Evaluation of Medical Treatment for Peripheral Arterial Disease in Chinese High-Risk Patients

スポンサーリンク

概要

• 論文の詳細を見る

• Background Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis and is associated with elevated cardiovascular morbidity and mortality. The aim of the present study was to evaluate the use of antiplatelet agents, statins and angiotensin-converting enzyme inhibitors (ACEI) in Chinese high-risk cardiovascular (CV) patients with PAD, with an emphasis on the need for aggressive medical management of all atherosclerotic manifestations. Methods and Results Medical records from 5,263 Chinese patients at high risk of CV were evaluated for the use of antiplatelet agents, statins and ACEI in patients with and without PAD. PAD was defined as an ankle-brachial index (ABI) <0.9 in either leg. Multivariable logistic regression analyses were performed to compare medication use in the 2 groups. A total of 5,254 patients were analyzed (52.9% male, mean age 67.3 years). The prevalence of PAD in the total patient group was 25.4%; 22.5% of them had PAD only. Overall, 5.7% had PAD only, 19.6% had PAD and coronary heart disease (CHD) or stroke or diabetes, 7.7% had CHD only, 12.6% had stroke only, and 13.6% had diabetes only. The 28.9% subjects having none of PAD, CHD, stroke or diabetes were used as the reference group. Only 65%, 37% and 47% of all patients received antiplatelet agents, statins and ACEI, respectively. Antiplatelets, statins, ACEI and all 3 medications were used less frequently in PAD only patients (58.1%, 35.9, 53.5% and 21.6%) vs CHD only (90.9%, 74.5%, 70.6% and 55.9%, p<0.001). All 3 proven efficacious therapies were prescribed for only 56% of patients with CHD only, 8% with stroke only, 13% with diabetes only and 21% with PAD only. Conclusion PAD is prevalent in Chinese high-risk CV patients, equivalent to CHD, but these patients receive less intensive treatment than those with CHD. Programs to improve CV risk reduction in these high-risk patients are needed.

• 社団法人日本循環器学会の論文
• 2006-12-20

著者

• NAKAYAMA Tomohiro

  Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School o

• 中山 智祥

  Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi

• Nakayama Tomohiro

  Division Of Cardiology Mitsui Memorial Hospital

• Hu Dayi

  中華人民共和国

• Ma Yitong

  Heart Center The First Hospital Xinjiang Medical University

• LI Jue

  Heart-Lung-Blood Vessel Center of Tongji Universty, Institute of Heart-Lung-Blood Vessel Disease of

• HU Dayi

  Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of

• Li Jue

  Department Of Cardiology Tongji Hospital Of Tongji University

• Hu Dayi

  Heart Center People's Hospital Of Peking University People's Republic Of China

• Xu Yuanxi

  Department Of Cardiology Tongji Hospital Of Tongji University

• Hasimu Buaijiaer

  Heart, Lung and Blood Vessel Center, College of Medicine, Tongji University

• Yu Jinming

  Heart, Lung and Blood Vessel Center, College of Medicine, Tongji University

• Li Xiankai

  Heart, Lung and Blood Vessel Center, Tongji University

• Xu Yuanxi

  Heart, Lung and Blood Vessel Center, Tongji University

• Zheng Liqiang

  Heart, Lung and Blood Vessel Center, Tongji University

• Zhao Mingzhong

  Heart, Lung and Blood Vessel Center, Tongji University

• Ma Wenlin

  Heart, Lung and Blood Vessel Center, Tongji University

• Yang Jingang

  Heart Center, Beijing Tongren Hospital, Capital Medical University

• Luo Yingyi

  Heart, Lung and Blood Vessel Center, Tongji University

• Zhang Lihua

  Heart, Lung and Blood Vessel Center, Tongji University

• Zou Lilin

  Heart, Lung and Blood Vessel Center, Tongji University

• Xiao Weilin

  Heart, Lung and Blood Vessel Center, Tongji University

• Han Yalei

  Heart Center, Beijing Tongren Hospital, Capital Medical University

• Luo Yingyi

  Heart Lung And Blood Vessel Centre Tongji University

• Zheng Liqiang

  Shengjing Hospital Of China Medical University

• Nakayama Tomohiro

  Division Of Receptor Biology Advanced Medical Research Center Nihon University School Of Medicine

