Mitomycin C-induced meiotic crossing-over on the interstitial segments in the Chinese hamster heterozygous for a reciprocal translocation.
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概要
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Using Chinese hamsters heterozygous for T(2;10)3Idr and T(1;3)8Idr reciprocal translocations, the authors studied mitomycin C(MMC)-induced crossing-over on the interstitial segments. Marker chromosomes with unequal-length chromatids resulting from crossing-over were clearly detectable, and the frequencies of such marker chromosomes were constant among individual males which were heterozygous for the same reciprocal translocation. The frequency of MMC-induced crossing-over on the interstitial segments increased roughly with increase in dose. These findings, therefore, indicated that marker chromosomes with unequal- length chromatids in translocation heterozygotes may be a useful indicator for detection of the cytogenetic effects of environmental mutagens on germ cells.
- 日本遺伝学会の論文
著者
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Sonta Shin-ichi
Department Of Genetics Institute For Developmental Research
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SONTA Shin-ichi
Department of Genetics, Institute for Developmental Research, Aichi Prefectural Colony for the Mentally and Physically Handicapped
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KONGI Zhei
Department of Genetics, Institute for Developmental Research, Aichi Prefectural Colony for the Mentally and Physically Handicapped
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