Electrophysiological Effect of Adenosine Triphosphate and Adenosine on Atrial and Ventricular Action Potential Duration in Humans
スポンサーリンク
概要
- 論文の詳細を見る
Bolus injection of adenosine triphosphate (ATP) or adenosine is widely used clinically for terminating supraventricular tachycardia. However, bolus injection of these drugs has been reported to provoke atrial fibrillation (Afib). The effects of ATP and adenosine on the monophasic action potential duration (MAPD) of atrial and ventricular muscle was investigated, as well as the changes in the spatial distribution of atrial functional refractoriness caused by adenosine. Bolus injection of ATP and adenosine shortened atrial MAPD; no change was observed in the ventricle. Because local f-f intervals during atrial fibrillation correlate with the atrial refractory period, changes in mean f-f intervals in the right atrial appendge, His bundle region, coronary sinus ostium and distal coronary sinus were compared before and after injection of adenosine during induced Afib. Maximal shortening of f-f intervals was observed in the right atrial appendage. Inhomogeneous shortening of atrial refractoriness may account for the Afib following bolus injection of ATP or adenosine.
- 社団法人日本循環器学会の論文
- 2000-05-20
著者
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Kanmatsuse Katsuo
The second department of internal medicine, Nihon University School of Medicine
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中山 智祥
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Saito Satoshi
The Second Deparyment of Internal Medicine Nihon University School of medicine
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Ozawa Yukio
The Second Deparyment of Internal Medicine Nihon University School of medicine
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Nakai Toshiko
The Second Dpartment of Medicine, Nihon University School of Medicine
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Kojima Toshiaki
The Second Department of Medicine, Nihon University School of Medicine
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Tokai Koichiro
Department Of Cardiology Nihon University School Of Medicine
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Tokai Kohtaroh
Department Of Cardiology Nihon University School Of Medicine
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Kondo Kazuhiko
the Second Department of Medicine, Nihon University School of Medicine
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Kumimoto Satoshi
Department Of Cardiology Nihon University School Of Medicine
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Kunimoto Satoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kondo Kazuhiko
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Kojima Toshiaki
Department Of Cardiology Nihon University School Of Medicine
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Kunimoto Satoshi
National Cardiovascular Center
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Kunimoto Satoshi
The Second Department of Internal Medicine, Nihon University, School of Medicine
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Ozawa Yukio
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Ichio
The Second Department of Internal Medicine, Nihon University School of Medicine
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Ozawa Yukio
2nd Div. Dept Of Intern. Med. Facul. Of Med. Nihon University
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Nakayama Tomohiro
Division Of Receptor Biology Advanced Medical Research Center Nihon University School Of Medicine
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Nakai Toshiko
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Tokai Kotaro
Department Of Cardiology Nihon University School Of Medicine
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Kamata Tomohiko
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Nakajima Teruo
Second Department Of Internal Medicine Nihon University School Of Medicine
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Saito Satoshi
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Tokai Kohtaro
Department Of Cardiology Nihon University School Of Medicine
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Kojima Toshiaki
The Second Department of Internal Medicine, Nihon University School of Medicine
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KUNIMOTO Satoshi
The Second Department of Internal Medicine, Nihon University School of Medicine
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