FREQUENCY OF CHROMOSOMALLY UNBALANCED GAMETES IN MALE AND FEMALE HAMSTERS HETEROZYGOUS FOR RECIPROCAL TRANSLOCATION
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概要
- 論文の詳細を見る
先天異常児とその家族の染色体調査によると,父親より母親が転座保因者である場合の方が多い.その原因として,1)不均衡配偶子の形成率が男女で異なることや,2)染色体異常配偶子の選択的淘汰が考えられている.ここでは,1)について,相互転座を有するチャイニーズハムスター[T(2;10)3Idr,T(1;2)9Idr]を用いて調査した.相互転座に由来する4価染色体の分離様式別頻度は,第二成熟分裂中期の染色体調査により求めた.その結果,T(2;10)31dr転座ヘテロ雌と雄における,a)交互分離,b)隣接1型分離c)隣接2型分離,d)3:1分離の頻度は,それぞれa)46.3%と46.0%,b)33.4%と32.8%,c)14.4%と15.1%,d)5.9%と6.1%であり,有意な差は認めなかった.また,T(1;2)9Idrでも同様の結果が得られた.一方,転座へテロ雌雄と正常雌雄との交配による胎生4日胚の染色体構成を調べると,染色体不均衡の胚は,いずれも転座へテロ雌の交配群の方が転座ヘテロ雄の交配群より多いという結果を得た.以上のことから,成熟分裂における不均衡な配偶子形成率に雌雄差がないとすれば,染色体異常を有する精子が受精に至るまでに選択的淘汰を受ける可能性が残る.
- 社団法人日本産科婦人科学会の論文
- 1987-04-01
著者
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SONTA Shin-ichi
Department of Genetics, Institute for Developmental Research
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Sonta S
Aichi Prefectural Colony Aichi Jpn
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Sonta Shin-ichi
Dept. Genet. Inst. Develop. Res. Aichi Hum. Serv. Ctr.
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Sonta S
Aichi Prefectural Colony For The Mentally And Physically Handicapped Kasugai Jpn
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Sonta Shin-ichi
Institute For Developmental Research Aichi Prefectural Colony
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Tomoda Yutaka
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine
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Tomoda Yutaka
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Tomoda Yutaka
Department Of Obstetrics And Gynecology. School Of Medicine Nagoya University
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可世木 博
Department of Obstetrics and Gynecology. School of Medicine, Nagoya University
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可世木 博
可世木病院
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Sonta Shin-ichi
Department Of Genetics Institute For Developmental Research
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