• Li Jue

  Heart Lung And Blood Vessel Center Of Tongji University

• Yu Jinming

  Heart Lung And Blood Vessel Center Tongji University

• Xu Yuanxi

  Heart Lung And Blood Vessel Center Tongji University

• Zou Lilin

  Heart Lung And Blood Vessel Center Tongji University

• Ma Wenlin

  Department Of Cardiology Tongji Hospital Of Tongji University

• Han Yalei

  Heart Center Beijing Tongren Hospital Capital Medical University

• Li Xiankai

  Heart Lung And Blood Vessel Center Of Tongji University

• Xiao Weilin

  Heart Lung And Blood Vessel Center Tongji University

• Zhao Mingzhong

  Heart Lung And Blood Vessel Center Tongji University

• Nakajima Teruo

  Second Department Of Internal Medicine Nihon University School Of Medicine

• Li Jue

  Heart Lung And Blood Vessel Center Tongji University

• Yu Jinming

  Institute Of Clinical Epidemiology School Of Public Health Fudan University

• Hasimu Buaijiaer

  Heart Center The First Hospital Xinjiang Medical University

• Hasimu Buaijiaer

  Division Of Receptor Biology Advanced Medical Research Center

• Nakayama Tomohiro

  Division Of Molecular Diagnostics Advanced Medical Research Center Nihon University School Of Medici

