ESTIMATION OF PLACENTAL LEUCINE IN ABNORMAL PREGNANCY AMINOPEPTIDASE SERA
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概要
- 論文の詳細を見る
妊婦血清中に新たに増加してくる妊娠特異性leucine aminopeptidase(以下LAPと略す)は,正常血清中のLAPとは異なり,0・02M L-methionine非感受性であり胎盤syncytial cel lysosome由来である。従って,この性質を利用すれば妊婦血清中のplacental LAP(以下P-LAPと略す)のみ選択的測定が可能となる。今回我々は本法を産科臨床に応用し,その診断的価値について検討した.P・LAP活性の測定はO・02ML methionine存在下で竹中法により行った。(1)双胎,正常妊娠に比して高値を示した。(2)切迫流産,予後不良で流産した6例中4例では活性値の下降後に出血,流産が起った。残り2例は活性値の上昇を認めたにもかかわらず流産したが,そのうちの1例は臍帯の卵膜付着例であり胎盤には異常は認められなかった.予後良好で正常分娩に至った6例全例にP-LAP値の下降後に出血が認められた.長期測定が出来たそのうちの2例では,出血が消失し次第に臨床症状が改善するとともに活性値が上昇していくことが観察された.[○!3]妊娠中毒症,継承5例のうち3例は正常妊娠と比し明らかに低値を示した.重症5例では全例活性値の急激な下降とともに子宮内胎児死亡に至った.[○!4]胞状奇胎では妊娠15週以前では,正常妊娠と比して有意の差は認められなかったが,妊娠16週以降では明らかに低値を示した.[○!5]絨毛性腫瘍では非妊時に近い低値であった.本法は連続測定を行った場合に胎盤機能を良く反映し,簡単,迅速鋭敏なため日常の臨床検査に好適である.
- 社団法人日本産科婦人科学会の論文
- 1979-04-01
著者
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MIZUTANI Shigehiko
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine
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Oya Masakazu
Department of Environmental Health, Faculty of Medicine, University of Yamanashi
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Oya Masakazu
Department Of Environmental Health Faculty Of Medicine University Of Yamanashi
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Oya Masakazu
Department Oflegalmedicine Nagoya University School Ofmedicine Nagoya
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Mizutanl Shigehiko
Department Of Obstetrics And Gynecology. Rinko Hospital. Nagoya
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NOTO Hiroshi
Department of Diabetes and Metabolism, Tokyo University Hospital
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Noto Hiroshi
Department Of Obstetrics And Gynecology Hamamatsu University School Of Medicine. Hamamatsu
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Noto Hiroshi
Department Of Diabetes And Metabolism Tokyo University Hospital
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Mizutani Shigehiko
Department Of Obstetrics And Gynaecology Nagoya University Graduate School Of Medicine
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SAKURA Harutake
Department of Obstetrics and Gynecology. Hamamatsu Medical Center. Hamamatsu
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INAMOTO Yutaka
Department of Obstetrics and Gynecology Hamamatsu University School of Medicine. Hamamatsu
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KAWASHIMA Yoshiro
Department of Obstetrics and Gynecology Hamamatsu University School of Medicine. Hamamatsu
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YOSHlNO Masataka
Department of Biochemehtry, Yokohama City University School ofMedicine. Yokohama
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Kawashima Yoshiro
Department Of Obstetrics And Gynecology Hamamatsu Universily School Of Medicine
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Sakura Harutake
Department Of Obstetrics And Gynecology Hamamatsu Medical Center
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Yoshlno Masataka
Department Of Biochemehtry Yokohama City University School Ofmedicine. Yokohama
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Noto Hiroshi
Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine
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