University
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Yasumizu T
山梨医科大学 産婦人科
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Hoshi Kazuhiko
Univ. Yamanashi
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Shibuya Masabumi
Institute Of Medical Science Univetsity Of Tokyo
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Shibuya Masabumi
Institute Of Medical Science University Of Tokyo
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Watanabe Akio
Department Of Biological Production Faculty Of Bioresource Sciences Akita Prefectural University
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