• Yu Jinming

  Clinical Research Institute School Of Public Health Fudan University

• Hu Dayi

  The College Of Medicine Tongji University

関連論文

• Comparison of Endocardial and Epicardial Lesion Size Following Large-Tip and Extra-Large-Tip Transcatheter Cryoablation
• Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men
• Purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene is associated with cerebral infarction in Japanese subjects
• PJ-003 Mechanism of atrial fibrillation after coronary artery bypasses graft surgery : histologic assessment(Arrhythmia, Diagnosis/Pathophysiology/EPS 3 (A) : PJ1)(Poster Session (Japanese))
• Association of SLC6A9 Gene Variants with Human Essential Hypertension
• PJ-144 Efficacy of Low Level Laser Therapy around the Stellate Ganglion in the Treatment of Sick Sinus Syndrome(PJ024,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circ
• Case-control Study of the Role of the Gitelman's Syndrome Gene in Essential Hypertension
• Haplotype Analysis of the Prostacyclin Synthase Gene and Essential Hypertension
• PJ-084 Prevalence and Clinical Significance of Dobutamine-Induced Left Ventricular Outflow Tract Obstruction in Symptomatic Patients with Non-Obstructive Hypertrophic Cardiomyopathy(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese)
• Recurrence of Atrial Fibrillation After Internal Cardioversion of Persistent Atrial Fibrillation : Prognostic Importance of Electrophysiologic Parameters
• OJ-099 Full-Motion, Three Dimensional Pulmonary Vein Imaging Using Intracardiac Echocardiography After Isolation of Pulmonary Veins by Radiofrequency Ablation(Arrhythmia, Diagnosis/Pathophysiology/EPS 7 (A) : OJ12)(Oral Presentation (Japanese))
• OJ-007 Transcatheter Cryoablation of Ventricular Myocardium in Swine(Arrhythmia, Non-Pharmacological Therapy 1 (A) : OJ1)(Oral Presentation (Japanese))
• OE-260 Beneficial Effects of Estrogen on Coronary Flow Velocity Reserve Are Lost in Elderly Postmenopausal Women(Echo/Doppler 12 (I) : OE32)(Oral Presentation (English))
• OE-040 Pharmacologic Preconditioning of Estrogen on Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease(Exercise Test/Cardiac Rehabilitation 1 (IHD) : OE6)(Oral Presentation (English))
• Abnormal Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Brugada Syndrome
• Haplotype-Based Case-Control Study of the Human CYP4F2 Gene and Essential Hypertension in Japanese Subjects
• A Case of Adrenocorticotropin-independent Bilateral Adrenal Macronodular Hyperplasia (AIMAH) with Primary Hyperparathyroidism (PHPT)
• Prevention of Cardiac Hypertrophy by a Sub-Antihypertensive Dose of the ^α_1-Adrenergic Antagonist Bunazosin in Dahl Salt-Sensitive Rats
• PJ-417 Combined Use of Ensite Non-Contact Mapping System and Template Matching for Radiofrequency Catheter Ablation of Right Ventricular Outflow Tract Tachycardia(PJ070,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),
• PJ-011 The Upper Turnover Site in the Reentry Circuit of Common Atrial Flutter-3 Dimensional Mapping and Entrainment Study(PJ002,Atrial/Supraventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting
• PE-489 Idiopathic Ventricular Fibrillation Presenting with Prominent J Wave(PE082,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• White Coat Hypertension in Centenarians
• Ambulatory Blood Pressure Monitoring in Uygur Centenarians
• IS132 Hypertension in the Longevity and Eldely Subjects of Xinjiang China
• OJ-101 Magnetic Resonance Imaging Detects Chronic Left Atrial Wall Injury Post Ablation of Atrial Fibrillation(OJ17,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
• P Wave Morphology of an Arrhythmogenic Focus in Patients With Atrial Fibrillation Originating From a Pulmonary Vein or the Superior Vena Cava
• PJ-785 Novel Imaging Technique of the Pulmonary Veins, Left atrium and Esophagus for Enhancing Safety of Left Atrial Ablation(Arrhythmia, therapy(17)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-774 Surface and Intracardiac Electrogram Characteristics of Induced Ventricular Tachyarrhythmias before Degenerating into Ventricular Fibrillation in Brugada Syndrome(Arrhythmia, diagnosis / Pathophysiology / EPS(11)(A),Poster Session(Japanese),The 72n
• PJ-023 Endocardial Impedance Mapping during Pulmonary Vein Isolation of Atrial Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(12)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-253 Electroanatomical Mapping of the right ventricle in Patients with the Brugada Syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Endocardial Electrograms From the Right Ventricular Outflow Tract After Induced Ventricular Fibrillation in Patients With Brugada Syndrome
