Frequency-Dependent Electrophysiological Effects of Flecainide, Nifekalant and d,l-Sotalol on the Human Atrium
スポンサーリンク
概要
- 論文の詳細を見る
To compare the effects of class Ic and III antiarrhythmic agents on the termination and prevention of atrial fibrillation, the present study investigated the use-dependent electrophysiological effects of flecainide, nifekalant and d,l-sotalol on the human atrium. Flecainide significantly prolonged effective refractory period(ERP), intra-atrial conduction time (IACT) and monophasic action potential duration(MAPD), and its effects on ERP and IACT were use-dependent. Nifekalalant significantly prolonged ERP and MAPD, and these effects were reverse use-dependent; however, there was no significant change in IACT. d,l-Sotalol significantly prolonged MAPD and the effect was reverse use-dependent. It significantly prolonged ERP, but the effect was not reverse use-dependent. d,l-Sotalol increased IACT in a use-dependent manner. Thus, for atrial fibrillation, class Ic antiarrhythmic agents might be more effective in termination and class III antiarrhythmic agents might be more effective in prevention.
- 社団法人日本循環器学会の論文
- 2000-12-20
著者
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中山 智祥
Department Of Cardiovascular Renal And Endocrine Medicines Research Center And Cardiovascular Functi
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Saito Satoshi
The Second Deparyment of Internal Medicine Nihon University School of medicine
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Ozawa Yukio
The Second Deparyment of Internal Medicine Nihon University School of medicine
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Masaki Riko
Division of Cardiovascular Disease, Department of Medicine, Nihon University School of Medicine
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Watanabe Ichiro
The second Department of Medicine, Nihon University Shool of Medicine
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Nakai Toshiko
The Second Dpartment of Medicine, Nihon University School of Medicine
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Masaki Riko
The Second Department of Medicine, Nihon University School of Medicine
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Kojima Toshiaki
The Second Department of Medicine, Nihon University School of Medicine
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Oshikawa Naohiro
The Second Department of Medicine, Nihon University School of Medicine
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Tokai Koichiro
Department Of Cardiology Nihon University School Of Medicine
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Tokai Kohtaroh
Department Of Cardiology Nihon University School Of Medicine
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Kumimoto Satoshi
Department Of Cardiology Nihon University School Of Medicine
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Kunimoto Satoshi
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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Kojima Toshiaki
Department Of Cardiology Nihon University School Of Medicine
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Kunimoto Satoshi
National Cardiovascular Center
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Kunimoto Satoshi
The Second Department of Internal Medicine, Nihon University, School of Medicine
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Masaki Riko
Division Of Cardiovascular Disease Department Of Medicine Nihon University School Of Medicine
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Ozawa Yukio
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Watanabe Hiromi
The Second Department of Medicine, Nihon University School of Medicine
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Kanmatuse Katsuo
The Second Department of Medicine, Nihon University School of Medicine
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Watanabe Hiromi
The Second Department Of Medicine Nihon University School Of Medicine
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Ozawa Yukio
2nd Div. Dept Of Intern. Med. Facul. Of Med. Nihon University
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Nakayama Tomohiro
Division Of Receptor Biology Advanced Medical Research Center Nihon University School Of Medicine
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Nakai Toshiko
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Tokai Kotaro
Department Of Cardiology Nihon University School Of Medicine
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Kamata Tomohiko
The 2nd Department Of Internal Medicine Nihon University School Of Medicine
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Nakajima Teruo
Second Department Of Internal Medicine Nihon University School Of Medicine
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Oshikawa Naohiro
The Second Department Of Medicine Nihon University School Of Medicine
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Saito Satoshi
The Second Department Of Internal Medicine Nihon University School Of Medicine
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Tokai Kohtaro
Department Of Cardiology Nihon University School Of Medicine
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Masaki Riko
The Second Department of Internal Medicine, Nihon University School of Medicine
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Kojima Toshiaki
The Second Department of Internal Medicine, Nihon University School of Medicine
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Oshikawa Naohiro
The Second Department of Internal Medicine, Nihon University School of Medicine
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KUNIMOTO Satoshi
The Second Department of Internal Medicine, Nihon University School of Medicine
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