EFFECTS OF PREGNANCY, DELIVERY AND LACTATION IN HYPERPROLACTINEMIA WITH PROLACTIN PRODUCING PITUITARY ADENOMA
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概要
- 論文の詳細を見る
高プロラクチン (PRL) 血症患者が, 妊娠・分娩を経過することにより改善傾向を示すという可能性が報告されている。私どもも高PRL血症患者の血清PRL値の変動から, 妊娠・分娩・授乳が下垂体PRL産生腫瘍に及ぼす影響を検討したので報告する。37例の血清PRL値30 ng/ml以上の高PRL血症を示す挙児希望婦人に, 手術単独, bromocriptine (Br) 内服単独, および手術後Br内服を施行し, 手術単独療法にて妊娠前血清PRL値が正常化した4例と残りの33例 (2回目の妊娠・分娩に至った8例を含む) の2群にわけて検討を加えた。妊娠前血清PRL値が30 ng/ml以上の33例のうち, 妊娠・分娩・授乳により血清PRL値が30 ng/ml以下の正常域となったものは2例のみであった。しかし, 全体として1回目分娩後33例中28例に, また2回目分娩に至った8例中5例に血清PRL値の低下を認めた。さらに妊娠前血清PRL値を, A群: PRL≦100 B群: 100<PRL≦200 C群: 200<PRLという3群に分類した場合, 妊娠前血清PRL値が高いほど, その減少は大であった。また妊娠前血清PRL値に対する, 分娩後の血清PRL値を百分率で表すと, A群: 91.4±22.1% B群: 81.5±7.0% C群: 65.0±6.5% (Mean±SE) となった。また, 手術単独療法にて血清PRL値が正常化した4例では, 妊娠経過中, 血清PRL値に大きな変動はなく, 分娩・授乳終了後に高PRL血症の再発も認めなかった。
- 社団法人日本産科婦人科学会の論文
- 1989-05-01
著者
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近藤 育代
名古屋大
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MIZUTANI Shigehiko
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine
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Tomoda Yutaka
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Tomoda Yutaka
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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SUGANUMA NOBUHIKO
Department of Obstetrics and Gynecology, Nagoya University School of Medicine
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MATSUZAWA Katsuji
Department of Obstetrics and Gynecology, Anjo Kosei Hospital
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MASAHASHI Tetsuo
Department of Obstetrics and Gynecology, Nagoya University, Branch Hospital, Nagoya
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NARITA Osamu
Department of Obstetrics and Gynecology, Nagoya University, School of Medecine, Nagoya
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Mizutani Shigehiko
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Matsuzawa Katsuji
Department Of Obstetrics And Gynecology Anjo Kosei Hospital
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Matsuzawa Katsuji
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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近藤 育代
Department of Obstetrics and Gynecology, Nagoya University School of Medicine
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KIMURA Toshio
Department of Obstetrics and Gynecology, Nagoya University School of Medicine
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OSAWA Masami
Department of Obstetrics and Gynecology, Nagoya University School of Medicine
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Mizutani Shigehiko
Department Of Obstetrics And Gynaecology Nagoya University Graduate School Of Medicine
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Osawa Masami
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Osawa Masami
Department Of Anesthesia Kyoto University Hospital
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Narita Osamu
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Masahashi Tetsuo
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Suganuma Nobuhiko
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Kimura Toshio
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Kimura Toshio
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Narita Osamu
Department Of Obstetrics And Gynaecology Nagoya University School Of Medicine
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MASAHASHI Tetsuo
Department of Obstetrics and Gynecology, Nagoya University School of Medicine
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Suganuma Nobuhiko
Department of Human Health Science, Graduate School of Medicine, Kyoto University
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