• PJ-420 High Sensitivity C-Reactive Protein : A Novel Predictor for Recurrence of Atrial Fibrillation after Catheter Ablation of Persistent Atrial Fibrillation(Atherosclerosis, clinical-11, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• PJ-347 High Speed Rotational Coronary Venous Angiography Improves Delineation of Coronary Venous Anatomy during Cardiac Resynchronization Therapy(CT/DSA-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-299 Comparison of Intravenous Quinidine and Ibutilide on the Inducibility of Ventricular Fibrillation in Patients with Brugada Syndrome(Arrhythmia, therapy-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-038 Electroanatomical Characteristics of Right and Left Atria in Patients with Paroxymal and Chronic Atrial Fibrillation(Arrhythmia, diagnosis/pathophysiology/EPS-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-606 lartogenic Postatrial Fibrillation Ablation Left Atrial Tachicardia/Fulutter(Arrhythmia, diagnosis/pathophysiology/EPS-13 (A) PJ102,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-459 Catheter Ablation of Permsnent Atrial fibrillaion(Arrhythmia, diagnosis/pathophysiology/EPS-12 (A) PJ77,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Analysis of Heart Rate Variability amongst Non-Dipper Kazakh, Xinjiang, China
• PJ-850 Result Messages from Portable ECG Monitoring Devices for Home Use are Appropriate Enough for Users?(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
• PE-319 The Natural Longevity of the Uygur People in the Western Region of China Has Less Chance to Have Atrial Fibrillation?(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circul
• PE-083 Velocity Vector Imaging Derived Phase Analysis of Circumferential Strain Accurately Identifies Patients with Left Ventricular Dyssynchrony(Echo/Doppler(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
• OE-103 The interaction between atrial natriuretic peptide and heart rate variability in human subjects(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• High Density Oligonucleotide Array Analysis Atrial Natriuretic Peptide Sensitivity and Transcriptional Response in Human Vascular Endothelial Cells
• OE-052 Culprit Plaques with Positive Remodeling are Different from Those with Negative Remodeling : Intravascular Ultrasound Radiofrequency Analysis(Intravascular endoscopy/Intravascular ultrasound-1 (I) OE9,Oral Presentation (English),The 70th Anniversar
• Prevalence of Carotid Artery Stenosis in Patients with Coronary Artery Disease in Japan(Peripheral Circulation/Vascular Disease 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Combination Therapy of Carotid Artery Stenting and Coronary Revascularization
• Initial Results of Ikari Guide Catheter for Transradial Intervention : Single Center Experience
• A Haplotype-Based Case-Control Study Examining Human Extracellular Superoxide Dismutase Gene and Essential Hypertension
• PE-434 Haplotype-based case-control study of the receptor (calcitonin) activity modifying protein (RAMP)1 gene and essential hypertension(Hypertension, clinical(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
• Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach : The Millennium Genome Project for Hypertension
• Haplotype-Based Case-Control Study of the Association between the Guanylate Cyclase Activator 2B (GUCA2B, Uroguanylin) Gene and Essential Hypertension
• Common Single Nucleotide Polymorphisms in Japanese Patients with Essential Hypertension : Aldehyde Dehydrogenase 2 Gene as a Risk Factor Independent of Alcohol Consumption
• Relationship between the Thromboxane A_2 Receptor Gene and Susceptibility to Cerebral Infarction
• Polymorphism of the C-Reactive Protein (CRP) Gene Is Related to Serum CRP Level and Arterial Pulse Wave Velocity in Healthy Elderly Japanese
• The Association Study of Calcitonin-Receptor-Like Receptor (CRLR) Gene in Essential Hypertension (EH)(Hypertension, Clinical 7 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Haplotype-Based Case-Control Study Revealing an Association between the Adrenomedullin Gene and Proteinuria in Subjects with Essential Hypertension
• Variable Number of Tandem Repeat of the 5'-Flanking Region of Type-C Human Natriuretic Peptide Receptor Gene Influences Blood Pressure Levels in Obesity-Associated Hypertension
• A Novel Variable Number of Tandem Repeat Polymorphism of the Renin Gene and Essential Hypertension
• A Novel Missense Mutation of Exon 3 in the Type A Human Natriuretic Peptide Receptor Gene: Possible Association with Essential Hypertension
• Association Study between a Novel Single Nucleotide Polymorphism of the Promoter Region of the Prostacyclin Synthase Gene and Essential Hypertension
• Response to : Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects
• Mid-term Outcome of PTCRA (Percutaneous Transluminal Coronary Rotational Angioplasty) in hemodialysis patients
• First Case Report in Japan of Left Ventricular Pacing via a Coronary Vein in a Patient With a Mechanical Tricuspid Valve
• Three-Dimensional Reconstruction of the Coronary Sinus With Rotational Angiography
• Electrocardiographic and Electrophysiologic Characteristics in Patients With Brugada Type Electrocardiogram and Inducible Ventricular Fibrillation : Single Center Experience
• Electrophysiologic and Anatomical Characteristics of the Right Atrial Posterior Wall in Patients With and Without Atrial Flutter : Analysis by Intracardiac Echocardiography
