Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men
スポンサーリンク
概要
- 論文の詳細を見る
Background: Atherosclerosis leads to myocardial infarction (MI) and P2RY2 plays an important role in this process. The aim of the present study was to investigate the association between human P2RY2 and MI via a haplotype-based case-control study that additionally analyzed the group by sex. Methods and Results: The 310 MI patients and 254 controls were genotyped for 5 single-nucleotide polymorphisms (SNPs) of the human P2RY2 gene (rs4944831, rs1783596, rs4944832, rs4382936, rs10898909). Data were separately analyzed for the total, male, and female subjects. For men, the GA+AA genotype of rs10898909 was significantly higher in MI patients as compared with controls (P=0.040). Logistic regression analysis found a significant difference for the genotype (P=0.016). As compared with controls, the frequencies of the C-A and T-C-A haplotypes were significantly higher (P=0.016, and P=0.045, respectively) in men, whereas the frequencies of the C-G and T-A-A haplotypes were significantly lower (P=0.023, and P=0.025, respectively) in MI patients. Conclusions: The GA+AA genotype, as well as the C-A and T-C-A haplotypes, of human P2RY2 could be genetic markers for MI in Japanese men. (Circ J 2009; 73: 2322-2329)
- 2009-11-20
著者
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SATO Naoyuki
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School o
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IZUMI Yoichi
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University Sch
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KASAMAKI Yuji
Division of Cardiovascular Medicine, Department of Medicine, Nihon University School of Medicine
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OHTA Masakatsu
Division of Cardiovascular Medicine, Department of Medicine, Nihon University School of Medicine
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SOMA Masayoshi
Division of General Medicine, Department of Medicine, Nihon University School of Medicine
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AOI Noriko
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School o
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OZAWA Yukio
Division of Cardiovascular Medicine, Department of Medicine, Nihon University School of Medicine
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DOBA Nobutaka
Life Planning Center
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HINOHARA Shigeaki
Life Planning Center
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NAKAI Toshiko
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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WANG Zhao
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School o
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NAKAYAMA Tomohiro
Department of Cardiovascular Medicine, the First Affiliated Hospital of Xinjiang Medical University
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MATSUMOTO Koichi
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University Sch
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MA Yi
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School o
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笠巻 祐二
日本大学医学部内科学系循環器内科学分野
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小沢 友紀雄
日本大学医学部内科学系循環器内科学分野
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Kasamaki Yuji
日本大学 医学部総合内科学
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笠巻 祐二
日本大学 医学部 内科学講座 内科二部門
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Matsumoto Koichi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Matsumoto K
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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小沢 友紀雄
日本大 医 内科学 内科二部門
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小沢 友紀雄
日本歯科大学 歯学部 内科学
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Soma Masayoshi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Soma Masayoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Soma Masayoshi
Second Department Of Internal Medicine Nihon University School Of Medicine
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中山 智祥
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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笠巻 祐二
Div. Of Cardiovascular Med. Nihon Univ. Sch. Of Med
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泉 洋一
日本大学 内科2
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小沢 友紀雄
日本大学 医学部 内科学講座 内科二部門
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小沢 友紀雄
日本大学 医学部 内科学 講座 内科2部門
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Ma Yitong
Department Of Medicine Xinjiang Medical University Urumqi Xinjiang People's Republic Of China
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Soma Masayoshi
Division Of General Medicine Department Of Medicine Nihon University School Of Medicine
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Kasamaki Yuji
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Wang Zhao
Division Of Laboratory Medicine Department Of Pathology And Microbiology Nihon University School Of
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Aoi Noriko
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Sano Morihiko
Division Of Molecular Diagnostics Department Of Advanced Medical Science ; Nihon University School O
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Ozawa Y
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Ozawa Yukio
日本大学 医学部循環器内科学
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Sato Naoyuki
Division Of Laboratory Medicine Department Of Pathology And Microbiology Nihon University School Of
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Sato Naoyuki
Division Of Clinical Gene Therapy Graduate School Of Medicine Osaka University
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Izumi Youichi
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Izumi Yoichi
日本大学 医学部病態病理学系臨床検査医学
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Matsumoto Koichi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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IZUMI Yoichi
Div. of Cardiovascular Med. Nihon Univ. Sch. of Med
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KASAMAKI Yuji
Div. of Cardiovascular Med. Nihon Univ. Sch. of Med
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Ohta Masakatsu
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Ohta Masakatsu
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Ohta Masakatsu
Division Of Cardiovascular Medicine Nihon University School Of Medicine
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Nakayama Tomohiro
Division Of Molecular Diagnostics Department Of Medical Research Science Nihon University School Of
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Ozawa Yukio
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Sakuma Masahiko
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Ozawa Yukio
2nd Div. Dept Of Intern. Med. Facul. Of Med. Nihon University
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Nakayama Tomohiro
Division Of Receptor Biology Advanced Medical Research Center Nihon University School Of Medicine
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Nakayama Tomohiro
Department Of Cardiology Nihon University School Of Medicine
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Nakai Toshiko
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Ozawa Yukio
Second Department Of Internal Medicine Nihon University School Of Medicine
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Soma Masayoshi
Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine
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Kasamaki Yuji
Department Of Cardiology Nihon University School Of Medicine
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Nakayama Tomohiro
Second Department Of Internal Medicine Nihon University School Of Medicine
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Nakajima Teruo
Second Department Of Internal Medicine Nihon University School Of Medicine
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小沢 友紀雄
日本大学医学部板橋病院第二内科
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Matsumoto Koichi
Division Of Nephrology And Endocrinology Department Of Medicine Nihon University School Of Medicine
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笠巻 祐二
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kunimoto Masako
Division Of Nephrology Hypertension And Endocrinology Department Of Internal Medicine Nihon Universi
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Soma Masayoshi
Division Of General Medicine Department Of Internal Medicine Nihon University School Of Medicine
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Nakayama Tomohiro
Division Of Molecular Diagnostics Advanced Medical Research Center Nihon University School Of Medici
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Sato Mikano
Division Of General Medicine Department Of Internal Medicine Nihon University School Of Medicine
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Kunimoto Masako
Division Of Nephrology Hypertension And Endocrinology Department Of Internal Medicine Nihon Universi
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Sato Naoyuki
Division Of Genomic Epidemiology And Clinical Trials Advanced Medical Research Center Nihon Universi
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Sonoda Masahiro
Second Department Of Cardiology National Hospital Organization Kagoshima Medical Center
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Kunimoto Masako
Division Of Nephrology Hypertension And Endocrinology Department Of Internal Medicine Nihon University School Of Medicine
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Ozawa Yukio
2nd Dept. Of Internal Medicine Nihon University School Of Medicine
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Nakajima Teruo
Division Of Molecular Diagnostics Advanced Medical Research Center Nihon University School Of Medicine
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