CHANGES IN PLASMA RENIN ACTIVITY (PRA), ANGIOTENSIN I AND PLACENTAL LEUCINE AMINOPEPTIDASE (P-LAP) ACTIVITY DURING NORMAL PREGNANCY
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概要
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正常妊婦血中のレニン活性,アンジオテンシンIの増加率(正常非妊時を100%とする)および胎盤性Leucine Aminopeptidase(P-LAP)活性の動態を検討した.レニン活性およびアンジオテンシンIの増加率はラジオイムノアッセイにより,P-LAP活性はメチオニン非感受性LAPとして著者らの方法により行った.正常妊娠時にはレニン活性およびアンジオテンシンIは非妊時に比し上昇し,両者は妊婦の進行とともにその前期では上昇し,妊娠25〜28週の中期で下降,妊娠後期で再び上昇した.一方,正常妊婦血中のP-LAP活性は妊娠の進行とともに増加し,妊娠38週にはその最高値を示した.12例の正常妊婦につきアンジオテンシンIとP-LAP活性の動態を連続測定により検討したところ,上記と同様の両者の変動が観察された.正常妊娠時におけるレニン活性およびアンジオテンシンIの動態をアンジオテンシン分解酵素としてのP-LAP活性の変動との関連のもとに考察を加えた.
- 社団法人日本産科婦人科学会の論文
- 1983-04-01
著者
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Kobayashi Hiroshi
Department Of Cardiology Tokyo Medical University
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Mizutani Shigehiko
Department Of Obstetrics And Gynaecology Nagoya University Graduate School Of Medicine
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Sakura Harutake
Department Of Obstetrics And Gynecology Hamamatsu Medical Center
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Mizutanl Shigehiko
Department Of Obstetrics And Gynecology Rinko Hospital
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AKIYAMA Haruyuki
Department of Obstetrics aud Gynecology, Nagoya University School of Medicine
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Akiyama Haruyuki
Department Of Obstetrics Aud Gynecology Nagoya University School Of Medicine
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Kobayashi Hiroshi
Department Of Applied Physics School Of Science And Engineering Waseda University
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Kobayashi Hiroshi
Department Of Obstetrics And Gynecology Hamamatsu Medical Center
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