• Catheter Ablation for Three Focal Atrial Tachycardias in a Patient with Prior Fontan Surgery for Tricuspid Atresia
• Identifying the Origin of Right and Left Ectopic Atrial Beats Triggering Atrial Fibrillation before Atrial Transseptal Procedure
• Inducibility of Atrial Flutter in Patients With Atrioventricular Nodal Reentrant Tachycardia
• PJ-615 Prognostic Value of Induced Ventricular Fibrillation in Patients with Brugada Syndrome : Single Center Experience(Arrhythmia, diagnosis/pathophysiology/EPS-14 (A) PJ103,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
• PJ-604 Highly Sensitive C-reactive Protein Level Predicts Recurrence of Atrial Fibrillation After Internal Cardioversion in Patients with Chronic Atrial Fibrillation(Arrhythmia, diagnosis/pathophysiology/EPS-13 (A) PJ102,Poster Session (Japanese),The 70th
• Atrial Electrophysiological Abnormality in Patients With Brugada Syndrome Assessed by P-Wave Signal-Averaged ECG and Programmed Atrial Stimulation
• Haplotype-Based Case-Control Study of Estrogen Receptor α (ESR1) Gene and Pregnancy-Induced Hypertension
• PE-281 Ankle Brachial Index as Atherosclerosis Marker in Chinese High Cardiovascular Risk Patients(Peripheral circulation-5 (H) PE47,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Association Study Using Single Nucleotide Polymorphisms in the Estrogen Receptor β (ESR2) Gene for Preeclampsia
• Comparison between Essential Hypertension and Pregnancy-induced Hypertension : a Genetic Perspective
• -0631- HETEROGENEOUS RESPONSES TO ACUTE ISCHEMIA OF ENDOCARDIAL AND EPICARDIAL ACTION POTENTIALS IN CANINE HEARTS IN SITU : ROLE OF THE ATP-SENSITIVE K^+ CHANNEL.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Action Potential Alternans in the Right Ventricular Outflow Tract in a Patient With Asymptomatic Brugada Syndrome
• Association Study between the Variants of the Human ANP Gene and Essential Hypertension
• Evaluation of Medical Treatment for Peripheral Arterial Disease in Chinese High-Risk Patients
• PE-360 Heart Rate Variability of Uygur Elderly in Xinjiang Hetian Region(ECG/Body surface potential mapping/Holter-4 (A) PE60,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Statin Therapy Reduce the Incidence of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery (Arrhythmia, Pharmacological Therapy 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Frequency-Dependent Electrophysiological Effects of Flecainide, Nifekalant and d,l-Sotalol on the Human Atrium
• Electrophysiological Effect of Adenosine Triphosphate and Adenosine on Atrial and Ventricular Action Potential Duration in Humans
• IS008 Changes in Steady-state and Nonsteady-state Atrial Action Potentials Induced in a Canine Model of Chronic Atrial Fibrillation
• Radiofrequency Catheter Ablation of Coexistent Atrioventricular Reciprocating Tachycardia and Left Ventricular Tachycardia Originating in the Left Anterior Fascicle
• 0019 THE CHANGE OF DOUBLE POTENTIAL BEFORE AND AFTER ISTHMUS ABLATION RECORDED ALONG EUSTACHIAN VALVE AND RIDGE IN PATIENTS WITH ATRIAL FLUTTER.
• 0514 CATHETER ABLATION OF THE ISTHMUS BETWEEN TRICUSPID ANNULUS AND CORONARY SINUS OSTIUM IN COMMON ATRIAL FLUTTER-COMPARISON BETWEEN ELECTRO-PHYSIOLOGICAL APPROARCH AND ANATO-MICAL APPROARCH-
• Comparison of Lesion Size with Extra-Large Tip and Large Tip Transcatheter Cryoablation(Arrhythmia, Diagnosis/Pathophysiology/EPS 7 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Catheter Ablation for Cardiac Autonomic Nerves for Prevention of Atrial Fibrillation(Arrhythmia, Non-pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Atrial Action Potential and Filtered P-Wave Duration in Patients with Persistent Atrial Fibrillation : Relation with Plasma Brain Natriuretic Peptide Level(Arrhythmia, Diagnosis/Pathophysiology/EPS 3 (A), The 69th Annual Scientific Meeting of the Japanese
• Effects of Intravenous Amiodarone and Ibutilide on the Action Potential Duration and Atrial Conduction Kinetics in Human Atrial Fibrillation(Arrhythmia, Pharmacological Therapy 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Delay in Right Ventricular Activation Contributes to Brugada Syndrome : Electrophysiological and Pathological Study(Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Usefulness of Bipolar and Unipolar Recordings in Coronary Sinus during Atrial Fibrillation to Differentiate Coronary Sinus and Left Atrial Potentials(Arrhythmia, Diagnosis/Pathophysiology/EPS 4 (A), The 69th Annual Scientific Meeting of the Japanese Circu
• Serum Osteoprotegerin Levels Are Associated with the Presence and Severity of Coronary Artery Disease
• The impact of the metallic allergy to the in-stent restenosis
• Serum Concentration of alpha-1 Protelnase Inhibitor and alpha-2 Macroglobulin Correlates with Late Lumen Loss Index Following Coronary Stent Implantation
• Left Atrial Tachycardia After Pulmonary Vein Isolation for Atrial Fibrillation
• A Nitric Oxide Synthesis Inhibitor Prevents the ACTH-Stimulated Production of Aldosterone in Rat Adrenal Gland
• Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk

もっと見る 閉じる

スポンサーリンク